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Gene: MANSC1 |
Gene summary for MANSC1 |
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Gene information | Species | Human | Gene symbol | MANSC1 | Gene ID | 54682 |
Gene name | MANSC domain containing 1 | |
Gene Alias | 9130403P13Rik | |
Cytomap | 12p13.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9H8J5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54682 | MANSC1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.71e-06 | 3.07e-01 | -0.1808 |
54682 | MANSC1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.87e-05 | 3.15e-01 | -0.0811 |
54682 | MANSC1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.77e-05 | 2.39e-01 | -0.1088 |
54682 | MANSC1 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.64e-14 | 3.96e-01 | -0.1954 |
54682 | MANSC1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.89e-05 | 2.89e-01 | -0.059 |
54682 | MANSC1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.07e-04 | 2.09e-01 | 0.096 |
54682 | MANSC1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 5.59e-13 | 4.16e-01 | 0.294 |
54682 | MANSC1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.34e-04 | 8.00e-01 | 0.3487 |
54682 | MANSC1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.63e-02 | 1.93e-01 | 0.281 |
54682 | MANSC1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.57e-13 | 5.27e-01 | 0.3859 |
54682 | MANSC1 | LZE8T | Human | Esophagus | ESCC | 5.94e-03 | 1.57e-01 | 0.067 |
54682 | MANSC1 | LZE24T | Human | Esophagus | ESCC | 7.72e-12 | 1.53e-01 | 0.0596 |
54682 | MANSC1 | P2T-E | Human | Esophagus | ESCC | 9.93e-07 | 1.18e-01 | 0.1177 |
54682 | MANSC1 | P4T-E | Human | Esophagus | ESCC | 8.26e-30 | 9.16e-01 | 0.1323 |
54682 | MANSC1 | P8T-E | Human | Esophagus | ESCC | 4.61e-16 | 3.86e-01 | 0.0889 |
54682 | MANSC1 | P9T-E | Human | Esophagus | ESCC | 1.54e-11 | 1.39e-01 | 0.1131 |
54682 | MANSC1 | P10T-E | Human | Esophagus | ESCC | 1.65e-11 | 1.71e-01 | 0.116 |
54682 | MANSC1 | P12T-E | Human | Esophagus | ESCC | 1.41e-10 | 3.51e-01 | 0.1122 |
54682 | MANSC1 | P15T-E | Human | Esophagus | ESCC | 7.17e-04 | 2.57e-01 | 0.1149 |
54682 | MANSC1 | P16T-E | Human | Esophagus | ESCC | 1.24e-59 | 1.62e+00 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MANSC1 | SNV | Missense_Mutation | c.994A>G | p.Thr332Ala | p.T332A | Q9H8J5 | protein_coding | tolerated(0.62) | benign(0) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MANSC1 | insertion | Nonsense_Mutation | novel | c.1002_1003insATTAGCTGAAAACAAAGCTCTATGTAAA | p.Val335IlefsTer3 | p.V335Ifs*3 | Q9H8J5 | protein_coding | TCGA-A2-A0CM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD | ||
MANSC1 | insertion | In_Frame_Ins | novel | c.578_579insTCAAACATCCTCTCTCCGTATTTTACCAACACG | p.Gln194_Leu195insThrSerSerLeuArgIleLeuProThrArgGln | p.Q194_L195insTSSLRILPTRQ | Q9H8J5 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
MANSC1 | SNV | Missense_Mutation | c.249N>G | p.Ile83Met | p.I83M | Q9H8J5 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EX-A1H6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
MANSC1 | SNV | Missense_Mutation | c.1060A>G | p.Thr354Ala | p.T354A | Q9H8J5 | protein_coding | deleterious(0.05) | benign(0.007) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MANSC1 | SNV | Missense_Mutation | c.1156N>A | p.Leu386Ile | p.L386I | Q9H8J5 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MANSC1 | SNV | Missense_Mutation | novel | c.1043N>A | p.Ser348Tyr | p.S348Y | Q9H8J5 | protein_coding | deleterious(0) | possibly_damaging(0.498) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MANSC1 | SNV | Missense_Mutation | c.113N>C | p.Val38Ala | p.V38A | Q9H8J5 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MANSC1 | SNV | Missense_Mutation | c.326N>G | p.Lys109Arg | p.K109R | Q9H8J5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
MANSC1 | SNV | Missense_Mutation | rs760114487 | c.100C>A | p.Leu34Ile | p.L34I | Q9H8J5 | protein_coding | deleterious(0.02) | probably_damaging(0.985) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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