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Gene: LINC00998 |
Gene summary for LINC00998 |
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Gene information | Species | Human | Gene symbol | LINC00998 | Gene ID | 401397 |
Gene name | small integral membrane protein 30 | |
Gene Alias | LINC00998 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | NA |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
401397 | LINC00998 | P1T-E | Human | Esophagus | ESCC | 1.33e-05 | 3.40e-01 | 0.0875 |
401397 | LINC00998 | P2T-E | Human | Esophagus | ESCC | 1.85e-21 | 2.03e-01 | 0.1177 |
401397 | LINC00998 | P4T-E | Human | Esophagus | ESCC | 1.19e-23 | 5.83e-01 | 0.1323 |
401397 | LINC00998 | P5T-E | Human | Esophagus | ESCC | 5.05e-23 | 4.55e-01 | 0.1327 |
401397 | LINC00998 | P8T-E | Human | Esophagus | ESCC | 3.93e-38 | 7.86e-01 | 0.0889 |
401397 | LINC00998 | P9T-E | Human | Esophagus | ESCC | 8.95e-16 | 4.56e-01 | 0.1131 |
401397 | LINC00998 | P10T-E | Human | Esophagus | ESCC | 2.86e-26 | 4.66e-01 | 0.116 |
401397 | LINC00998 | P11T-E | Human | Esophagus | ESCC | 7.37e-13 | 4.11e-01 | 0.1426 |
401397 | LINC00998 | P12T-E | Human | Esophagus | ESCC | 4.30e-25 | 5.20e-01 | 0.1122 |
401397 | LINC00998 | P15T-E | Human | Esophagus | ESCC | 9.50e-17 | 4.77e-01 | 0.1149 |
401397 | LINC00998 | P16T-E | Human | Esophagus | ESCC | 4.71e-20 | 5.61e-01 | 0.1153 |
401397 | LINC00998 | P17T-E | Human | Esophagus | ESCC | 3.22e-03 | 2.30e-01 | 0.1278 |
401397 | LINC00998 | P19T-E | Human | Esophagus | ESCC | 4.21e-06 | 8.91e-01 | 0.1662 |
401397 | LINC00998 | P20T-E | Human | Esophagus | ESCC | 2.56e-17 | 4.37e-01 | 0.1124 |
401397 | LINC00998 | P21T-E | Human | Esophagus | ESCC | 1.56e-37 | 8.41e-01 | 0.1617 |
401397 | LINC00998 | P22T-E | Human | Esophagus | ESCC | 8.17e-20 | 3.06e-01 | 0.1236 |
401397 | LINC00998 | P23T-E | Human | Esophagus | ESCC | 1.15e-03 | 5.72e-02 | 0.108 |
401397 | LINC00998 | P24T-E | Human | Esophagus | ESCC | 8.59e-20 | 3.75e-01 | 0.1287 |
401397 | LINC00998 | P26T-E | Human | Esophagus | ESCC | 9.14e-50 | 8.60e-01 | 0.1276 |
401397 | LINC00998 | P27T-E | Human | Esophagus | ESCC | 1.91e-23 | 4.29e-01 | 0.1055 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LINC00998 | SNV | Missense_Mutation | novel | c.80N>T | p.Ala27Val | p.A27V | A4D0T7 | protein_coding | deleterious(0.01) | benign(0.351) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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