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Gene: MAGED2 |
Gene summary for MAGED2 |
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Gene information | Species | Human | Gene symbol | MAGED2 | Gene ID | 10916 |
Gene name | MAGE family member D2 | |
Gene Alias | 11B6 | |
Cytomap | Xp11.21 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R9Y7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10916 | MAGED2 | GSM4909281 | Human | Breast | IDC | 8.27e-07 | 3.77e-01 | 0.21 |
10916 | MAGED2 | GSM4909285 | Human | Breast | IDC | 1.06e-02 | 2.24e-01 | 0.21 |
10916 | MAGED2 | GSM4909290 | Human | Breast | IDC | 1.71e-04 | 3.24e-01 | 0.2096 |
10916 | MAGED2 | GSM4909291 | Human | Breast | IDC | 8.64e-03 | 3.19e-01 | 0.1753 |
10916 | MAGED2 | GSM4909293 | Human | Breast | IDC | 2.73e-27 | 6.17e-01 | 0.1581 |
10916 | MAGED2 | GSM4909294 | Human | Breast | IDC | 1.30e-24 | 5.53e-01 | 0.2022 |
10916 | MAGED2 | GSM4909295 | Human | Breast | IDC | 3.84e-03 | 3.74e-01 | 0.0898 |
10916 | MAGED2 | GSM4909296 | Human | Breast | IDC | 8.33e-04 | -1.25e-01 | 0.1524 |
10916 | MAGED2 | GSM4909297 | Human | Breast | IDC | 7.92e-32 | 6.61e-01 | 0.1517 |
10916 | MAGED2 | GSM4909301 | Human | Breast | IDC | 5.76e-07 | 4.33e-01 | 0.1577 |
10916 | MAGED2 | GSM4909303 | Human | Breast | IDC | 4.15e-05 | 5.02e-01 | 0.0438 |
10916 | MAGED2 | GSM4909304 | Human | Breast | IDC | 1.05e-04 | 3.14e-01 | 0.1636 |
10916 | MAGED2 | GSM4909305 | Human | Breast | IDC | 4.50e-11 | 4.93e-01 | 0.0436 |
10916 | MAGED2 | GSM4909306 | Human | Breast | IDC | 6.38e-64 | 1.08e+00 | 0.1564 |
10916 | MAGED2 | GSM4909307 | Human | Breast | IDC | 4.19e-09 | 4.31e-01 | 0.1569 |
10916 | MAGED2 | GSM4909308 | Human | Breast | IDC | 2.24e-40 | 7.90e-01 | 0.158 |
10916 | MAGED2 | GSM4909311 | Human | Breast | IDC | 1.59e-20 | 1.16e-01 | 0.1534 |
10916 | MAGED2 | GSM4909312 | Human | Breast | IDC | 4.76e-13 | 4.77e-01 | 0.1552 |
10916 | MAGED2 | GSM4909313 | Human | Breast | IDC | 7.11e-08 | 3.69e-01 | 0.0391 |
10916 | MAGED2 | GSM4909317 | Human | Breast | IDC | 1.76e-05 | 2.94e-01 | 0.1355 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00075653 | Breast | Precancer | female pregnancy | 29/1080 | 193/18723 | 2.07e-06 | 7.31e-05 | 29 |
GO:00447063 | Breast | Precancer | multi-multicellular organism process | 31/1080 | 220/18723 | 3.73e-06 | 1.19e-04 | 31 |
GO:00702933 | Breast | Precancer | renal absorption | 6/1080 | 17/18723 | 2.59e-04 | 3.83e-03 | 6 |
GO:000756511 | Breast | IDC | female pregnancy | 39/1434 | 193/18723 | 1.81e-08 | 1.27e-06 | 39 |
GO:00447061 | Breast | IDC | multi-multicellular organism process | 41/1434 | 220/18723 | 8.58e-08 | 5.19e-06 | 41 |
GO:007029311 | Breast | IDC | renal absorption | 6/1434 | 17/18723 | 1.18e-03 | 1.28e-02 | 6 |
GO:00075652 | Breast | DCIS | female pregnancy | 37/1390 | 193/18723 | 7.85e-08 | 4.47e-06 | 37 |
GO:00447062 | Breast | DCIS | multi-multicellular organism process | 39/1390 | 220/18723 | 3.05e-07 | 1.46e-05 | 39 |
GO:007029321 | Breast | DCIS | renal absorption | 6/1390 | 17/18723 | 1.00e-03 | 1.11e-02 | 6 |
GO:00030144 | Breast | DCIS | renal system process | 16/1390 | 110/18723 | 7.16e-03 | 4.85e-02 | 16 |
