Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MAFG

Gene summary for MAFG

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MAFG

Gene ID

4097

Gene nameMAF bZIP transcription factor G
Gene AliashMAF
Cytomap17q25.3
Gene Typeprotein-coding
GO ID

GO:0001701

UniProtAcc

A0A024R8X1


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
4097MAFGHTA11_3410_2000001011HumanColorectumAD6.02e-072.13e-010.0155
4097MAFGHTA11_2487_2000001011HumanColorectumSER9.60e-074.70e-01-0.1808
4097MAFGHTA11_1938_2000001011HumanColorectumAD8.96e-085.24e-01-0.0811
4097MAFGHTA11_78_2000001011HumanColorectumAD7.84e-042.69e-01-0.1088
4097MAFGHTA11_347_2000001011HumanColorectumAD1.19e-073.04e-01-0.1954
4097MAFGHTA11_411_2000001011HumanColorectumSER1.69e-037.44e-01-0.2602
4097MAFGHTA11_3361_2000001011HumanColorectumAD2.63e-022.93e-01-0.1207
4097MAFGHTA11_83_2000001011HumanColorectumSER1.66e-105.60e-01-0.1526
4097MAFGHTA11_696_2000001011HumanColorectumAD2.78e-124.08e-01-0.1464
4097MAFGHTA11_866_2000001011HumanColorectumAD1.29e-041.95e-01-0.1001
4097MAFGHTA11_1391_2000001011HumanColorectumAD3.52e-104.32e-01-0.059
4097MAFGHTA11_5212_2000001011HumanColorectumAD1.08e-023.46e-01-0.2061
4097MAFGHTA11_7862_2000001011HumanColorectumAD1.60e-022.82e-01-0.0179
4097MAFGHTA11_866_3004761011HumanColorectumAD1.18e-103.92e-010.096
4097MAFGHTA11_8622_2000001021HumanColorectumSER4.26e-033.46e-010.0528
4097MAFGHTA11_7696_3000711011HumanColorectumAD5.08e-062.36e-010.0674
4097MAFGHTA11_6818_2000001011HumanColorectumAD3.26e-033.85e-010.0112
4097MAFGHTA11_6818_2000001021HumanColorectumAD2.17e-033.31e-010.0588
4097MAFGHTA11_99999970781_79442HumanColorectumMSS5.22e-205.86e-010.294
4097MAFGHTA11_99999965062_69753HumanColorectumMSI-H1.06e-047.92e-010.3487
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0001701ColorectumADin utero embryonic development110/3918367/187232.36e-054.62e-04110
GO:0030004ColorectumADcellular monovalent inorganic cation homeostasis36/3918103/187236.80e-046.95e-0336
GO:0030641ColorectumADregulation of cellular pH29/391881/187231.42e-031.22e-0229
GO:0006885ColorectumADregulation of pH30/391891/187234.95e-033.32e-0230
GO:0009913ColorectumADepidermal cell differentiation58/3918202/187235.16e-033.42e-0258
GO:0008544ColorectumADepidermis development87/3918324/187235.99e-033.76e-0287
GO:0055067ColorectumADmonovalent inorganic cation homeostasis45/3918151/187236.19e-033.88e-0245
GO:00300041ColorectumSERcellular monovalent inorganic cation homeostasis31/2897103/187231.31e-042.66e-0331
GO:00306411ColorectumSERregulation of cellular pH24/289781/187239.20e-041.11e-0224
GO:00550671ColorectumSERmonovalent inorganic cation homeostasis37/2897151/187232.48e-032.33e-0237
GO:00017011ColorectumSERin utero embryonic development77/2897367/187232.77e-032.48e-0277
GO:00068851ColorectumSERregulation of pH24/289791/187235.03e-033.88e-0224
GO:00017012ColorectumMSSin utero embryonic development99/3467367/187233.71e-057.10e-0499
GO:00300042ColorectumMSScellular monovalent inorganic cation homeostasis31/3467103/187232.94e-032.27e-0231
GO:00306412ColorectumMSSregulation of cellular pH25/346781/187234.97e-033.46e-0225
GO:00099131ColorectumMSSepidermal cell differentiation52/3467202/187236.59e-034.38e-0252
GO:00017019EndometriumAEHin utero embryonic development73/2100367/187237.18e-072.63e-0573
GO:00308564EndometriumAEHregulation of epithelial cell differentiation33/2100154/187231.81e-042.32e-0333
GO:00456823EndometriumAEHregulation of epidermis development16/210065/187231.81e-031.44e-0216
GO:00456043EndometriumAEHregulation of epidermal cell differentiation14/210058/187234.12e-032.73e-0214
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
MAFGMONColorectumMSI-HOGFR,SLC12A7,FUCA1, etc.5.11e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
MAFGENDColorectumSERCD320,ADAM15,RAMP3, etc.5.46e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
MAFGMVALiverHCCDLG4,C17orf70,MIR24-2, etc.3.99e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
MAFGPFIBLiverHCCDLG4,C17orf70,MIR24-2, etc.1.59e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
MAFGMVALiverHealthyDLG4,C17orf70,MIR24-2, etc.5.21e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
MAFGCAFStomachCAGGLTSCR2,NHP2L1,SLC25A48, etc.3.02e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MAFGSNVMissense_Mutationnovelc.356N>Ap.Arg119Glnp.R119QO15525protein_codingdeleterious(0.02)benign(0.358)TCGA-AX-A1C4-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MAFGSNVMissense_Mutationc.170G>Ap.Arg57Hisp.R57HO15525protein_codingdeleterious(0)probably_damaging(0.998)TCGA-B5-A3FC-01Endometriumuterine corpus endometrioid carcinomaFemale<65I/IIUnknownUnknownSD
MAFGSNVMissense_Mutationrs772676495c.81N>Cp.Glu27Aspp.E27DO15525protein_codingtolerated(1)benign(0.003)TCGA-55-1595-01Lunglung adenocarcinomaFemale>=65I/IIUnknownUnknownSD
MAFGSNVMissense_Mutationnovelc.44N>Ap.Arg15Glnp.R15QO15525protein_codingtolerated(0.13)benign(0.081)TCGA-MP-A4SW-01Lunglung adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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