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Gene: LIN7B |
Gene summary for LIN7B |
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Gene information | Species | Human | Gene symbol | LIN7B | Gene ID | 64130 |
Gene name | lin-7 homolog B, crumbs cell polarity complex component | |
Gene Alias | LIN-7B | |
Cytomap | 19q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001505 | UniProtAcc | Q9HAP6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64130 | LIN7B | LZE2T | Human | Esophagus | ESCC | 6.83e-03 | 3.30e-01 | 0.082 |
64130 | LIN7B | LZE22T | Human | Esophagus | ESCC | 3.02e-02 | 1.89e-01 | 0.068 |
64130 | LIN7B | LZE24T | Human | Esophagus | ESCC | 8.36e-08 | 2.06e-01 | 0.0596 |
64130 | LIN7B | LZE21T | Human | Esophagus | ESCC | 1.22e-02 | 1.74e-01 | 0.0655 |
64130 | LIN7B | P1T-E | Human | Esophagus | ESCC | 1.02e-05 | 2.45e-01 | 0.0875 |
64130 | LIN7B | P2T-E | Human | Esophagus | ESCC | 5.34e-07 | 3.73e-02 | 0.1177 |
64130 | LIN7B | P4T-E | Human | Esophagus | ESCC | 2.55e-11 | 2.59e-01 | 0.1323 |
64130 | LIN7B | P5T-E | Human | Esophagus | ESCC | 1.57e-04 | 6.06e-02 | 0.1327 |
64130 | LIN7B | P8T-E | Human | Esophagus | ESCC | 1.18e-13 | 2.70e-01 | 0.0889 |
64130 | LIN7B | P9T-E | Human | Esophagus | ESCC | 5.48e-05 | 1.30e-01 | 0.1131 |
64130 | LIN7B | P10T-E | Human | Esophagus | ESCC | 8.52e-23 | 3.34e-01 | 0.116 |
64130 | LIN7B | P11T-E | Human | Esophagus | ESCC | 1.84e-06 | 2.75e-01 | 0.1426 |
64130 | LIN7B | P12T-E | Human | Esophagus | ESCC | 2.00e-14 | 2.06e-01 | 0.1122 |
64130 | LIN7B | P15T-E | Human | Esophagus | ESCC | 5.19e-13 | 2.72e-01 | 0.1149 |
64130 | LIN7B | P16T-E | Human | Esophagus | ESCC | 1.75e-07 | 8.34e-02 | 0.1153 |
64130 | LIN7B | P17T-E | Human | Esophagus | ESCC | 1.67e-02 | 1.57e-01 | 0.1278 |
64130 | LIN7B | P21T-E | Human | Esophagus | ESCC | 2.23e-11 | 1.43e-01 | 0.1617 |
64130 | LIN7B | P22T-E | Human | Esophagus | ESCC | 1.08e-18 | 3.14e-01 | 0.1236 |
64130 | LIN7B | P23T-E | Human | Esophagus | ESCC | 7.12e-17 | 3.86e-01 | 0.108 |
64130 | LIN7B | P24T-E | Human | Esophagus | ESCC | 1.48e-06 | 1.10e-01 | 0.1287 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
GO:00350888 | Esophagus | ESCC | establishment or maintenance of apical/basal cell polarity | 32/8552 | 49/18723 | 4.39e-03 | 1.73e-02 | 32 |
GO:00612458 | Esophagus | ESCC | establishment or maintenance of bipolar cell polarity | 32/8552 | 49/18723 | 4.39e-03 | 1.73e-02 | 32 |
GO:00451978 | Esophagus | ESCC | establishment or maintenance of epithelial cell apical/basal polarity | 29/8552 | 44/18723 | 5.41e-03 | 2.02e-02 | 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LIN7B | SNV | Missense_Mutation | novel | c.344N>T | p.Ser115Leu | p.S115L | Q9HAP6 | protein_coding | deleterious(0.03) | possibly_damaging(0.874) | TCGA-BH-A2L8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR |
LIN7B | SNV | Missense_Mutation | novel | c.202N>A | p.Glu68Lys | p.E68K | Q9HAP6 | protein_coding | deleterious(0.01) | possibly_damaging(0.821) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LIN7B | SNV | Missense_Mutation | novel | c.258G>T | p.Glu86Asp | p.E86D | Q9HAP6 | protein_coding | tolerated(0.1) | probably_damaging(0.997) | TCGA-G4-6309-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | PD |
LIN7B | SNV | Missense_Mutation | novel | c.497C>T | p.Ser166Leu | p.S166L | Q9HAP6 | protein_coding | deleterious(0.02) | benign(0.067) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIN7B | SNV | Missense_Mutation | novel | c.392A>G | p.His131Arg | p.H131R | Q9HAP6 | protein_coding | deleterious(0.05) | benign(0.219) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LIN7B | SNV | Missense_Mutation | novel | c.497C>T | p.Ser166Leu | p.S166L | Q9HAP6 | protein_coding | deleterious(0.02) | benign(0.067) | TCGA-A5-A0GG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LIN7B | SNV | Missense_Mutation | rs747454634 | c.485C>T | p.Ala162Val | p.A162V | Q9HAP6 | protein_coding | tolerated(0.07) | possibly_damaging(0.523) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LIN7B | SNV | Missense_Mutation | c.406C>T | p.Arg136Cys | p.R136C | Q9HAP6 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LIN7B | SNV | Missense_Mutation | novel | c.551G>T | p.Arg184Leu | p.R184L | Q9HAP6 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LIN7B | SNV | Missense_Mutation | novel | c.329N>A | p.Gly110Asp | p.G110D | Q9HAP6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A1E1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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