GO:0003014 | Colorectum | AD | renal system process | 35/3918 | 110/18723 | 4.85e-03 | 3.27e-02 | 35 |
GO:00030141 | Colorectum | SER | renal system process | 30/2897 | 110/18723 | 1.05e-03 | 1.22e-02 | 30 |
GO:00075655 | Endometrium | AEH | female pregnancy | 43/2100 | 193/18723 | 7.52e-06 | 1.80e-04 | 43 |
GO:00447065 | Endometrium | AEH | multi-multicellular organism process | 45/2100 | 220/18723 | 4.55e-05 | 7.61e-04 | 45 |
GO:000756513 | Endometrium | EEC | female pregnancy | 43/2168 | 193/18723 | 1.66e-05 | 3.18e-04 | 43 |
GO:004470612 | Endometrium | EEC | multi-multicellular organism process | 45/2168 | 220/18723 | 9.73e-05 | 1.35e-03 | 45 |
GO:0007565 | Liver | Cirrhotic | female pregnancy | 65/4634 | 193/18723 | 3.21e-03 | 1.80e-02 | 65 |
GO:0044706 | Liver | Cirrhotic | multi-multicellular organism process | 70/4634 | 220/18723 | 1.03e-02 | 4.61e-02 | 70 |
GO:00075651 | Liver | HCC | female pregnancy | 99/7958 | 193/18723 | 8.24e-03 | 3.23e-02 | 99 |
GO:00075657 | Oral cavity | OSCC | female pregnancy | 98/7305 | 193/18723 | 5.66e-04 | 3.27e-03 | 98 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAGED2 | SNV | Missense_Mutation | c.556G>C | p.Glu186Gln | p.E186Q | Q9UNF1 | protein_coding | deleterious(0.01) | probably_damaging(0.968) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
MAGED2 | SNV | Missense_Mutation | rs747287337 | c.799N>C | p.Glu267Gln | p.E267Q | Q9UNF1 | protein_coding | tolerated(0.06) | possibly_damaging(0.889) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
MAGED2 | SNV | Missense_Mutation | novel | c.1726A>C | p.Thr576Pro | p.T576P | Q9UNF1 | protein_coding | tolerated_low_confidence(0.19) | benign(0.001) | TCGA-B6-A1KN-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MAGED2 | insertion | Frame_Shift_Ins | novel | c.1374_1375insT | p.Ala460CysfsTer29 | p.A460Cfs*29 | Q9UNF1 | protein_coding | TCGA-AO-A0JF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | ||
MAGED2 | deletion | Frame_Shift_Del | novel | c.1494delG | p.Ile499LeufsTer77 | p.I499Lfs*77 | Q9UNF1 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MAGED2 | SNV | Missense_Mutation | rs201160051 | c.128N>T | p.Pro43Leu | p.P43L | Q9UNF1 | protein_coding | deleterious_low_confidence(0.05) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAGED2 | SNV | Missense_Mutation | novel | c.1753N>A | p.Ala585Thr | p.A585T | Q9UNF1 | protein_coding | tolerated_low_confidence(0.14) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MAGED2 | SNV | Missense_Mutation | novel | c.1140N>G | p.Phe380Leu | p.F380L | Q9UNF1 | protein_coding | deleterious(0.02) | probably_damaging(0.964) | TCGA-C5-A8YR-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
MAGED2 | SNV | Missense_Mutation | rs779634966 | c.1462G>A | p.Glu488Lys | p.E488K | Q9UNF1 | protein_coding | tolerated(0.34) | possibly_damaging(0.593) | TCGA-EK-A3GM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
MAGED2 | SNV | Missense_Mutation | c.1202N>A | p.Arg401His | p.R401H | Q9UNF1 | protein_coding | tolerated(0.15) | benign(0.028) | TCGA-FU-A3NI-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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