|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: LINC00486 |
Gene summary for LINC00486 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LINC00486 | Gene ID | 285045 |
| Gene name | long intergenic non-protein coding RNA 486 | |
| Gene Alias | LINC00486 | |
| Cytomap | 2p22.3 | |
| Gene Type | ncRNA | GO ID | NA | UniProtAcc | NA |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 285045 | LINC00486 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.29e-24 | -5.26e-01 | 0.0155 |
| 285045 | LINC00486 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.13e-14 | -5.26e-01 | -0.1808 |
| 285045 | LINC00486 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.37e-02 | -5.26e-01 | 0.0216 |
| 285045 | LINC00486 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.29e-10 | -5.26e-01 | -0.0811 |
| 285045 | LINC00486 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.13e-16 | -5.26e-01 | -0.1088 |
| 285045 | LINC00486 | HTA11_347_2000001011 | Human | Colorectum | AD | 8.82e-26 | -5.26e-01 | -0.1954 |
| 285045 | LINC00486 | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.75e-02 | -5.26e-01 | -0.2196 |
| 285045 | LINC00486 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.81e-11 | -5.26e-01 | -0.1207 |
| 285045 | LINC00486 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.71e-09 | -5.26e-01 | -0.1526 |
| 285045 | LINC00486 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.45e-30 | -5.26e-01 | -0.1464 |
| 285045 | LINC00486 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.54e-31 | -5.26e-01 | -0.1001 |
| 285045 | LINC00486 | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.03e-19 | -5.26e-01 | -0.059 |
| 285045 | LINC00486 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.20e-03 | -5.26e-01 | -0.1706 |
| 285045 | LINC00486 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.02e-04 | -5.26e-01 | -0.2061 |
| 285045 | LINC00486 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.37e-02 | -5.26e-01 | -0.1462 |
| 285045 | LINC00486 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.79e-07 | -5.26e-01 | -0.0842 |
| 285045 | LINC00486 | HTA11_7862_2000001011 | Human | Colorectum | AD | 6.44e-06 | -5.26e-01 | -0.0179 |
| 285045 | LINC00486 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.58e-21 | -5.26e-01 | 0.096 |
| 285045 | LINC00486 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.37e-02 | -5.26e-01 | 0.0446 |
| 285045 | LINC00486 | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.42e-05 | -5.26e-01 | 0.0528 |
| Page: 1 2 3 4 5 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Lung |  | AAH: Atypical adenomatous hyperplasia |
| AIS: Adenocarcinoma in situ | ||
| IAC: Invasive lung adenocarcinoma | ||
| MIA: Minimally invasive adenocarcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| Page: 1 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |