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Gene: LGR4 |
Gene summary for LGR4 |
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Gene information | Species | Human | Gene symbol | LGR4 | Gene ID | 55366 |
Gene name | leucine rich repeat containing G protein-coupled receptor 4 | |
Gene Alias | BNMD17 | |
Cytomap | 11p14.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q59ER8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55366 | LGR4 | CA_HPV_3 | Human | Cervix | CC | 4.30e-02 | 1.27e-01 | 0.0414 |
55366 | LGR4 | CCI_2 | Human | Cervix | CC | 9.15e-08 | 1.26e+00 | 0.5249 |
55366 | LGR4 | CCI_3 | Human | Cervix | CC | 6.74e-16 | 1.03e+00 | 0.516 |
55366 | LGR4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.44e-16 | -6.40e-01 | 0.0155 |
55366 | LGR4 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.57e-10 | 7.01e-01 | -0.1954 |
55366 | LGR4 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.07e-02 | 6.68e-01 | -0.2602 |
55366 | LGR4 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.70e-12 | -6.48e-01 | 0.096 |
55366 | LGR4 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.25e-09 | -5.88e-01 | 0.0338 |
55366 | LGR4 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.48e-04 | -4.70e-01 | 0.0674 |
55366 | LGR4 | HTA11_7469_2000001011 | Human | Colorectum | AD | 8.95e-04 | -3.38e-01 | -0.0124 |
55366 | LGR4 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.14e-06 | -5.77e-01 | 0.0588 |
55366 | LGR4 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.93e-20 | -6.47e-01 | 0.294 |
55366 | LGR4 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.25e-08 | -4.64e-01 | 0.3859 |
55366 | LGR4 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.41e-12 | -8.76e-01 | 0.2585 |
55366 | LGR4 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.26e-44 | -9.85e-01 | 0.3005 |
55366 | LGR4 | F007 | Human | Colorectum | FAP | 2.09e-02 | -3.76e-01 | 0.1176 |
55366 | LGR4 | A001-C-207 | Human | Colorectum | FAP | 1.20e-05 | -4.36e-01 | 0.1278 |
55366 | LGR4 | A015-C-203 | Human | Colorectum | FAP | 8.86e-51 | -9.35e-01 | -0.1294 |
55366 | LGR4 | A015-C-204 | Human | Colorectum | FAP | 4.38e-14 | -6.60e-01 | -0.0228 |
55366 | LGR4 | A014-C-040 | Human | Colorectum | FAP | 2.06e-10 | -8.47e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00027644 | Cervix | CC | immune response-regulating signaling pathway | 97/2311 | 468/18723 | 1.49e-07 | 7.07e-06 | 97 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00608287 | Cervix | CC | regulation of canonical Wnt signaling pathway | 58/2311 | 253/18723 | 1.83e-06 | 5.89e-05 | 58 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:004887210 | Cervix | CC | homeostasis of number of cells | 61/2311 | 272/18723 | 2.17e-06 | 6.55e-05 | 61 |
GO:00600707 | Cervix | CC | canonical Wnt signaling pathway | 66/2311 | 303/18723 | 2.47e-06 | 7.35e-05 | 66 |
GO:00485118 | Cervix | CC | rhythmic process | 65/2311 | 298/18723 | 2.79e-06 | 8.04e-05 | 65 |
GO:00076238 | Cervix | CC | circadian rhythm | 46/2311 | 210/18723 | 6.76e-05 | 9.60e-04 | 46 |
GO:00022212 | Cervix | CC | pattern recognition receptor signaling pathway | 39/2311 | 172/18723 | 1.08e-04 | 1.38e-03 | 39 |
GO:00622073 | Cervix | CC | regulation of pattern recognition receptor signaling pathway | 27/2311 | 105/18723 | 1.37e-04 | 1.68e-03 | 27 |
GO:00016497 | Cervix | CC | osteoblast differentiation | 47/2311 | 229/18723 | 2.88e-04 | 3.11e-03 | 47 |
GO:00301776 | Cervix | CC | positive regulation of Wnt signaling pathway | 31/2311 | 140/18723 | 8.01e-04 | 7.02e-03 | 31 |
GO:00329226 | Cervix | CC | circadian regulation of gene expression | 18/2311 | 68/18723 | 1.18e-03 | 9.56e-03 | 18 |
