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Gene: MANBAL |
Gene summary for MANBAL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MANBAL | Gene ID | 63905 |
| Gene name | mannosidase beta like | |
| Gene Alias | MANBAL | |
| Cytomap | 20q11.23 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NQG1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 63905 | MANBAL | LZE4T | Human | Esophagus | ESCC | 5.51e-15 | 4.47e-01 | 0.0811 |
| 63905 | MANBAL | LZE7T | Human | Esophagus | ESCC | 1.91e-06 | 3.93e-01 | 0.0667 |
| 63905 | MANBAL | LZE8T | Human | Esophagus | ESCC | 1.27e-09 | 2.71e-01 | 0.067 |
| 63905 | MANBAL | LZE20T | Human | Esophagus | ESCC | 6.60e-11 | 4.85e-01 | 0.0662 |
| 63905 | MANBAL | LZE22D1 | Human | Esophagus | HGIN | 2.03e-06 | 1.99e-01 | 0.0595 |
| 63905 | MANBAL | LZE24T | Human | Esophagus | ESCC | 6.33e-26 | 8.83e-01 | 0.0596 |
| 63905 | MANBAL | LZE21T | Human | Esophagus | ESCC | 9.57e-06 | 3.40e-01 | 0.0655 |
| 63905 | MANBAL | P1T-E | Human | Esophagus | ESCC | 3.47e-09 | 6.72e-01 | 0.0875 |
| 63905 | MANBAL | P2T-E | Human | Esophagus | ESCC | 1.21e-34 | 6.57e-01 | 0.1177 |
| 63905 | MANBAL | P4T-E | Human | Esophagus | ESCC | 4.91e-41 | 1.08e+00 | 0.1323 |
| 63905 | MANBAL | P5T-E | Human | Esophagus | ESCC | 4.94e-11 | 3.57e-01 | 0.1327 |
| 63905 | MANBAL | P8T-E | Human | Esophagus | ESCC | 3.72e-40 | 7.84e-01 | 0.0889 |
| 63905 | MANBAL | P9T-E | Human | Esophagus | ESCC | 1.86e-22 | 5.52e-01 | 0.1131 |
| 63905 | MANBAL | P10T-E | Human | Esophagus | ESCC | 1.29e-69 | 1.25e+00 | 0.116 |
| 63905 | MANBAL | P11T-E | Human | Esophagus | ESCC | 2.95e-32 | 1.25e+00 | 0.1426 |
| 63905 | MANBAL | P12T-E | Human | Esophagus | ESCC | 9.52e-54 | 1.04e+00 | 0.1122 |
| 63905 | MANBAL | P15T-E | Human | Esophagus | ESCC | 2.55e-44 | 8.57e-01 | 0.1149 |
| 63905 | MANBAL | P16T-E | Human | Esophagus | ESCC | 2.50e-38 | 9.60e-01 | 0.1153 |
| 63905 | MANBAL | P17T-E | Human | Esophagus | ESCC | 5.82e-10 | 6.28e-01 | 0.1278 |
| 63905 | MANBAL | P19T-E | Human | Esophagus | ESCC | 9.43e-07 | 1.10e+00 | 0.1662 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MANBAL | SNV | Missense_Mutation | rs139446010 | c.67N>T | p.Arg23Trp | p.R23W | Q9NQG1 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
| MANBAL | SNV | Missense_Mutation | c.74N>A | p.Gly25Glu | p.G25E | Q9NQG1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MANBAL | SNV | Missense_Mutation | rs139446010 | c.67N>T | p.Arg23Trp | p.R23W | Q9NQG1 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| MANBAL | SNV | Missense_Mutation | rs755003934 | c.29N>T | p.Pro10Leu | p.P10L | Q9NQG1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
| MANBAL | SNV | Missense_Mutation | novel | c.201N>T | p.Lys67Asn | p.K67N | Q9NQG1 | protein_coding | deleterious(0.02) | possibly_damaging(0.587) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| MANBAL | SNV | Missense_Mutation | rs777773368 | c.124G>A | p.Val42Ile | p.V42I | Q9NQG1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| MANBAL | SNV | Missense_Mutation | rs777773368 | c.124G>A | p.Val42Ile | p.V42I | Q9NQG1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MANBAL | SNV | Missense_Mutation | rs747541266 | c.145N>A | p.Glu49Lys | p.E49K | Q9NQG1 | protein_coding | tolerated(0.32) | benign(0.265) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
| MANBAL | SNV | Missense_Mutation | rs755003934 | c.29C>T | p.Pro10Leu | p.P10L | Q9NQG1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-18-3407-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| MANBAL | SNV | Missense_Mutation | c.230N>T | p.Pro77Leu | p.P77L | Q9NQG1 | protein_coding | tolerated(0.22) | benign(0.144) | TCGA-63-5131-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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