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Gene: LIX1 |
Gene summary for LIX1 |
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Gene information | Species | Human | Gene symbol | LIX1 | Gene ID | 167410 |
Gene name | limb and CNS expressed 1 | |
Gene Alias | C5orf11 | |
Cytomap | 5q15 | |
Gene Type | protein-coding | GO ID | GO:0006914 | UniProtAcc | Q8N485 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
167410 | LIX1 | S014 | Human | Liver | HCC | 1.39e-31 | 8.46e-01 | 0.2254 |
167410 | LIX1 | S015 | Human | Liver | HCC | 4.50e-13 | 6.31e-01 | 0.2375 |
167410 | LIX1 | S016 | Human | Liver | HCC | 5.38e-24 | 6.95e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001623617 | Esophagus | ESCC | macroautophagy | 216/8552 | 291/18723 | 1.94e-23 | 4.57e-21 | 216 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:00973523 | Esophagus | ESCC | autophagosome maturation | 31/8552 | 40/18723 | 4.04e-05 | 3.26e-04 | 31 |
GO:001623621 | Liver | HCC | macroautophagy | 204/7958 | 291/18723 | 8.66e-22 | 1.41e-19 | 204 |
GO:002241112 | Liver | HCC | cellular component disassembly | 282/7958 | 443/18723 | 1.02e-19 | 1.38e-17 | 282 |
GO:003298411 | Liver | HCC | protein-containing complex disassembly | 138/7958 | 224/18723 | 5.59e-09 | 1.46e-07 | 138 |
GO:00973521 | Liver | HCC | autophagosome maturation | 30/7958 | 40/18723 | 3.04e-05 | 3.12e-04 | 30 |
GO:002241119 | Oral cavity | OSCC | cellular component disassembly | 283/7305 | 443/18723 | 9.57e-27 | 3.37e-24 | 283 |
GO:001623610 | Oral cavity | OSCC | macroautophagy | 192/7305 | 291/18723 | 7.01e-21 | 1.14e-18 | 192 |
GO:003298410 | Oral cavity | OSCC | protein-containing complex disassembly | 136/7305 | 224/18723 | 3.42e-11 | 1.13e-09 | 136 |
GO:00973522 | Oral cavity | OSCC | autophagosome maturation | 28/7305 | 40/18723 | 7.00e-05 | 5.60e-04 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIX1 | SNV | Missense_Mutation | c.676N>G | p.Arg226Gly | p.R226G | Q8N485 | protein_coding | tolerated(0.18) | benign(0.062) | TCGA-EW-A1P4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD | |
LIX1 | SNV | Missense_Mutation | novel | c.169G>C | p.Glu57Gln | p.E57Q | Q8N485 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LIX1 | SNV | Missense_Mutation | novel | c.79N>T | p.Asp27Tyr | p.D27Y | Q8N485 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LIX1 | SNV | Missense_Mutation | rs139105148 | c.538N>T | p.Arg180Cys | p.R180C | Q8N485 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
LIX1 | SNV | Missense_Mutation | c.172N>C | p.Ser58Pro | p.S58P | Q8N485 | protein_coding | tolerated(0.16) | possibly_damaging(0.855) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
LIX1 | SNV | Missense_Mutation | rs774112919 | c.416G>T | p.Ser139Ile | p.S139I | Q8N485 | protein_coding | deleterious(0.01) | possibly_damaging(0.648) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LIX1 | SNV | Missense_Mutation | c.182N>A | p.Ala61Asp | p.A61D | Q8N485 | protein_coding | deleterious(0.01) | benign(0.015) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LIX1 | SNV | Missense_Mutation | c.617N>C | p.Met206Thr | p.M206T | Q8N485 | protein_coding | deleterious(0) | benign(0.351) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LIX1 | SNV | Missense_Mutation | rs139105148 | c.538C>T | p.Arg180Cys | p.R180C | Q8N485 | protein_coding | deleterious(0) | probably_damaging(0.96) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LIX1 | SNV | Missense_Mutation | c.665N>T | p.Ser222Phe | p.S222F | Q8N485 | protein_coding | tolerated(0.31) | benign(0.431) | TCGA-EI-6510-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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