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Gene: MAFK |
Gene summary for MAFK |
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Gene information | Species | Human | Gene symbol | MAFK | Gene ID | 7975 |
Gene name | MAF bZIP transcription factor K | |
Gene Alias | NFE2U | |
Cytomap | 7p22.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A0A024R804 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7975 | MAFK | LZE4T | Human | Esophagus | ESCC | 3.30e-05 | -6.00e-02 | 0.0811 |
7975 | MAFK | LZE5T | Human | Esophagus | ESCC | 6.83e-04 | 7.04e-02 | 0.0514 |
7975 | MAFK | LZE7T | Human | Esophagus | ESCC | 5.39e-05 | -6.09e-02 | 0.0667 |
7975 | MAFK | LZE8T | Human | Esophagus | ESCC | 8.96e-08 | -9.17e-02 | 0.067 |
7975 | MAFK | LZE20T | Human | Esophagus | ESCC | 1.15e-03 | 7.86e-02 | 0.0662 |
7975 | MAFK | LZE24T | Human | Esophagus | ESCC | 1.90e-12 | 1.23e-01 | 0.0596 |
7975 | MAFK | P2T-E | Human | Esophagus | ESCC | 2.80e-12 | -1.51e-01 | 0.1177 |
7975 | MAFK | P4T-E | Human | Esophagus | ESCC | 2.69e-17 | -8.93e-02 | 0.1323 |
7975 | MAFK | P5T-E | Human | Esophagus | ESCC | 6.52e-19 | -1.31e-02 | 0.1327 |
7975 | MAFK | P8T-E | Human | Esophagus | ESCC | 5.16e-09 | 2.86e-01 | 0.0889 |
7975 | MAFK | P9T-E | Human | Esophagus | ESCC | 9.08e-07 | 1.21e-01 | 0.1131 |
7975 | MAFK | P10T-E | Human | Esophagus | ESCC | 1.51e-06 | -6.60e-02 | 0.116 |
7975 | MAFK | P12T-E | Human | Esophagus | ESCC | 4.74e-17 | -6.10e-02 | 0.1122 |
7975 | MAFK | P15T-E | Human | Esophagus | ESCC | 8.93e-15 | -1.40e-01 | 0.1149 |
7975 | MAFK | P16T-E | Human | Esophagus | ESCC | 2.04e-07 | -2.51e-01 | 0.1153 |
7975 | MAFK | P20T-E | Human | Esophagus | ESCC | 3.95e-14 | -5.39e-02 | 0.1124 |
7975 | MAFK | P21T-E | Human | Esophagus | ESCC | 1.44e-11 | -6.16e-02 | 0.1617 |
7975 | MAFK | P22T-E | Human | Esophagus | ESCC | 1.14e-09 | -1.56e-01 | 0.1236 |
7975 | MAFK | P23T-E | Human | Esophagus | ESCC | 2.27e-07 | 2.73e-01 | 0.108 |
7975 | MAFK | P24T-E | Human | Esophagus | ESCC | 2.25e-06 | -1.23e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAFK | SNV | Missense_Mutation | c.169N>T | p.Arg57Cys | p.R57C | O60675 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
MAFK | SNV | Missense_Mutation | rs768259709 | c.322C>T | p.Arg108Cys | p.R108C | O60675 | protein_coding | deleterious(0.02) | probably_damaging(0.973) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MAFK | SNV | Missense_Mutation | novel | c.167G>A | p.Arg56Gln | p.R56Q | O60675 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAFK | SNV | Missense_Mutation | novel | c.240G>C | p.Glu80Asp | p.E80D | O60675 | protein_coding | deleterious(0.04) | benign(0.173) | TCGA-BG-A222-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MAFK | SNV | Missense_Mutation | novel | c.50N>T | p.Ala17Val | p.A17V | O60675 | protein_coding | tolerated(0.61) | benign(0) | TCGA-BG-A2L7-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
MAFK | SNV | Missense_Mutation | rs865915761 | c.170N>A | p.Arg57His | p.R57H | O60675 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MAFK | SNV | Missense_Mutation | novel | c.247N>A | p.Arg83Ser | p.R83S | O60675 | protein_coding | deleterious(0) | possibly_damaging(0.46) | TCGA-DI-A1BU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
MAFK | SNV | Missense_Mutation | novel | c.464C>T | p.Ala155Val | p.A155V | O60675 | protein_coding | deleterious_low_confidence(0.03) | benign(0.018) | TCGA-EY-A1GQ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | taxol | SD |
MAFK | SNV | Missense_Mutation | rs561433493 | c.5N>T | p.Thr2Met | p.T2M | O60675 | protein_coding | deleterious_low_confidence(0.04) | benign(0.078) | TCGA-QS-A5YR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7975 | MAFK | ENZYME, TRANSCRIPTION FACTOR | isoniazid | ISONIAZID | 22341855,29036176 |
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