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Gene: LZTFL1 |
Gene summary for LZTFL1 |
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Gene information | Species | Human | Gene symbol | LZTFL1 | Gene ID | 54585 |
Gene name | leucine zipper transcription factor like 1 | |
Gene Alias | BBS17 | |
Cytomap | 3p21.31 | |
Gene Type | protein-coding | GO ID | GO:0008104 | UniProtAcc | Q9NQ48 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54585 | LZTFL1 | LZE24T | Human | Esophagus | ESCC | 4.63e-13 | 2.05e-01 | 0.0596 |
54585 | LZTFL1 | P1T-E | Human | Esophagus | ESCC | 5.74e-08 | 1.79e-01 | 0.0875 |
54585 | LZTFL1 | P2T-E | Human | Esophagus | ESCC | 1.69e-16 | 2.07e-01 | 0.1177 |
54585 | LZTFL1 | P4T-E | Human | Esophagus | ESCC | 1.86e-10 | 3.01e-01 | 0.1323 |
54585 | LZTFL1 | P5T-E | Human | Esophagus | ESCC | 3.99e-05 | 4.01e-02 | 0.1327 |
54585 | LZTFL1 | P8T-E | Human | Esophagus | ESCC | 2.09e-08 | 1.56e-01 | 0.0889 |
54585 | LZTFL1 | P9T-E | Human | Esophagus | ESCC | 6.73e-09 | 4.86e-02 | 0.1131 |
54585 | LZTFL1 | P10T-E | Human | Esophagus | ESCC | 1.17e-18 | 2.66e-01 | 0.116 |
54585 | LZTFL1 | P11T-E | Human | Esophagus | ESCC | 4.45e-03 | 9.75e-02 | 0.1426 |
54585 | LZTFL1 | P12T-E | Human | Esophagus | ESCC | 4.36e-11 | 2.21e-01 | 0.1122 |
54585 | LZTFL1 | P15T-E | Human | Esophagus | ESCC | 4.43e-13 | 2.09e-01 | 0.1149 |
54585 | LZTFL1 | P16T-E | Human | Esophagus | ESCC | 5.27e-20 | 3.37e-01 | 0.1153 |
54585 | LZTFL1 | P19T-E | Human | Esophagus | ESCC | 1.87e-04 | 3.54e-01 | 0.1662 |
54585 | LZTFL1 | P20T-E | Human | Esophagus | ESCC | 1.51e-10 | 8.52e-02 | 0.1124 |
54585 | LZTFL1 | P21T-E | Human | Esophagus | ESCC | 2.68e-19 | 3.23e-01 | 0.1617 |
54585 | LZTFL1 | P22T-E | Human | Esophagus | ESCC | 2.61e-14 | 2.15e-01 | 0.1236 |
54585 | LZTFL1 | P23T-E | Human | Esophagus | ESCC | 6.77e-15 | 2.95e-01 | 0.108 |
54585 | LZTFL1 | P24T-E | Human | Esophagus | ESCC | 1.64e-11 | 2.61e-01 | 0.1287 |
54585 | LZTFL1 | P26T-E | Human | Esophagus | ESCC | 5.86e-13 | 2.19e-01 | 0.1276 |
54585 | LZTFL1 | P27T-E | Human | Esophagus | ESCC | 1.46e-17 | 2.48e-01 | 0.1055 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:190547519 | Esophagus | ESCC | regulation of protein localization to membrane | 117/8552 | 175/18723 | 1.14e-08 | 2.26e-07 | 117 |
GO:190437519 | Esophagus | ESCC | regulation of protein localization to cell periphery | 85/8552 | 125/18723 | 3.63e-07 | 5.06e-06 | 85 |
GO:19038289 | Esophagus | ESCC | negative regulation of cellular protein localization | 76/8552 | 117/18723 | 1.97e-05 | 1.72e-04 | 76 |
GO:19043765 | Esophagus | ESCC | negative regulation of protein localization to cell periphery | 18/8552 | 26/18723 | 1.32e-02 | 4.31e-02 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LZTFL1 | SNV | Missense_Mutation | c.562N>C | p.Ala188Pro | p.A188P | Q9NQ48 | protein_coding | tolerated(0.22) | benign(0.165) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
LZTFL1 | SNV | Missense_Mutation | c.713N>C | p.Glu238Ala | p.E238A | Q9NQ48 | protein_coding | tolerated(0.41) | benign(0.017) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LZTFL1 | SNV | Missense_Mutation | novel | c.328N>G | p.Leu110Val | p.L110V | Q9NQ48 | protein_coding | deleterious(0.01) | possibly_damaging(0.895) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
LZTFL1 | SNV | Missense_Mutation | rs759640480 | c.55C>T | p.Arg19Cys | p.R19C | Q9NQ48 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LZTFL1 | deletion | Frame_Shift_Del | novel | c.91delA | p.Thr31LeufsTer2 | p.T31Lfs*2 | Q9NQ48 | protein_coding | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LZTFL1 | SNV | Missense_Mutation | novel | c.235N>G | p.Thr79Ala | p.T79A | Q9NQ48 | protein_coding | tolerated(0.07) | possibly_damaging(0.833) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LZTFL1 | SNV | Missense_Mutation | c.516A>T | p.Glu172Asp | p.E172D | Q9NQ48 | protein_coding | deleterious(0.04) | possibly_damaging(0.821) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
LZTFL1 | SNV | Missense_Mutation | novel | c.718N>A | p.Leu240Met | p.L240M | Q9NQ48 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LZTFL1 | SNV | Missense_Mutation | novel | c.556N>A | p.Glu186Lys | p.E186K | Q9NQ48 | protein_coding | tolerated(0.37) | benign(0.017) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
LZTFL1 | SNV | Missense_Mutation | novel | c.859N>C | p.Asp287His | p.D287H | Q9NQ48 | protein_coding | deleterious(0.01) | possibly_damaging(0.798) | TCGA-AX-A2H4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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