Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: LRP8

Gene summary for LRP8

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

LRP8

Gene ID

7804

Gene nameLDL receptor related protein 8
Gene AliasAPOER2
Cytomap1p32.3
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

Q14114


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
7804LRP8male-WTAHumanThyroidPTC1.54e-091.59e-010.1037
7804LRP8PTC01HumanThyroidPTC1.78e-081.93e-010.1899
7804LRP8PTC05HumanThyroidPTC2.62e-031.24e-010.2065
7804LRP8PTC06HumanThyroidPTC4.78e-501.36e+000.2057
7804LRP8PTC07HumanThyroidPTC3.09e-091.78e-010.2044
7804LRP8ATC09HumanThyroidATC3.60e-051.33e-010.2871
7804LRP8ATC1HumanThyroidATC7.65e-061.62e-010.2878
7804LRP8ATC2HumanThyroidATC4.15e-034.96e-010.34
7804LRP8ATC4HumanThyroidATC3.58e-038.30e-020.34
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0022604112ThyroidPTCregulation of cell morphogenesis165/5968309/187232.60e-151.82e-13165
GO:0031346110ThyroidPTCpositive regulation of cell projection organization173/5968353/187231.09e-114.40e-10173
GO:0045860111ThyroidPTCpositive regulation of protein kinase activity176/5968386/187238.89e-092.17e-07176
GO:006099616ThyroidPTCdendritic spine development59/596899/187231.18e-082.83e-0759
GO:0010769111ThyroidPTCregulation of cell morphogenesis involved in differentiation57/596896/187232.50e-085.62e-0757
GO:0010975110ThyroidPTCregulation of neuron projection development194/5968445/187231.05e-072.08e-06194
GO:001072018ThyroidPTCpositive regulation of cell development138/5968298/187231.13e-072.22e-06138
GO:0010770111ThyroidPTCpositive regulation of cell morphogenesis involved in differentiation48/596879/187231.15e-072.26e-0648
GO:0033674111ThyroidPTCpositive regulation of kinase activity201/5968467/187231.95e-073.54e-06201
GO:001635819ThyroidPTCdendrite development115/5968243/187233.16e-075.35e-06115
GO:005076914ThyroidPTCpositive regulation of neurogenesis105/5968225/187232.28e-063.05e-05105
GO:00609988ThyroidPTCregulation of dendritic spine development37/596861/187233.41e-064.40e-0537
GO:010602715ThyroidPTCneuron projection organization51/596893/187233.76e-064.75e-0551
GO:009706110ThyroidPTCdendritic spine organization47/596884/187234.27e-065.28e-0547
GO:005076716ThyroidPTCregulation of neurogenesis156/5968364/187235.86e-067.05e-05156
GO:00609994ThyroidPTCpositive regulation of dendritic spine development27/596842/187231.58e-051.67e-0427
GO:00610017ThyroidPTCregulation of dendritic spine morphogenesis29/596847/187232.44e-052.40e-0429
GO:00609976ThyroidPTCdendritic spine morphogenesis35/596861/187233.41e-053.22e-0435
GO:005196214ThyroidPTCpositive regulation of nervous system development117/5968272/187236.72e-055.89e-04117
GO:00488139ThyroidPTCdendrite morphogenesis69/5968146/187237.12e-056.19e-0469
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
LRP8SNVMissense_Mutationnovelc.2328N>Tp.Glu776Aspp.E776DQ14114protein_codingtolerated(0.22)benign(0.225)TCGA-5L-AAT1-01Breastbreast invasive carcinomaFemale<65III/IVHormone TherapyletrozolSD
LRP8SNVMissense_Mutationrs756453748c.2038G>Ap.Glu680Lysp.E680KQ14114protein_codingdeleterious(0.05)possibly_damaging(0.802)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
LRP8SNVMissense_Mutationc.1825N>Cp.Ser609Prop.S609PQ14114protein_codingdeleterious(0.01)probably_damaging(0.983)TCGA-AN-A0AT-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
LRP8SNVMissense_Mutationrs758211330c.1595N>Ap.Arg532Hisp.R532HQ14114protein_codingdeleterious(0.01)benign(0.015)TCGA-AQ-A0Y5-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycytoxanSD
LRP8SNVMissense_Mutationc.2322C>Gp.Ser774Argp.S774RQ14114protein_codingtolerated(0.11)benign(0.007)TCGA-AR-A24Q-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
LRP8SNVMissense_Mutationc.1094N>Cp.Gly365Alap.G365AQ14114protein_codingdeleterious(0.01)probably_damaging(1)TCGA-GM-A2DH-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxolCR
LRP8deletionFrame_Shift_Delnovelc.2261_2267delNNNNNNNp.Val754AlafsTer25p.V754Afs*25Q14114protein_codingTCGA-A8-A08H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
LRP8insertionNonsense_Mutationnovelc.2746_2747insTAGCATCTACCTAATGACTGGAp.Pro916LeufsTer5p.P916Lfs*5Q14114protein_codingTCGA-AN-A03X-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
LRP8insertionNonsense_Mutationnovelc.2397_2398insCTTACAAAGTGGAAATAACCACCCTTCCACAACp.Ser799_Thr800insLeuThrLysTrpLysTerProProPheHisAsnp.S799_T800insLTKWK*PPFHNQ14114protein_codingTCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
LRP8insertionFrame_Shift_Insnovelc.2556_2557insGACGGAAGGAp.Arg853AspfsTer13p.R853Dfs*13Q14114protein_codingTCGA-AR-A0TU-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificDoxorubicinSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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