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Gene: LHFPL5 |
Gene summary for LHFPL5 |
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Gene information | Species | Human | Gene symbol | LHFPL5 | Gene ID | 222662 |
Gene name | LHFPL tetraspan subfamily member 5 | |
Gene Alias | DFNB67 | |
Cytomap | 6p21.31 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q8TAF8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
222662 | LHFPL5 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.72e-05 | 1.32e-01 | -0.1954 |
222662 | LHFPL5 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.04e-05 | 1.19e-01 | -0.1464 |
222662 | LHFPL5 | HTA11_6801_2000001011 | Human | Colorectum | SER | 7.64e-10 | 5.73e-01 | 0.0171 |
222662 | LHFPL5 | HTA11_7469_2000001011 | Human | Colorectum | AD | 4.71e-07 | 4.55e-01 | -0.0124 |
222662 | LHFPL5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.73e-12 | 3.05e-01 | 0.3859 |
222662 | LHFPL5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.61e-02 | 9.17e-02 | 0.3005 |
222662 | LHFPL5 | RNA-P17T-P17T-2 | Human | Lung | IAC | 5.30e-08 | 6.82e-01 | 0.3371 |
222662 | LHFPL5 | RNA-P17T-P17T-4 | Human | Lung | IAC | 1.13e-06 | 6.15e-01 | 0.343 |
222662 | LHFPL5 | RNA-P17T-P17T-6 | Human | Lung | IAC | 9.84e-12 | 1.03e+00 | 0.3385 |
222662 | LHFPL5 | RNA-P17T-P17T-8 | Human | Lung | IAC | 5.26e-09 | 8.27e-01 | 0.3329 |
222662 | LHFPL5 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.13e-05 | 2.41e-01 | -0.0166 |
222662 | LHFPL5 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.68e-04 | 2.18e-01 | -0.0132 |
222662 | LHFPL5 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.30e-03 | 1.67e-01 | -0.013 |
222662 | LHFPL5 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 5.32e-06 | 2.42e-01 | -0.0121 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0035315 | Colorectum | AD | hair cell differentiation | 21/3918 | 47/18723 | 2.14e-04 | 2.82e-03 | 21 |
GO:0060117 | Colorectum | AD | auditory receptor cell development | 12/3918 | 21/18723 | 3.02e-04 | 3.62e-03 | 12 |
GO:0042491 | Colorectum | AD | inner ear auditory receptor cell differentiation | 17/3918 | 38/18723 | 8.26e-04 | 8.13e-03 | 17 |
GO:0060088 | Colorectum | AD | auditory receptor cell stereocilium organization | 8/3918 | 14/18723 | 3.23e-03 | 2.38e-02 | 8 |
GO:0042490 | Colorectum | AD | mechanoreceptor differentiation | 24/3918 | 67/18723 | 3.48e-03 | 2.52e-02 | 24 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:0009913 | Colorectum | AD | epidermal cell differentiation | 58/3918 | 202/18723 | 5.16e-03 | 3.42e-02 | 58 |
GO:0008544 | Colorectum | AD | epidermis development | 87/3918 | 324/18723 | 5.99e-03 | 3.76e-02 | 87 |
GO:0060119 | Colorectum | AD | inner ear receptor cell development | 17/3918 | 45/18723 | 7.10e-03 | 4.33e-02 | 17 |
GO:00020641 | Colorectum | SER | epithelial cell development | 64/2897 | 220/18723 | 1.96e-07 | 1.10e-05 | 64 |
GO:00601171 | Colorectum | SER | auditory receptor cell development | 9/2897 | 21/18723 | 2.50e-03 | 2.33e-02 | 9 |
GO:00600881 | Colorectum | SER | auditory receptor cell stereocilium organization | 7/2897 | 14/18723 | 2.64e-03 | 2.41e-02 | 7 |
GO:00353151 | Colorectum | SER | hair cell differentiation | 15/2897 | 47/18723 | 3.68e-03 | 3.07e-02 | 15 |
GO:0002093 | Colorectum | SER | auditory receptor cell morphogenesis | 7/2897 | 16/18723 | 6.63e-03 | 4.69e-02 | 7 |
GO:00020642 | Colorectum | MSS | epithelial cell development | 81/3467 | 220/18723 | 1.02e-10 | 1.06e-08 | 81 |
GO:00601172 | Colorectum | MSS | auditory receptor cell development | 12/3467 | 21/18723 | 8.83e-05 | 1.41e-03 | 12 |
GO:00353152 | Colorectum | MSS | hair cell differentiation | 19/3467 | 47/18723 | 3.88e-04 | 4.86e-03 | 19 |
GO:00424911 | Colorectum | MSS | inner ear auditory receptor cell differentiation | 16/3467 | 38/18723 | 6.47e-04 | 7.06e-03 | 16 |
GO:00600882 | Colorectum | MSS | auditory receptor cell stereocilium organization | 8/3467 | 14/18723 | 1.42e-03 | 1.32e-02 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LHFPL5 | SNV | Missense_Mutation | rs866338176 | c.226G>A | p.Glu76Lys | p.E76K | Q8TAF8 | protein_coding | tolerated(0.06) | probably_damaging(0.995) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LHFPL5 | SNV | Missense_Mutation | novel | c.520N>C | p.Thr174Pro | p.T174P | Q8TAF8 | protein_coding | deleterious(0.01) | possibly_damaging(0.61) | TCGA-D8-A1XQ-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LHFPL5 | SNV | Missense_Mutation | c.16N>T | p.Pro6Ser | p.P6S | Q8TAF8 | protein_coding | deleterious_low_confidence(0.03) | benign(0.021) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LHFPL5 | SNV | Missense_Mutation | rs750723647 | c.205G>A | p.Val69Met | p.V69M | Q8TAF8 | protein_coding | tolerated(0.06) | benign(0.441) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
LHFPL5 | SNV | Missense_Mutation | novel | c.65N>T | p.Ser22Leu | p.S22L | Q8TAF8 | protein_coding | deleterious(0) | benign(0.015) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LHFPL5 | SNV | Missense_Mutation | c.36N>T | p.Lys12Asn | p.K12N | Q8TAF8 | protein_coding | deleterious(0.01) | benign(0.073) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LHFPL5 | SNV | Missense_Mutation | rs766245505 | c.73N>A | p.Val25Met | p.V25M | Q8TAF8 | protein_coding | deleterious(0.04) | benign(0.035) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
LHFPL5 | SNV | Missense_Mutation | novel | c.254N>T | p.Asp85Val | p.D85V | Q8TAF8 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LHFPL5 | SNV | Missense_Mutation | rs774822686 | c.58N>T | p.Arg20Trp | p.R20W | Q8TAF8 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
LHFPL5 | SNV | Missense_Mutation | c.275N>T | p.Arg92Ile | p.R92I | Q8TAF8 | protein_coding | tolerated(0.12) | benign(0.14) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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