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Gene: MAPK8IP2 |
Gene summary for MAPK8IP2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MAPK8IP2 | Gene ID | 23542 |
| Gene name | mitogen-activated protein kinase 8 interacting protein 2 | |
| Gene Alias | IB-2 | |
| Cytomap | 22q13.33 | |
| Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q13387 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23542 | MAPK8IP2 | HCC1_Meng | Human | Liver | HCC | 4.58e-11 | 3.65e-02 | 0.0246 |
| 23542 | MAPK8IP2 | HCC2 | Human | Liver | HCC | 2.06e-27 | 3.47e+00 | 0.5341 |
| 23542 | MAPK8IP2 | S015 | Human | Liver | HCC | 1.31e-05 | 2.95e-01 | 0.2375 |
| 23542 | MAPK8IP2 | S016 | Human | Liver | HCC | 4.05e-10 | 3.41e-01 | 0.2243 |
| 23542 | MAPK8IP2 | S027 | Human | Liver | HCC | 2.78e-14 | 7.44e-01 | 0.2446 |
| 23542 | MAPK8IP2 | S028 | Human | Liver | HCC | 5.55e-24 | 7.19e-01 | 0.2503 |
| 23542 | MAPK8IP2 | S029 | Human | Liver | HCC | 3.57e-22 | 6.00e-01 | 0.2581 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:200123322 | Liver | HCC | regulation of apoptotic signaling pathway | 226/7958 | 356/18723 | 7.26e-16 | 5.68e-14 | 226 |
| GO:200123412 | Liver | HCC | negative regulation of apoptotic signaling pathway | 145/7958 | 224/18723 | 1.33e-11 | 5.36e-10 | 145 |
| GO:003109822 | Liver | HCC | stress-activated protein kinase signaling cascade | 138/7958 | 247/18723 | 1.43e-05 | 1.57e-04 | 138 |
| GO:005140322 | Liver | HCC | stress-activated MAPK cascade | 134/7958 | 239/18723 | 1.50e-05 | 1.64e-04 | 134 |
| GO:007030222 | Liver | HCC | regulation of stress-activated protein kinase signaling cascade | 105/7958 | 195/18723 | 8.79e-04 | 5.20e-03 | 105 |
| GO:003287222 | Liver | HCC | regulation of stress-activated MAPK cascade | 102/7958 | 192/18723 | 1.86e-03 | 9.49e-03 | 102 |
| GO:000725412 | Liver | HCC | JNK cascade | 89/7958 | 167/18723 | 3.09e-03 | 1.44e-02 | 89 |
| GO:001635811 | Liver | HCC | dendrite development | 121/7958 | 243/18723 | 1.26e-02 | 4.56e-02 | 121 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MAPK8IP2 | SNV | Missense_Mutation | rs756689462 | c.2327N>C | p.His776Pro | p.H776P | Q13387 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A7-A13D-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
| MAPK8IP2 | SNV | Missense_Mutation | rs771635327 | c.190C>T | p.Arg64Cys | p.R64C | Q13387 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MAPK8IP2 | SNV | Missense_Mutation | novel | c.2383N>A | p.Pro795Thr | p.P795T | Q13387 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-BH-A1EY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| MAPK8IP2 | SNV | Missense_Mutation | novel | c.1843T>C | p.Phe615Leu | p.F615L | Q13387 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD |
| MAPK8IP2 | SNV | Missense_Mutation | novel | c.2383N>A | p.Pro795Thr | p.P795T | Q13387 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-E2-A1L6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD |
| MAPK8IP2 | insertion | Frame_Shift_Ins | novel | c.330_331insTTTTTTGAGATGGGATCTCACTCTGCCCCCCA | p.Gly111PhefsTer44 | p.G111Ffs*44 | Q13387 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
| MAPK8IP2 | SNV | Missense_Mutation | rs749514444 | c.2194C>T | p.Arg732Trp | p.R732W | Q13387 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
| MAPK8IP2 | SNV | Missense_Mutation | c.484N>T | p.Arg162Cys | p.R162C | Q13387 | protein_coding | deleterious(0.01) | benign(0.039) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| MAPK8IP2 | SNV | Missense_Mutation | c.437T>C | p.Leu146Pro | p.L146P | Q13387 | protein_coding | tolerated(0.14) | benign(0.018) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| MAPK8IP2 | SNV | Missense_Mutation | novel | c.2203N>G | p.Lys735Glu | p.K735E | Q13387 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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