Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: LINC00869

Gene summary for LINC00869

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

LINC00869

Gene ID

57234

Gene namelong intergenic non-protein coding RNA 869
Gene AliasFAM91A2
Cytomap1q21.2
Gene TypencRNA
GO ID

GO:0006810

UniProtAcc

NA


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
57234LINC00869HTA11_3410_2000001011HumanColorectumAD5.48e-162.97e-010.0155
57234LINC00869HTA11_2487_2000001011HumanColorectumSER5.91e-123.32e-01-0.1808
57234LINC00869HTA11_2951_2000001011HumanColorectumAD3.40e-032.22e-010.0216
57234LINC00869HTA11_1938_2000001011HumanColorectumAD8.58e-134.12e-01-0.0811
57234LINC00869HTA11_78_2000001011HumanColorectumAD7.85e-133.85e-01-0.1088
57234LINC00869HTA11_347_2000001011HumanColorectumAD5.79e-326.71e-01-0.1954
57234LINC00869HTA11_411_2000001011HumanColorectumSER5.61e-032.55e-01-0.2602
57234LINC00869HTA11_2112_2000001011HumanColorectumSER1.29e-053.07e-01-0.2196
57234LINC00869HTA11_3361_2000001011HumanColorectumAD1.09e-062.57e-01-0.1207
57234LINC00869HTA11_696_2000001011HumanColorectumAD3.31e-193.26e-01-0.1464
57234LINC00869HTA11_866_2000001011HumanColorectumAD7.63e-193.77e-01-0.1001
57234LINC00869HTA11_1391_2000001011HumanColorectumAD2.21e-082.38e-01-0.059
57234LINC00869HTA11_2992_2000001011HumanColorectumSER1.09e-022.14e-01-0.1706
57234LINC00869HTA11_546_2000001011HumanColorectumAD6.64e-165.67e-01-0.0842
57234LINC00869HTA11_9341_2000001011HumanColorectumSER4.01e-043.68e-01-0.00410000000000005
57234LINC00869HTA11_7862_2000001011HumanColorectumAD3.59e-093.39e-01-0.0179
57234LINC00869HTA11_866_3004761011HumanColorectumAD1.19e-254.68e-010.096
57234LINC00869HTA11_4255_2000001011HumanColorectumSER3.34e-042.80e-010.0446
57234LINC00869HTA11_9408_2000001011HumanColorectumAD7.79e-043.72e-010.0451
57234LINC00869HTA11_8622_2000001021HumanColorectumSER1.49e-062.67e-010.0528
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0051656ColorectumADestablishment of organelle localization131/3918390/187233.00e-092.06e-07131
GO:0051650ColorectumADestablishment of vesicle localization57/3918161/187231.47e-053.15e-0457
GO:0051648ColorectumADvesicle localization59/3918177/187237.83e-051.25e-0359
GO:0006903ColorectumADvesicle targeting19/391845/187239.94e-049.28e-0319
GO:00516561ColorectumSERestablishment of organelle localization100/2897390/187231.11e-076.79e-06100
GO:00516501ColorectumSERestablishment of vesicle localization42/2897161/187233.38e-045.35e-0342
GO:00516481ColorectumSERvesicle localization43/2897177/187231.41e-031.53e-0243
GO:00069031ColorectumSERvesicle targeting14/289745/187236.36e-034.57e-0214
GO:00516562ColorectumMSSestablishment of organelle localization115/3467390/187237.30e-083.67e-06115
GO:00516502ColorectumMSSestablishment of vesicle localization51/3467161/187233.92e-057.45e-0451
GO:00516482ColorectumMSSvesicle localization53/3467177/187231.47e-042.16e-0353
GO:00069032ColorectumMSSvesicle targeting17/346745/187231.89e-031.65e-0217
GO:005165617EsophagusESCCestablishment of organelle localization273/8552390/187239.13e-231.81e-20273
GO:005165016EsophagusESCCestablishment of vesicle localization114/8552161/187238.20e-112.53e-09114
GO:005164815EsophagusESCCvesicle localization119/8552177/187235.16e-091.08e-07119
GO:00069038EsophagusESCCvesicle targeting38/855245/187238.42e-081.43e-0638
GO:00990222EsophagusESCCvesicle tethering10/855211/187232.54e-031.08e-0210
GO:005165610Oral cavityOSCCestablishment of organelle localization239/7305390/187232.46e-193.31e-17239
GO:00069037Oral cavityOSCCvesicle targeting38/730545/187234.49e-101.19e-0838
GO:00516509Oral cavityOSCCestablishment of vesicle localization101/7305161/187238.79e-102.17e-08101
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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