![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MARC1 |
Gene summary for MARC1 |
![]() |
Gene information | Species | Human | Gene symbol | MARC1 | Gene ID | 64757 |
Gene name | mitochondrial amidoxime reducing component 1 | |
Gene Alias | MARC1 | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q5VT66 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64757 | MARC1 | LZE2T | Human | Esophagus | ESCC | 9.54e-06 | 5.03e-01 | 0.082 |
64757 | MARC1 | LZE22T | Human | Esophagus | ESCC | 1.57e-03 | 2.11e-01 | 0.068 |
64757 | MARC1 | P1T-E | Human | Esophagus | ESCC | 2.97e-02 | 1.54e-01 | 0.0875 |
64757 | MARC1 | P2T-E | Human | Esophagus | ESCC | 7.31e-14 | 2.49e-01 | 0.1177 |
64757 | MARC1 | P4T-E | Human | Esophagus | ESCC | 1.22e-08 | 2.55e-01 | 0.1323 |
64757 | MARC1 | P5T-E | Human | Esophagus | ESCC | 2.05e-07 | 2.10e-01 | 0.1327 |
64757 | MARC1 | P8T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.32e-02 | 0.0889 |
64757 | MARC1 | P9T-E | Human | Esophagus | ESCC | 1.45e-04 | 1.38e-01 | 0.1131 |
64757 | MARC1 | P15T-E | Human | Esophagus | ESCC | 3.26e-02 | 8.77e-02 | 0.1149 |
64757 | MARC1 | P16T-E | Human | Esophagus | ESCC | 1.23e-20 | 4.12e-01 | 0.1153 |
64757 | MARC1 | P19T-E | Human | Esophagus | ESCC | 6.53e-04 | 2.71e-01 | 0.1662 |
64757 | MARC1 | P20T-E | Human | Esophagus | ESCC | 5.73e-03 | 9.65e-02 | 0.1124 |
64757 | MARC1 | P22T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.25e-01 | 0.1236 |
64757 | MARC1 | P23T-E | Human | Esophagus | ESCC | 2.24e-15 | 3.70e-01 | 0.108 |
64757 | MARC1 | P24T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.77e-01 | 0.1287 |
64757 | MARC1 | P28T-E | Human | Esophagus | ESCC | 3.58e-28 | 5.33e-01 | 0.1149 |
64757 | MARC1 | P30T-E | Human | Esophagus | ESCC | 2.19e-27 | 1.05e+00 | 0.137 |
64757 | MARC1 | P31T-E | Human | Esophagus | ESCC | 2.05e-07 | 1.50e-01 | 0.1251 |
64757 | MARC1 | P36T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.67e-01 | 0.1187 |
64757 | MARC1 | P37T-E | Human | Esophagus | ESCC | 2.31e-05 | 1.33e-01 | 0.1371 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MARC1 | SNV | Missense_Mutation | c.926G>A | p.Gly309Glu | p.G309E | Q5VT66 | protein_coding | tolerated(0.09) | possibly_damaging(0.542) | TCGA-A2-A0EU-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MARC1 | SNV | Missense_Mutation | c.580C>G | p.Gln194Glu | p.Q194E | Q5VT66 | protein_coding | tolerated(1) | benign(0.01) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR | |
MARC1 | insertion | In_Frame_Ins | novel | c.903_904insAGGATGGTCTTGATCTCCATCCTGGTTGTGATCTGCCAGCCTCGG | p.Asp301_Pro302insArgMetValLeuIleSerIleLeuValValIleCysGlnProArg | p.D301_P302insRMVLISILVVICQPR | Q5VT66 | protein_coding | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | ||
MARC1 | insertion | Nonsense_Mutation | novel | c.945_946insTCTTAATGCCGAAAGGGGGAA | p.Gly315_Gln316insSerTerCysArgLysGlyGlu | p.G315_Q316insS*CRKGE | Q5VT66 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
MARC1 | SNV | Missense_Mutation | rs768455140 | c.784N>A | p.Val262Met | p.V262M | Q5VT66 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3952-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MARC1 | SNV | Missense_Mutation | c.388T>G | p.Tyr130Asp | p.Y130D | Q5VT66 | protein_coding | tolerated(0.38) | benign(0.003) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |
MARC1 | SNV | Missense_Mutation | novel | c.352N>C | p.Thr118Pro | p.T118P | Q5VT66 | protein_coding | deleterious(0.03) | probably_damaging(0.972) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
MARC1 | SNV | Missense_Mutation | c.437T>C | p.Val146Ala | p.V146A | Q5VT66 | protein_coding | deleterious(0) | possibly_damaging(0.796) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MARC1 | insertion | Frame_Shift_Ins | novel | c.1011_1012insCT | p.Ter338LeufsTer40 | p.*338Lfs*40 | Q5VT66 | protein_coding | TCGA-AG-3728-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | ||
MARC1 | SNV | Missense_Mutation | novel | c.396N>T | p.Lys132Asn | p.K132N | Q5VT66 | protein_coding | tolerated(0.16) | benign(0.038) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |