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Gene: LRRC74B |
Gene summary for LRRC74B |
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Gene information | Species | Human | Gene symbol | LRRC74B | Gene ID | 400891 |
Gene name | leucine rich repeat containing 74B | |
Gene Alias | LRRC74B | |
Cytomap | 22q11.21 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q6ZQY2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
400891 | LRRC74B | HCC1 | Human | Liver | HCC | 1.33e-09 | 9.29e-01 | 0.5336 |
400891 | LRRC74B | HCC2 | Human | Liver | HCC | 1.54e-19 | 1.49e+00 | 0.5341 |
400891 | LRRC74B | HCC5 | Human | Liver | HCC | 2.91e-30 | 1.42e+00 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC74B | SNV | Missense_Mutation | rs369394331 | c.496N>T | p.Arg166Trp | p.R166W | Q6ZQY2 | protein_coding | tolerated(0.18) | benign(0.001) | TCGA-AR-A5QQ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD |
LRRC74B | SNV | Missense_Mutation | c.688N>T | p.His230Tyr | p.H230Y | Q6ZQY2 | protein_coding | tolerated(0.05) | benign(0.324) | TCGA-C5-A1BQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
LRRC74B | SNV | Missense_Mutation | rs12170538 | c.7G>C | p.Gly3Arg | p.G3R | Q6ZQY2 | protein_coding | tolerated_low_confidence(0.05) | benign(0.119) | TCGA-C5-A3HE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
LRRC74B | SNV | Missense_Mutation | c.797N>T | p.Ala266Val | p.A266V | Q6ZQY2 | protein_coding | deleterious(0.03) | benign(0.154) | TCGA-AA-3502-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRRC74B | SNV | Missense_Mutation | c.1073N>T | p.Gly358Val | p.G358V | Q6ZQY2 | protein_coding | tolerated(0.63) | benign(0) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRRC74B | SNV | Missense_Mutation | novel | c.865N>A | p.Ala289Thr | p.A289T | Q6ZQY2 | protein_coding | tolerated(0.41) | benign(0.119) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC74B | SNV | Missense_Mutation | novel | c.574G>T | p.Asp192Tyr | p.D192Y | Q6ZQY2 | protein_coding | tolerated(0.1) | possibly_damaging(0.611) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC74B | SNV | Missense_Mutation | rs199701252 | c.428C>T | p.Ser143Leu | p.S143L | Q6ZQY2 | protein_coding | deleterious(0) | benign(0.213) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRRC74B | SNV | Missense_Mutation | c.310N>G | p.Ser104Gly | p.S104G | Q6ZQY2 | protein_coding | deleterious(0.01) | benign(0.155) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LRRC74B | SNV | Missense_Mutation | novel | c.472G>A | p.Ala158Thr | p.A158T | Q6ZQY2 | protein_coding | tolerated(0.23) | benign(0.07) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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