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Gene: LSS |
Gene summary for LSS |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LSS | Gene ID | 4047 |
| Gene name | lanosterol synthase | |
| Gene Alias | APMR4 | |
| Cytomap | 21q22.3 | |
| Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | B2R694 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 4047 | LSS | LZE24T | Human | Esophagus | ESCC | 9.82e-07 | 2.76e-01 | 0.0596 |
| 4047 | LSS | P2T-E | Human | Esophagus | ESCC | 1.02e-09 | 1.23e-01 | 0.1177 |
| 4047 | LSS | P4T-E | Human | Esophagus | ESCC | 5.69e-08 | 2.74e-01 | 0.1323 |
| 4047 | LSS | P5T-E | Human | Esophagus | ESCC | 1.08e-16 | 4.35e-02 | 0.1327 |
| 4047 | LSS | P8T-E | Human | Esophagus | ESCC | 7.81e-04 | 5.95e-02 | 0.0889 |
| 4047 | LSS | P9T-E | Human | Esophagus | ESCC | 6.56e-03 | 6.86e-02 | 0.1131 |
| 4047 | LSS | P10T-E | Human | Esophagus | ESCC | 3.93e-28 | 6.49e-01 | 0.116 |
| 4047 | LSS | P11T-E | Human | Esophagus | ESCC | 6.99e-04 | 1.48e-01 | 0.1426 |
| 4047 | LSS | P12T-E | Human | Esophagus | ESCC | 2.17e-09 | 1.63e-01 | 0.1122 |
| 4047 | LSS | P15T-E | Human | Esophagus | ESCC | 2.54e-03 | 3.90e-02 | 0.1149 |
| 4047 | LSS | P16T-E | Human | Esophagus | ESCC | 1.05e-11 | 1.76e-01 | 0.1153 |
| 4047 | LSS | P20T-E | Human | Esophagus | ESCC | 6.41e-05 | 3.48e-02 | 0.1124 |
| 4047 | LSS | P21T-E | Human | Esophagus | ESCC | 2.35e-16 | 2.57e-01 | 0.1617 |
| 4047 | LSS | P22T-E | Human | Esophagus | ESCC | 2.51e-09 | 1.34e-01 | 0.1236 |
| 4047 | LSS | P24T-E | Human | Esophagus | ESCC | 6.61e-09 | 4.58e-02 | 0.1287 |
| 4047 | LSS | P26T-E | Human | Esophagus | ESCC | 8.69e-14 | 1.08e-01 | 0.1276 |
| 4047 | LSS | P27T-E | Human | Esophagus | ESCC | 1.93e-16 | 1.42e-01 | 0.1055 |
| 4047 | LSS | P28T-E | Human | Esophagus | ESCC | 1.83e-16 | 4.02e-01 | 0.1149 |
| 4047 | LSS | P30T-E | Human | Esophagus | ESCC | 3.25e-15 | 4.88e-01 | 0.137 |
| 4047 | LSS | P31T-E | Human | Esophagus | ESCC | 2.96e-11 | 8.09e-02 | 0.1251 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0031647111 | Esophagus | ESCC | regulation of protein stability | 223/8552 | 298/18723 | 5.76e-25 | 1.52e-22 | 223 |
| GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
| GO:00161263 | Esophagus | ESCC | sterol biosynthetic process | 46/8552 | 64/18723 | 1.91e-05 | 1.67e-04 | 46 |
| GO:00066953 | Esophagus | ESCC | cholesterol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
| GO:19026533 | Esophagus | ESCC | secondary alcohol biosynthetic process | 41/8552 | 57/18723 | 5.25e-05 | 4.06e-04 | 41 |
| GO:19026524 | Esophagus | ESCC | secondary alcohol metabolic process | 87/8552 | 147/18723 | 6.58e-04 | 3.50e-03 | 87 |
| GO:00461653 | Esophagus | ESCC | alcohol biosynthetic process | 83/8552 | 140/18723 | 8.04e-04 | 4.16e-03 | 83 |
| GO:00082991 | Esophagus | ESCC | isoprenoid biosynthetic process | 21/8552 | 28/18723 | 1.57e-03 | 7.33e-03 | 21 |
| GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
| GO:00082034 | Esophagus | ESCC | cholesterol metabolic process | 79/8552 | 137/18723 | 3.11e-03 | 1.29e-02 | 79 |
| GO:00161254 | Esophagus | ESCC | sterol metabolic process | 86/8552 | 152/18723 | 4.37e-03 | 1.73e-02 | 86 |
| GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
| GO:003164722 | Liver | HCC | regulation of protein stability | 211/7958 | 298/18723 | 2.29e-23 | 5.01e-21 | 211 |
| GO:000606621 | Liver | HCC | alcohol metabolic process | 208/7958 | 353/18723 | 2.80e-10 | 9.50e-09 | 208 |
| GO:19026522 | Liver | HCC | secondary alcohol metabolic process | 100/7958 | 147/18723 | 3.26e-10 | 1.09e-08 | 100 |
| GO:00082032 | Liver | HCC | cholesterol metabolic process | 94/7958 | 137/18723 | 5.39e-10 | 1.72e-08 | 94 |
| GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
| GO:00161252 | Liver | HCC | sterol metabolic process | 101/7958 | 152/18723 | 1.99e-09 | 5.63e-08 | 101 |
| GO:00066951 | Liver | HCC | cholesterol biosynthetic process | 43/7958 | 57/18723 | 4.37e-07 | 7.23e-06 | 43 |
| GO:19026531 | Liver | HCC | secondary alcohol biosynthetic process | 43/7958 | 57/18723 | 4.37e-07 | 7.23e-06 | 43 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa001005 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
| hsa0010012 | Esophagus | ESCC | Steroid biosynthesis | 18/4205 | 20/8465 | 1.78e-04 | 6.79e-04 | 3.48e-04 | 18 |
| hsa001002 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
| hsa001003 | Liver | HCC | Steroid biosynthesis | 15/4020 | 20/8465 | 1.17e-02 | 2.97e-02 | 1.65e-02 | 15 |
| hsa001004 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
| hsa0010011 | Oral cavity | OSCC | Steroid biosynthesis | 15/3704 | 20/8465 | 4.62e-03 | 1.13e-02 | 5.75e-03 | 15 |
| hsa0010021 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
| hsa0010031 | Oral cavity | LP | Steroid biosynthesis | 11/2418 | 20/8465 | 1.16e-02 | 3.91e-02 | 2.52e-02 | 11 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| LSS | SNV | Missense_Mutation | rs561449819 | c.1762N>A | p.Gly588Ser | p.G588S | P48449 | protein_coding | deleterious(0.01) | probably_damaging(0.973) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| LSS | SNV | Missense_Mutation | c.214A>C | p.Thr72Pro | p.T72P | P48449 | protein_coding | deleterious(0.01) | possibly_damaging(0.805) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| LSS | SNV | Missense_Mutation | c.999N>G | p.Ile333Met | p.I333M | P48449 | protein_coding | tolerated(0.17) | probably_damaging(0.942) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| LSS | SNV | Missense_Mutation | c.749N>T | p.Ala250Val | p.A250V | P48449 | protein_coding | tolerated(0.2) | possibly_damaging(0.644) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
| LSS | SNV | Missense_Mutation | rs762530682 | c.1168N>A | p.Ala390Thr | p.A390T | P48449 | protein_coding | deleterious(0.05) | possibly_damaging(0.596) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
| LSS | SNV | Missense_Mutation | rs200708561 | c.386N>A | p.Arg129Gln | p.R129Q | P48449 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
| LSS | SNV | Missense_Mutation | c.1317N>T | p.Lys439Asn | p.K439N | P48449 | protein_coding | deleterious(0) | possibly_damaging(0.866) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| LSS | SNV | Missense_Mutation | c.841N>A | p.Ala281Thr | p.A281T | P48449 | protein_coding | deleterious(0.02) | possibly_damaging(0.581) | TCGA-AD-6901-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
| LSS | SNV | Missense_Mutation | rs375698498 | c.1348G>A | p.Gly450Ser | p.G450S | P48449 | protein_coding | tolerated(0.05) | probably_damaging(1) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| LSS | SNV | Missense_Mutation | novel | c.642N>T | p.Glu214Asp | p.E214D | P48449 | protein_coding | deleterious(0) | possibly_damaging(0.858) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103329 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103323 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103320 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103325 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103321 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103333 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103324 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103327 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103326 | ||
| 4047 | LSS | ENZYME, DRUGGABLE GENOME | inhibitor | 178103322 |
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