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Gene: LRP11 |
Gene summary for LRP11 |
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Gene information | Species | Human | Gene symbol | LRP11 | Gene ID | 84918 |
Gene name | LDL receptor related protein 11 | |
Gene Alias | MANSC3 | |
Cytomap | 6q25.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | B4DS68 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84918 | LRP11 | LZE5T | Human | Esophagus | ESCC | 3.58e-08 | 5.52e-01 | 0.0514 |
84918 | LRP11 | LZE24T | Human | Esophagus | ESCC | 2.24e-10 | 5.12e-01 | 0.0596 |
84918 | LRP11 | LZE21T | Human | Esophagus | ESCC | 2.80e-02 | 3.54e-01 | 0.0655 |
84918 | LRP11 | P2T-E | Human | Esophagus | ESCC | 4.33e-03 | 5.65e-02 | 0.1177 |
84918 | LRP11 | P5T-E | Human | Esophagus | ESCC | 1.19e-13 | 1.70e-01 | 0.1327 |
84918 | LRP11 | P8T-E | Human | Esophagus | ESCC | 2.39e-20 | 3.90e-01 | 0.0889 |
84918 | LRP11 | P9T-E | Human | Esophagus | ESCC | 1.75e-05 | 2.01e-01 | 0.1131 |
84918 | LRP11 | P10T-E | Human | Esophagus | ESCC | 6.08e-14 | 2.47e-01 | 0.116 |
84918 | LRP11 | P11T-E | Human | Esophagus | ESCC | 5.68e-10 | 3.56e-01 | 0.1426 |
84918 | LRP11 | P12T-E | Human | Esophagus | ESCC | 3.47e-11 | 1.84e-01 | 0.1122 |
84918 | LRP11 | P15T-E | Human | Esophagus | ESCC | 1.15e-18 | 4.62e-01 | 0.1149 |
84918 | LRP11 | P16T-E | Human | Esophagus | ESCC | 1.32e-06 | 1.39e-01 | 0.1153 |
84918 | LRP11 | P17T-E | Human | Esophagus | ESCC | 7.25e-03 | 2.82e-01 | 0.1278 |
84918 | LRP11 | P20T-E | Human | Esophagus | ESCC | 2.46e-13 | 2.52e-01 | 0.1124 |
84918 | LRP11 | P21T-E | Human | Esophagus | ESCC | 7.32e-15 | 3.47e-01 | 0.1617 |
84918 | LRP11 | P22T-E | Human | Esophagus | ESCC | 4.00e-04 | 5.22e-02 | 0.1236 |
84918 | LRP11 | P23T-E | Human | Esophagus | ESCC | 2.20e-03 | 1.81e-01 | 0.108 |
84918 | LRP11 | P24T-E | Human | Esophagus | ESCC | 1.97e-02 | 5.93e-02 | 0.1287 |
84918 | LRP11 | P26T-E | Human | Esophagus | ESCC | 5.93e-06 | 7.12e-02 | 0.1276 |
84918 | LRP11 | P28T-E | Human | Esophagus | ESCC | 2.20e-17 | 3.22e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRP11 | SNV | Missense_Mutation | c.983C>A | p.Ala328Asp | p.A328D | Q86VZ4 | protein_coding | deleterious(0.01) | probably_damaging(0.988) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
LRP11 | deletion | Frame_Shift_Del | novel | c.796delN | p.Leu266CysfsTer13 | p.L266Cfs*13 | Q86VZ4 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
LRP11 | SNV | Missense_Mutation | c.926N>T | p.Thr309Ile | p.T309I | Q86VZ4 | protein_coding | tolerated(0.27) | benign(0.005) | TCGA-C5-A1MF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LRP11 | SNV | Missense_Mutation | c.1056N>C | p.Lys352Asn | p.K352N | Q86VZ4 | protein_coding | deleterious(0.03) | probably_damaging(0.917) | TCGA-DS-A0VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LRP11 | SNV | Missense_Mutation | rs374603588 | c.895N>A | p.Ala299Thr | p.A299T | Q86VZ4 | protein_coding | tolerated(0.61) | benign(0.001) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LRP11 | SNV | Missense_Mutation | c.737N>T | p.Ala246Val | p.A246V | Q86VZ4 | protein_coding | deleterious(0.04) | benign(0.079) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LRP11 | SNV | Missense_Mutation | c.1084N>T | p.Ala362Ser | p.A362S | Q86VZ4 | protein_coding | tolerated(0.47) | benign(0.036) | TCGA-NH-A8F8-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
LRP11 | SNV | Missense_Mutation | novel | c.946N>G | p.Phe316Val | p.F316V | Q86VZ4 | protein_coding | tolerated(0.61) | possibly_damaging(0.625) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LRP11 | SNV | Missense_Mutation | c.839T>C | p.Val280Ala | p.V280A | Q86VZ4 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
LRP11 | SNV | Missense_Mutation | rs768949248 | c.1450N>T | p.Arg484Cys | p.R484C | Q86VZ4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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