Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: MACROD2

Gene summary for MACROD2

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

MACROD2

Gene ID

140733

Gene namemono-ADP ribosylhydrolase 2
Gene AliasC20orf133
Cytomap20p12.1
Gene Typeprotein-coding
GO ID

GO:0006139

UniProtAcc

A1Z1Q3


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
140733MACROD2CCI_1HumanCervixCC2.12e-057.20e-010.528
140733MACROD2CCI_3HumanCervixCC9.96e-141.06e+000.516
140733MACROD2HTA11_3410_2000001011HumanColorectumAD1.09e-03-4.30e-010.0155
140733MACROD2HTA11_2487_2000001011HumanColorectumSER8.33e-03-5.01e-01-0.1808
140733MACROD2HTA11_3361_2000001011HumanColorectumAD5.63e-06-5.55e-01-0.1207
140733MACROD2HTA11_5212_2000001011HumanColorectumAD3.46e-03-7.78e-01-0.2061
140733MACROD2HTA11_8622_2000001021HumanColorectumSER1.81e-02-5.90e-010.0528
140733MACROD2HTA11_99999970781_79442HumanColorectumMSS1.45e-04-2.86e-010.294
140733MACROD2HTA11_99999971662_82457HumanColorectumMSS3.92e-09-4.10e-010.3859
140733MACROD2HTA11_99999973899_84307HumanColorectumMSS4.14e-05-7.38e-010.2585
140733MACROD2HTA11_99999974143_84620HumanColorectumMSS2.82e-11-4.53e-010.3005
140733MACROD2A015-C-203HumanColorectumFAP3.67e-22-4.98e-01-0.1294
140733MACROD2A014-C-040HumanColorectumFAP2.75e-03-4.50e-01-0.1184
140733MACROD2A002-C-201HumanColorectumFAP1.10e-14-5.37e-010.0324
140733MACROD2A002-C-203HumanColorectumFAP1.21e-04-3.02e-010.2786
140733MACROD2A001-C-119HumanColorectumFAP1.90e-04-4.87e-01-0.1557
140733MACROD2A001-C-108HumanColorectumFAP4.48e-14-3.44e-01-0.0272
140733MACROD2A002-C-205HumanColorectumFAP1.22e-17-5.54e-01-0.1236
140733MACROD2A001-C-104HumanColorectumFAP3.23e-03-2.67e-010.0184
140733MACROD2A015-C-006HumanColorectumFAP8.96e-10-3.46e-01-0.0994
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:007252110CervixCCpurine-containing compound metabolic process69/2311416/187236.27e-033.54e-0269
GO:0072521ColorectumADpurine-containing compound metabolic process153/3918416/187234.34e-141.01e-11153
GO:00725211ColorectumSERpurine-containing compound metabolic process113/2897416/187234.80e-105.68e-08113
GO:00725212ColorectumMSSpurine-containing compound metabolic process132/3467416/187234.13e-114.86e-09132
GO:00725214ColorectumFAPpurine-containing compound metabolic process101/2622416/187231.11e-081.33e-06101
GO:00725215ColorectumCRCpurine-containing compound metabolic process79/2078416/187231.15e-066.75e-0579
GO:007252116EndometriumAEHpurine-containing compound metabolic process71/2100416/187232.01e-042.54e-0371
GO:007252117EndometriumEECpurine-containing compound metabolic process73/2168416/187231.82e-042.24e-0373
GO:00725217LiverNAFLDpurine-containing compound metabolic process74/1882416/187237.73e-074.27e-0574
GO:007252112LiverCirrhoticpurine-containing compound metabolic process156/4634416/187233.74e-091.52e-07156
GO:19016572LiverCirrhoticglycosyl compound metabolic process37/463488/187232.70e-042.40e-0337
GO:0042278LiverCirrhoticpurine nucleoside metabolic process13/463426/187234.72e-032.48e-0213
GO:0009116LiverCirrhoticnucleoside metabolic process25/463462/187234.90e-032.56e-0225
GO:007252122LiverHCCpurine-containing compound metabolic process250/7958416/187232.26e-131.24e-11250
GO:19016571LiverHCCglycosyl compound metabolic process55/795888/187231.20e-041.01e-0355
GO:00091161LiverHCCnucleoside metabolic process37/795862/187234.73e-032.02e-0237
GO:00725218LungIACpurine-containing compound metabolic process67/2061416/187239.03e-041.11e-0267
GO:007252113LungAISpurine-containing compound metabolic process61/1849416/187231.10e-031.42e-0261
GO:007252123LungAAHpurine-containing compound metabolic process32/613416/187237.55e-061.82e-0332
GO:007252126SkinSCCISpurine-containing compound metabolic process33/919416/187234.69e-033.89e-0233
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
MACROD2SNVMissense_Mutationrs757545585c.904N>Ap.Glu302Lysp.E302KA1Z1Q3protein_codingtolerated_low_confidence(0.46)benign(0.019)TCGA-A8-A09I-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
MACROD2SNVMissense_Mutationnovelc.475N>Ap.Glu159Lysp.E159KA1Z1Q3protein_codingtolerated(0.08)possibly_damaging(0.831)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
MACROD2SNVMissense_Mutationnovelc.545N>Cp.Phe182Serp.F182SA1Z1Q3protein_codingdeleterious(0)probably_damaging(1)TCGA-D8-A1XW-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycin+cyclophosphamideSD
MACROD2insertionFrame_Shift_Insnovelc.503_504insCACCACGTp.Leu169ThrfsTer4p.L169Tfs*4A1Z1Q3protein_codingTCGA-A8-A09Q-01Breastbreast invasive carcinomaFemale>=65III/IVHormone TherapyanastrozoleSD
MACROD2insertionNonsense_Mutationnovelc.984_985insTAGCATATTTTAGCTAAAAAGTATTTTTCAp.Asp328_Gly329insTerp.D328_G329ins*A1Z1Q3protein_codingTCGA-B6-A402-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycyclophosphamidePD
MACROD2SNVMissense_Mutationnovelc.75N>Cp.Glu25Aspp.E25DA1Z1Q3protein_codingtolerated(0.22)benign(0.122)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
MACROD2insertionIn_Frame_Insnovelc.738_739insGAAp.Glu250dupp.E250dupA1Z1Q3protein_codingTCGA-Q1-A73P-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
MACROD2SNVMissense_Mutationc.559N>Gp.Thr187Alap.T187AA1Z1Q3protein_codingdeleterious(0)benign(0.385)TCGA-AA-3510-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
MACROD2SNVMissense_Mutationc.49N>Tp.Arg17Cysp.R17CA1Z1Q3protein_codingdeleterious(0)benign(0.042)TCGA-AA-3864-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownSD
MACROD2SNVMissense_Mutationc.97G>Tp.Asp33Tyrp.D33YA1Z1Q3protein_codingdeleterious(0)probably_damaging(0.953)TCGA-AA-A010-01Colorectumcolon adenocarcinomaFemale<65I/IIChemotherapyfolinicCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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