Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: LUZP1

Gene summary for LUZP1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

LUZP1

Gene ID

7798

Gene nameleucine zipper protein 1
Gene AliasLUZP
Cytomap1p36.12
Gene Typeprotein-coding
GO ID

GO:0001568

UniProtAcc

Q86V48


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7798LUZP1CA_HPV_1HumanCervixCC7.34e-03-1.30e-010.0264
7798LUZP1CA_HPV_2HumanCervixCC3.30e-022.70e-010.0391
7798LUZP1CA_HPV_3HumanCervixCC2.31e-042.17e-010.0414
7798LUZP1CCI_1HumanCervixCC2.60e-026.17e-010.528
7798LUZP1CCI_3HumanCervixCC1.66e-046.33e-010.516
7798LUZP1sample1HumanCervixCC1.84e-075.45e-010.0959
7798LUZP1T1HumanCervixCC1.02e-196.78e-010.0918
7798LUZP1HTA11_3410_2000001011HumanColorectumAD6.61e-05-3.35e-010.0155
7798LUZP1HTA11_866_3004761011HumanColorectumAD5.23e-03-3.22e-010.096
7798LUZP1HTA11_6818_2000001021HumanColorectumAD4.61e-02-3.64e-010.0588
7798LUZP1HTA11_99999970781_79442HumanColorectumMSS9.92e-05-3.39e-010.294
7798LUZP1HTA11_99999974143_84620HumanColorectumMSS3.42e-06-3.23e-010.3005
7798LUZP1A015-C-203HumanColorectumFAP1.92e-18-1.96e-01-0.1294
7798LUZP1A015-C-204HumanColorectumFAP4.20e-02-2.34e-02-0.0228
7798LUZP1A014-C-040HumanColorectumFAP2.73e-02-2.78e-01-0.1184
7798LUZP1A002-C-201HumanColorectumFAP2.15e-09-1.37e-010.0324
7798LUZP1A001-C-119HumanColorectumFAP1.27e-03-1.81e-01-0.1557
7798LUZP1A001-C-108HumanColorectumFAP2.73e-10-5.53e-03-0.0272
7798LUZP1A002-C-205HumanColorectumFAP1.64e-15-1.30e-01-0.1236
7798LUZP1A015-C-005HumanColorectumFAP1.85e-03-2.70e-01-0.0336
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00351487CervixCCtube formation31/2311148/187232.07e-031.51e-0231
GO:00018417CervixCCneural tube formation23/2311102/187232.80e-031.87e-0223
GO:00605626CervixCCepithelial tube morphogenesis57/2311325/187233.79e-032.41e-0257
GO:00140206CervixCCprimary neural tube formation21/231194/187234.68e-032.82e-0221
GO:00219156CervixCCneural tube development30/2311152/187236.00e-033.43e-0230
GO:0060562ColorectumADepithelial tube morphogenesis93/3918325/187235.65e-046.00e-0393
GO:0014020ColorectumADprimary neural tube formation33/391894/187231.02e-039.50e-0333
GO:0001841ColorectumADneural tube formation35/3918102/187231.16e-031.05e-0235
GO:0035148ColorectumADtube formation45/3918148/187234.13e-032.87e-0245
GO:0001838ColorectumADembryonic epithelial tube formation38/3918121/187234.40e-033.01e-0238
GO:0072175ColorectumADepithelial tube formation40/3918132/187236.98e-034.29e-0240
GO:0021915ColorectumADneural tube development45/3918152/187237.05e-034.31e-0245
GO:00605621ColorectumMSSepithelial tube morphogenesis88/3467325/187238.45e-051.37e-0388
GO:00140201ColorectumMSSprimary neural tube formation32/346794/187232.42e-043.30e-0332
GO:00018412ColorectumMSSneural tube formation34/3467102/187232.48e-043.37e-0334
GO:00351481ColorectumMSStube formation44/3467148/187236.06e-046.68e-0344
GO:00018381ColorectumMSSembryonic epithelial tube formation37/3467121/187238.95e-049.13e-0337
GO:00219151ColorectumMSSneural tube development43/3467152/187232.05e-031.75e-0243
GO:00721751ColorectumMSSepithelial tube formation38/3467132/187232.59e-032.05e-0238
GO:00605622ColorectumFAPepithelial tube morphogenesis71/2622325/187237.23e-051.33e-0371
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
LUZP1PVABreastADJTMEM70,CLIC1,ETS2, etc.2.57e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
LUZP1CD4TNSkinHealthyZNF219,PHF21A,SLC16A5, etc.3.05e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
LUZP1MVAThyroidATCTMEM44,AFDN,TMEM173, etc.3.80e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
LUZP1LYMENDThyroidHealthyTMEM44,AFDN,TMEM173, etc.7.48e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
LUZP1MVAThyroidHTTMEM44,AFDN,TMEM173, etc.4.08e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
LUZP1SNVMissense_Mutationc.2790G>Tp.Leu930Phep.L930FQ86V48protein_codingtolerated(0.06)possibly_damaging(0.839)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
LUZP1SNVMissense_Mutationrs560811130c.269G>Ap.Arg90Hisp.R90HQ86V48protein_codingtolerated(0.17)benign(0.003)TCGA-BH-A0HK-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
LUZP1SNVMissense_Mutationc.2128N>Ap.Asp710Asnp.D710NQ86V48protein_codingtolerated(1)benign(0.003)TCGA-BH-A18P-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownPD
LUZP1SNVMissense_Mutationnovelc.1834C>Ap.Gln612Lysp.Q612KQ86V48protein_codingdeleterious(0.01)possibly_damaging(0.84)TCGA-C8-A1HK-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
LUZP1SNVMissense_Mutationc.840N>Gp.Asn280Lysp.N280KQ86V48protein_codingdeleterious(0.02)probably_damaging(0.998)TCGA-D8-A13Z-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicineSD
LUZP1insertionIn_Frame_Insnovelc.74_75insGTTTAAGCTACAGAGTCTAAGCCGp.Phe18_Arg25dupp.F18_R25dupQ86V48protein_codingTCGA-A2-A0T5-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificTaxotereSD
LUZP1insertionFrame_Shift_Insnovelc.2141_2142insCTp.Glu714AspfsTer2p.E714Dfs*2Q86V48protein_codingTCGA-AN-A03Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
LUZP1insertionIn_Frame_Insnovelc.2140_2141insCCTGTGTGACCCAGGATCTTGAGAp.Glu714delinsAlaCysValThrGlnAspLeuGluLysp.E714delinsACVTQDLEKQ86V48protein_codingTCGA-AN-A03Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
LUZP1insertionFrame_Shift_Insnovelc.2665_2666insAATCTGTCTTCTCTTCCCTTGGTTTGCCAGAGCAGCTAAAGp.Arg889LysfsTer56p.R889Kfs*56Q86V48protein_codingTCGA-AO-A03O-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydoxorubicinSD
LUZP1insertionIn_Frame_Insnovelc.2754_2755insGCCAGAGCAGCTAAAGGAGCTCCCCGTAGGp.Val918_Thr919insAlaArgAlaAlaLysGlyAlaProArgArgp.V918_T919insARAAKGAPRRQ86V48protein_codingTCGA-BH-A0B8-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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