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Gene: LRRC36 |
Gene summary for LRRC36 |
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Gene information | Species | Human | Gene symbol | LRRC36 | Gene ID | 55282 |
Gene name | leucine rich repeat containing 36 | |
Gene Alias | RORBP70 | |
Cytomap | 16q22.1 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | B7Z4G3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55282 | LRRC36 | RNA-P25T1-P25T1-1 | Human | Lung | AIS | 6.42e-11 | 5.52e-01 | -0.2116 |
55282 | LRRC36 | RNA-P25T1-P25T1-2 | Human | Lung | AIS | 8.63e-05 | 5.12e-01 | -0.1941 |
55282 | LRRC36 | RNA-P25T1-P25T1-3 | Human | Lung | AIS | 8.24e-06 | 6.43e-01 | -0.2107 |
55282 | LRRC36 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 1.22e-14 | 7.04e-01 | -0.2119 |
55282 | LRRC36 | HTA12-23-1 | Human | Pancreas | PDAC | 8.01e-05 | 6.96e-01 | 0.3405 |
55282 | LRRC36 | HTA12-26-1 | Human | Pancreas | PDAC | 2.87e-14 | 7.03e-01 | 0.3728 |
55282 | LRRC36 | HTA12-29-1 | Human | Pancreas | PDAC | 1.12e-42 | 9.04e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC36 | SNV | Missense_Mutation | c.2186N>A | p.Ser729Tyr | p.S729Y | Q1X8D7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.693) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LRRC36 | SNV | Missense_Mutation | c.1435N>A | p.Asp479Asn | p.D479N | Q1X8D7 | protein_coding | deleterious_low_confidence(0) | benign(0.424) | TCGA-D8-A1X5-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
LRRC36 | deletion | Frame_Shift_Del | novel | c.1690delG | p.Val564Ter | p.V564* | Q1X8D7 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
LRRC36 | SNV | Missense_Mutation | novel | c.601N>A | p.Pro201Thr | p.P201T | Q1X8D7 | protein_coding | tolerated_low_confidence(0.08) | possibly_damaging(0.461) | TCGA-EK-A2RO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC36 | SNV | Missense_Mutation | c.949N>G | p.Ser317Gly | p.S317G | Q1X8D7 | protein_coding | tolerated_low_confidence(0.06) | benign(0.003) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRRC36 | SNV | Missense_Mutation | c.995A>T | p.Asn332Ile | p.N332I | Q1X8D7 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.777) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRRC36 | SNV | Missense_Mutation | novel | c.1293N>G | p.His431Gln | p.H431Q | Q1X8D7 | protein_coding | tolerated_low_confidence(0.11) | benign(0.118) | TCGA-AA-A01C-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
LRRC36 | SNV | Missense_Mutation | c.1448C>T | p.Ala483Val | p.A483V | Q1X8D7 | protein_coding | deleterious_low_confidence(0.05) | possibly_damaging(0.71) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
LRRC36 | SNV | Missense_Mutation | rs771054996 | c.701N>G | p.Gln234Arg | p.Q234R | Q1X8D7 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
LRRC36 | SNV | Missense_Mutation | c.1963N>T | p.Met655Leu | p.M655L | Q1X8D7 | protein_coding | tolerated(0.65) | benign(0) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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