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Gene: LINC00640 |
Gene summary for LINC00640 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LINC00640 | Gene ID | 283553 |
| Gene name | long intergenic non-protein coding RNA 640 | |
| Gene Alias | LINC00640 | |
| Cytomap | 14q22.1 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 283553 | LINC00640 | LZE4T | Human | Esophagus | ESCC | 1.86e-04 | 1.63e-01 | 0.0811 |
| 283553 | LINC00640 | P2T-E | Human | Esophagus | ESCC | 7.75e-08 | 1.04e-01 | 0.1177 |
| 283553 | LINC00640 | P10T-E | Human | Esophagus | ESCC | 5.06e-33 | 7.07e-01 | 0.116 |
| 283553 | LINC00640 | P12T-E | Human | Esophagus | ESCC | 1.88e-11 | 2.85e-01 | 0.1122 |
| 283553 | LINC00640 | P15T-E | Human | Esophagus | ESCC | 4.53e-07 | 2.05e-01 | 0.1149 |
| 283553 | LINC00640 | P21T-E | Human | Esophagus | ESCC | 6.99e-04 | 7.34e-02 | 0.1617 |
| 283553 | LINC00640 | P22T-E | Human | Esophagus | ESCC | 1.25e-03 | 1.54e-01 | 0.1236 |
| 283553 | LINC00640 | P23T-E | Human | Esophagus | ESCC | 9.91e-05 | 1.36e-01 | 0.108 |
| 283553 | LINC00640 | P27T-E | Human | Esophagus | ESCC | 1.49e-07 | 1.96e-01 | 0.1055 |
| 283553 | LINC00640 | P30T-E | Human | Esophagus | ESCC | 1.17e-06 | 2.48e-01 | 0.137 |
| 283553 | LINC00640 | P31T-E | Human | Esophagus | ESCC | 3.18e-03 | 7.04e-02 | 0.1251 |
| 283553 | LINC00640 | P42T-E | Human | Esophagus | ESCC | 1.97e-08 | 2.31e-01 | 0.1175 |
| 283553 | LINC00640 | P49T-E | Human | Esophagus | ESCC | 1.42e-10 | 1.07e+00 | 0.1768 |
| 283553 | LINC00640 | P62T-E | Human | Esophagus | ESCC | 2.99e-03 | 8.58e-02 | 0.1302 |
| 283553 | LINC00640 | P65T-E | Human | Esophagus | ESCC | 1.79e-08 | 2.12e-01 | 0.0978 |
| 283553 | LINC00640 | P80T-E | Human | Esophagus | ESCC | 2.67e-07 | 2.31e-01 | 0.155 |
| 283553 | LINC00640 | P83T-E | Human | Esophagus | ESCC | 3.91e-03 | 1.07e-01 | 0.1738 |
| 283553 | LINC00640 | P91T-E | Human | Esophagus | ESCC | 1.01e-06 | 4.95e-01 | 0.1828 |
| 283553 | LINC00640 | P127T-E | Human | Esophagus | ESCC | 4.13e-03 | 1.19e-01 | 0.0826 |
| 283553 | LINC00640 | P130T-E | Human | Esophagus | ESCC | 8.65e-21 | 4.63e-01 | 0.1676 |
| Page: 1 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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