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Gene: MACO1 |
Gene summary for MACO1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MACO1 | Gene ID | 55219 |
| Gene name | macoilin 1 | |
| Gene Alias | MACOILIN | |
| Cytomap | 1p36.11 | |
| Gene Type | protein-coding | GO ID | GO:0006935 | UniProtAcc | Q8N5G2 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 55219 | MACO1 | NAFLD1 | Human | Liver | NAFLD | 1.50e-11 | 8.81e-01 | -0.04 |
| 55219 | MACO1 | HCC1_Meng | Human | Liver | HCC | 4.33e-03 | -9.79e-02 | 0.0246 |
| 55219 | MACO1 | HCC2_Meng | Human | Liver | HCC | 9.14e-03 | -9.79e-02 | 0.0107 |
| 55219 | MACO1 | cirrhotic1 | Human | Liver | Cirrhotic | 9.14e-03 | -9.79e-02 | 0.0202 |
| 55219 | MACO1 | cirrhotic2 | Human | Liver | Cirrhotic | 9.14e-03 | -9.79e-02 | 0.0201 |
| 55219 | MACO1 | Pt13.a | Human | Liver | HCC | 4.33e-03 | -9.79e-02 | 0.021 |
| 55219 | MACO1 | Pt14.d | Human | Liver | HCC | 4.33e-03 | -9.79e-02 | 0.0143 |
| 55219 | MACO1 | S014 | Human | Liver | HCC | 7.89e-11 | 5.48e-01 | 0.2254 |
| 55219 | MACO1 | S015 | Human | Liver | HCC | 1.28e-11 | 5.87e-01 | 0.2375 |
| 55219 | MACO1 | S016 | Human | Liver | HCC | 1.61e-18 | 7.20e-01 | 0.2243 |
| 55219 | MACO1 | S027 | Human | Liver | HCC | 1.05e-14 | 9.40e-01 | 0.2446 |
| 55219 | MACO1 | S028 | Human | Liver | HCC | 4.19e-32 | 1.16e+00 | 0.2503 |
| 55219 | MACO1 | S029 | Human | Liver | HCC | 2.40e-29 | 1.19e+00 | 0.2581 |
| 55219 | MACO1 | RNA-P17T-P17T-2 | Human | Lung | IAC | 1.99e-06 | 6.78e-01 | 0.3371 |
| 55219 | MACO1 | RNA-P17T-P17T-4 | Human | Lung | IAC | 4.28e-05 | 5.18e-01 | 0.343 |
| 55219 | MACO1 | RNA-P17T-P17T-6 | Human | Lung | IAC | 4.71e-02 | 4.95e-01 | 0.3385 |
| 55219 | MACO1 | RNA-P17T-P17T-8 | Human | Lung | IAC | 1.77e-07 | 6.02e-01 | 0.3329 |
| 55219 | MACO1 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 1.64e-08 | 4.33e-01 | -0.2116 |
| 55219 | MACO1 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 9.39e-09 | 6.97e-01 | -0.1941 |
| 55219 | MACO1 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.10e-04 | 3.60e-01 | -0.2119 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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