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Gene: MAP7D1 |
Gene summary for MAP7D1 |
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Gene information | Species | Human | Gene symbol | MAP7D1 | Gene ID | 55700 |
Gene name | MAP7 domain containing 1 | |
Gene Alias | PARCC1 | |
Cytomap | 1p34.3 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q3KQU3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55700 | MAP7D1 | LZE4T | Human | Esophagus | ESCC | 1.46e-05 | -1.63e-01 | 0.0811 |
55700 | MAP7D1 | LZE5T | Human | Esophagus | ESCC | 1.19e-02 | -1.05e-01 | 0.0514 |
55700 | MAP7D1 | LZE8T | Human | Esophagus | ESCC | 1.23e-03 | -1.52e-01 | 0.067 |
55700 | MAP7D1 | LZE22T | Human | Esophagus | ESCC | 6.62e-05 | 3.31e-01 | 0.068 |
55700 | MAP7D1 | LZE24T | Human | Esophagus | ESCC | 1.07e-06 | 3.23e-01 | 0.0596 |
55700 | MAP7D1 | LZE6T | Human | Esophagus | ESCC | 3.15e-03 | -2.63e-01 | 0.0845 |
55700 | MAP7D1 | P1T-E | Human | Esophagus | ESCC | 4.16e-03 | 4.16e-01 | 0.0875 |
55700 | MAP7D1 | P2T-E | Human | Esophagus | ESCC | 1.06e-12 | 2.64e-01 | 0.1177 |
55700 | MAP7D1 | P4T-E | Human | Esophagus | ESCC | 7.55e-11 | 3.74e-01 | 0.1323 |
55700 | MAP7D1 | P5T-E | Human | Esophagus | ESCC | 1.28e-20 | 5.36e-01 | 0.1327 |
55700 | MAP7D1 | P8T-E | Human | Esophagus | ESCC | 1.05e-11 | 1.26e-01 | 0.0889 |
55700 | MAP7D1 | P9T-E | Human | Esophagus | ESCC | 1.11e-02 | 1.97e-01 | 0.1131 |
55700 | MAP7D1 | P10T-E | Human | Esophagus | ESCC | 2.15e-21 | 4.18e-01 | 0.116 |
55700 | MAP7D1 | P11T-E | Human | Esophagus | ESCC | 4.32e-16 | 1.02e+00 | 0.1426 |
55700 | MAP7D1 | P12T-E | Human | Esophagus | ESCC | 2.70e-13 | 1.09e-01 | 0.1122 |
55700 | MAP7D1 | P15T-E | Human | Esophagus | ESCC | 1.11e-04 | 2.19e-01 | 0.1149 |
55700 | MAP7D1 | P16T-E | Human | Esophagus | ESCC | 1.72e-14 | -2.06e-01 | 0.1153 |
55700 | MAP7D1 | P17T-E | Human | Esophagus | ESCC | 3.87e-04 | 4.17e-01 | 0.1278 |
55700 | MAP7D1 | P19T-E | Human | Esophagus | ESCC | 5.19e-06 | 7.80e-01 | 0.1662 |
55700 | MAP7D1 | P20T-E | Human | Esophagus | ESCC | 1.31e-06 | 2.18e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP7D1 | SNV | Missense_Mutation | c.2509N>T | p.Val837Phe | p.V837F | Q3KQU3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A08B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
MAP7D1 | SNV | Missense_Mutation | novel | c.1722G>T | p.Leu574Phe | p.L574F | Q3KQU3 | protein_coding | tolerated(0.69) | benign(0.185) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAP7D1 | SNV | Missense_Mutation | c.304G>A | p.Gly102Ser | p.G102S | Q3KQU3 | protein_coding | tolerated(0.14) | probably_damaging(0.994) | TCGA-AR-A1AI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | PD | |
MAP7D1 | deletion | Frame_Shift_Del | rs764795709 | c.62delN | p.Pro23GlnfsTer33 | p.P23Qfs*33 | Q3KQU3 | protein_coding | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | ||
MAP7D1 | SNV | Missense_Mutation | rs552661941 | c.215N>T | p.Ser72Leu | p.S72L | Q3KQU3 | protein_coding | tolerated_low_confidence(0.32) | benign(0.057) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
MAP7D1 | deletion | Frame_Shift_Del | c.1440delC | p.Cys481AlafsTer94 | p.C481Afs*94 | Q3KQU3 | protein_coding | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |||
MAP7D1 | SNV | Missense_Mutation | c.1441T>A | p.Cys481Ser | p.C481S | Q3KQU3 | protein_coding | tolerated(0.63) | probably_damaging(0.977) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAP7D1 | SNV | Missense_Mutation | c.2250G>T | p.Glu750Asp | p.E750D | Q3KQU3 | protein_coding | tolerated(0.16) | benign(0.003) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MAP7D1 | SNV | Missense_Mutation | c.805C>T | p.Arg269Trp | p.R269W | Q3KQU3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
MAP7D1 | SNV | Missense_Mutation | c.1465N>G | p.Thr489Ala | p.T489A | Q3KQU3 | protein_coding | tolerated(1) | benign(0.006) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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