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Gene: LRP10 |
Gene summary for LRP10 |
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Gene information | Species | Human | Gene symbol | LRP10 | Gene ID | 26020 |
Gene name | LDL receptor related protein 10 | |
Gene Alias | LRP-10 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | Q7Z4F1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26020 | LRP10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.01e-31 | 1.31e+00 | -0.1808 |
26020 | LRP10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.82e-13 | 6.56e-01 | -0.0811 |
26020 | LRP10 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.50e-14 | 6.09e-01 | -0.1088 |
26020 | LRP10 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.73e-30 | 7.22e-01 | -0.1954 |
26020 | LRP10 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.85e-12 | 2.14e+00 | -0.2602 |
26020 | LRP10 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.47e-13 | 1.37e+00 | -0.2196 |
26020 | LRP10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.13e-10 | 6.19e-01 | -0.1207 |
26020 | LRP10 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.47e-10 | 5.73e-01 | -0.1526 |
26020 | LRP10 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.94e-26 | 8.21e-01 | -0.1464 |
26020 | LRP10 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.12e-09 | 4.64e-01 | -0.1001 |
26020 | LRP10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.89e-30 | 9.46e-01 | -0.059 |
26020 | LRP10 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.94e-07 | 7.34e-01 | -0.1706 |
26020 | LRP10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.66e-06 | 7.46e-01 | -0.2061 |
26020 | LRP10 | HTA11_5216_2000001011 | Human | Colorectum | SER | 4.15e-02 | 7.13e-01 | -0.1462 |
26020 | LRP10 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.78e-03 | 4.65e-01 | -0.0842 |
26020 | LRP10 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.55e-03 | 2.34e-01 | 0.096 |
26020 | LRP10 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.30e-04 | 3.77e-01 | 0.0446 |
26020 | LRP10 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.47e-03 | 3.60e-01 | 0.0131 |
26020 | LRP10 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.90e-02 | 5.03e-01 | -0.0177 |
26020 | LRP10 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.32e-05 | 6.41e-01 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
GO:001087611 | Liver | Cirrhotic | lipid localization | 147/4634 | 448/18723 | 6.24e-05 | 7.12e-04 | 147 |
GO:000686911 | Liver | Cirrhotic | lipid transport | 128/4634 | 398/18723 | 4.54e-04 | 3.69e-03 | 128 |
GO:001087621 | Liver | HCC | lipid localization | 228/7958 | 448/18723 | 1.80e-04 | 1.41e-03 | 228 |
GO:000686921 | Liver | HCC | lipid transport | 198/7958 | 398/18723 | 1.92e-03 | 9.78e-03 | 198 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRP10 | insertion | In_Frame_Ins | novel | c.355_356insATTGCATGTCCTGCCTGAGATTCAGAACTA | p.Ala119delinsAspCysMetSerCysLeuArgPheArgThrThr | p.A119delinsDCMSCLRFRTT | Q7Z4F1 | protein_coding | TCGA-A8-A09K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRP10 | insertion | Frame_Shift_Ins | novel | c.1438dupC | p.Leu480ProfsTer7 | p.L480Pfs*7 | Q7Z4F1 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
LRP10 | SNV | Missense_Mutation | novel | c.152N>A | p.Arg51His | p.R51H | Q7Z4F1 | protein_coding | tolerated(0.31) | benign(0.003) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LRP10 | SNV | Missense_Mutation | rs143157984 | c.887N>A | p.Arg296His | p.R296H | Q7Z4F1 | protein_coding | tolerated(0.16) | possibly_damaging(0.757) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LRP10 | SNV | Missense_Mutation | novel | c.1718N>T | p.Ala573Val | p.A573V | Q7Z4F1 | protein_coding | tolerated(0.1) | benign(0.037) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LRP10 | SNV | Missense_Mutation | c.208A>G | p.Thr70Ala | p.T70A | Q7Z4F1 | protein_coding | deleterious(0.01) | benign(0.193) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LRP10 | SNV | Missense_Mutation | rs373629359 | c.913N>T | p.Arg305Trp | p.R305W | Q7Z4F1 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
LRP10 | SNV | Missense_Mutation | rs760967418 | c.1577N>A | p.Arg526His | p.R526H | Q7Z4F1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LRP10 | SNV | Missense_Mutation | c.1784G>A | p.Gly595Asp | p.G595D | Q7Z4F1 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRP10 | SNV | Missense_Mutation | rs375804347 | c.1576N>T | p.Arg526Cys | p.R526C | Q7Z4F1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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