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Gene: LHFPL3 |
Gene summary for LHFPL3 |
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Gene information | Species | Human | Gene symbol | LHFPL3 | Gene ID | 375612 |
Gene name | LHFPL tetraspan subfamily member 3 | |
Gene Alias | LHFPL4 | |
Cytomap | 7q22.2-q22.3 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q86UP9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375612 | LHFPL3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.96e-26 | 6.91e-01 | 0.0155 |
375612 | LHFPL3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.08e-21 | 8.26e-01 | -0.1808 |
375612 | LHFPL3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.51e-25 | 1.08e+00 | -0.0811 |
375612 | LHFPL3 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.08e-40 | 1.43e+00 | -0.1088 |
375612 | LHFPL3 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.00e-37 | 9.39e-01 | -0.1954 |
375612 | LHFPL3 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.12e-20 | 1.04e+00 | -0.1526 |
375612 | LHFPL3 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.34e-13 | 5.01e-01 | -0.1464 |
375612 | LHFPL3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.44e-09 | 4.44e-01 | -0.1001 |
375612 | LHFPL3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.31e-22 | 8.03e-01 | -0.059 |
375612 | LHFPL3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.58e-07 | 5.66e-01 | -0.1706 |
375612 | LHFPL3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 6.85e-06 | 5.24e-01 | -0.2061 |
375612 | LHFPL3 | HTA11_546_2000001011 | Human | Colorectum | AD | 5.64e-09 | 6.67e-01 | -0.0842 |
375612 | LHFPL3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.08e-07 | 8.88e-01 | -0.00410000000000005 |
375612 | LHFPL3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 4.22e-10 | 6.46e-01 | -0.0179 |
375612 | LHFPL3 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.25e-36 | 9.39e-01 | 0.096 |
375612 | LHFPL3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.26e-20 | 1.22e+00 | 0.0446 |
375612 | LHFPL3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.98e-14 | 9.36e-01 | 0.0528 |
375612 | LHFPL3 | HTA11_7663_2000001011 | Human | Colorectum | SER | 8.85e-23 | 1.57e+00 | 0.0131 |
375612 | LHFPL3 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.20e-14 | 9.32e-01 | -0.0177 |
375612 | LHFPL3 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.83e-19 | 1.55e+00 | 0.0171 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LHFPL3 | insertion | Frame_Shift_Ins | novel | c.596_597insTTTGAACTATAGTTTGAATTCAAAGATCTTCTGCATCCTCCAA | p.Gln200LeufsTer45 | p.Q200Lfs*45 | Q86UP9 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
LHFPL3 | insertion | In_Frame_Ins | novel | c.234_235insGTCTCCTGCGCGCTGAGAGGCGGGGGGAGGCGGAGGACCAGGAGGAGG | p.Gly78_Ser79insValSerCysAlaLeuArgGlyGlyGlyArgArgArgThrArgArgArg | p.G78_S79insVSCALRGGGRRRTRRR | Q86UP9 | protein_coding | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
LHFPL3 | SNV | Missense_Mutation | novel | c.315C>G | p.Ile105Met | p.I105M | Q86UP9 | protein_coding | deleterious(0.01) | possibly_damaging(0.675) | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
LHFPL3 | SNV | Missense_Mutation | novel | c.56N>T | p.Ser19Leu | p.S19L | Q86UP9 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LHFPL3 | SNV | Missense_Mutation | c.142N>A | p.Gly48Ser | p.G48S | Q86UP9 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LHFPL3 | SNV | Missense_Mutation | c.61G>A | p.Ala21Thr | p.A21T | Q86UP9 | protein_coding | deleterious(0) | possibly_damaging(0.792) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
LHFPL3 | SNV | Missense_Mutation | c.110N>C | p.Asn37Thr | p.N37T | Q86UP9 | protein_coding | tolerated(0.44) | possibly_damaging(0.908) | TCGA-D5-6931-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
LHFPL3 | SNV | Missense_Mutation | c.557C>T | p.Ala186Val | p.A186V | Q86UP9 | protein_coding | deleterious(0.03) | probably_damaging(0.973) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LHFPL3 | SNV | Missense_Mutation | novel | c.517N>T | p.Arg173Cys | p.R173C | Q86UP9 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
LHFPL3 | SNV | Missense_Mutation | c.638A>G | p.Lys213Arg | p.K213R | Q86UP9 | protein_coding | tolerated(0.06) | benign(0.06) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
375612 | LHFPL3 | NA | corticosteroids | 30697902 |
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