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Gene: LINC01605 |
Gene summary for LINC01605 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LINC01605 | Gene ID | 100507420 |
| Gene name | long intergenic non-protein coding RNA 1605 | |
| Gene Alias | LincDUSP | |
| Cytomap | 8p11.23 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 100507420 | LINC01605 | CCI_1 | Human | Cervix | CC | 3.21e-13 | 5.57e-01 | 0.528 |
| 100507420 | LINC01605 | CCI_3 | Human | Cervix | CC | 3.20e-10 | 5.47e-01 | 0.516 |
| 100507420 | LINC01605 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.72e-06 | -2.07e-01 | 0.0155 |
| 100507420 | LINC01605 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.06e-02 | -2.07e-01 | -0.1808 |
| 100507420 | LINC01605 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.26e-03 | -2.07e-01 | -0.1088 |
| 100507420 | LINC01605 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.10e-07 | -2.07e-01 | -0.1954 |
| 100507420 | LINC01605 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.47e-08 | -2.07e-01 | -0.1464 |
| 100507420 | LINC01605 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.07e-07 | -2.07e-01 | -0.1001 |
| 100507420 | LINC01605 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.27e-04 | -2.07e-01 | -0.059 |
| 100507420 | LINC01605 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.93e-05 | -2.07e-01 | 0.096 |
| 100507420 | LINC01605 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.43e-02 | -2.07e-01 | 0.0338 |
| 100507420 | LINC01605 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.07e-07 | -2.07e-01 | 0.0674 |
| 100507420 | LINC01605 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.92e-09 | 5.43e-01 | 0.294 |
| 100507420 | LINC01605 | A002-C-010 | Human | Colorectum | FAP | 3.00e-02 | 3.18e-01 | 0.242 |
| 100507420 | LINC01605 | A015-C-203 | Human | Colorectum | FAP | 1.64e-04 | 2.64e-01 | -0.1294 |
| 100507420 | LINC01605 | A002-C-021 | Human | Colorectum | FAP | 1.56e-04 | 3.58e-01 | 0.1171 |
| 100507420 | LINC01605 | A015-C-106 | Human | Colorectum | FAP | 1.10e-04 | 3.79e-01 | -0.0511 |
| 100507420 | LINC01605 | A002-C-016 | Human | Colorectum | FAP | 4.59e-02 | 2.79e-01 | 0.0521 |
| 100507420 | LINC01605 | A002-C-116 | Human | Colorectum | FAP | 5.45e-04 | 1.10e-01 | -0.0452 |
| 100507420 | LINC01605 | F034 | Human | Colorectum | FAP | 4.11e-12 | 5.84e-01 | -0.0665 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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