GO:00015037 | Cervix | CC | ossification | 71/2311 | 408/18723 | 1.67e-03 | 1.28e-02 | 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa043109 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa0431012 | Cervix | CC | Wnt signaling pathway | 43/1267 | 171/8465 | 3.03e-04 | 1.64e-03 | 9.68e-04 | 43 |
hsa04310 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa043101 | Colorectum | AD | Wnt signaling pathway | 56/2092 | 171/8465 | 1.03e-02 | 3.93e-02 | 2.51e-02 | 56 |
hsa043102 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
hsa043103 | Colorectum | MSS | Wnt signaling pathway | 53/1875 | 171/8465 | 4.24e-03 | 1.86e-02 | 1.14e-02 | 53 |
hsa043104 | Colorectum | FAP | Wnt signaling pathway | 46/1404 | 171/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 46 |
hsa043105 | Colorectum | FAP | Wnt signaling pathway | 46/1404 | 171/8465 | 3.94e-04 | 3.06e-03 | 1.86e-03 | 46 |
hsa043106 | Colorectum | CRC | Wnt signaling pathway | 40/1091 | 171/8465 | 1.01e-04 | 1.57e-03 | 1.07e-03 | 40 |
hsa043107 | Colorectum | CRC | Wnt signaling pathway | 40/1091 | 171/8465 | 1.01e-04 | 1.57e-03 | 1.07e-03 | 40 |
hsa0431010 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431013 | Endometrium | AEH | Wnt signaling pathway | 37/1197 | 171/8465 | 4.68e-03 | 2.53e-02 | 1.86e-02 | 37 |
hsa0431022 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa0431032 | Endometrium | EEC | Wnt signaling pathway | 40/1237 | 171/8465 | 1.37e-03 | 8.99e-03 | 6.70e-03 | 40 |
hsa043108 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0431011 | Lung | IAC | Wnt signaling pathway | 40/1053 | 171/8465 | 4.56e-05 | 7.06e-04 | 4.69e-04 | 40 |
hsa0431021 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0431031 | Lung | AIS | Wnt signaling pathway | 39/961 | 171/8465 | 1.29e-05 | 3.32e-04 | 2.12e-04 | 39 |
hsa0431014 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
hsa0431015 | Prostate | BPH | Wnt signaling pathway | 50/1718 | 171/8465 | 3.11e-03 | 1.15e-02 | 7.14e-03 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGR4 | SNV | Missense_Mutation | novel | c.1817N>T | p.Ala606Val | p.A606V | Q9BXB1 | protein_coding | deleterious(0) | possibly_damaging(0.756) | TCGA-A2-A4S1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LGR4 | SNV | Missense_Mutation | rs749587915 | c.466N>T | p.Arg156Trp | p.R156W | Q9BXB1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A0XU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LGR4 | SNV | Missense_Mutation | c.1968N>A | p.Ser656Arg | p.S656R | Q9BXB1 | protein_coding | tolerated(0.3) | benign(0.007) | TCGA-C8-A134-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
LGR4 | SNV | Missense_Mutation | c.539N>G | p.Gln180Arg | p.Q180R | Q9BXB1 | protein_coding | tolerated(0.06) | possibly_damaging(0.782) | TCGA-D8-A147-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
LGR4 | insertion | Nonsense_Mutation | novel | c.508_509insCATTGTGATATTGAAAGTATA | p.Val170delinsAlaLeuTerTyrTerLysTyrMet | p.V170delinsAL*Y*KYM | Q9BXB1 | protein_coding | TCGA-A2-A0CQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
LGR4 | insertion | Frame_Shift_Ins | novel | c.573_574insGAAAT | p.Ile192GlufsTer15 | p.I192Efs*15 | Q9BXB1 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
LGR4 | SNV | Missense_Mutation | c.1953N>C | p.Met651Ile | p.M651I | Q9BXB1 | protein_coding | tolerated(0.45) | benign(0) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
LGR4 | SNV | Missense_Mutation | rs200626048 | c.1625N>A | p.Arg542His | p.R542H | Q9BXB1 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LGR4 | SNV | Missense_Mutation | c.2000N>G | p.Leu667Arg | p.L667R | Q9BXB1 | protein_coding | tolerated(0.08) | benign(0.419) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGR4 | SNV | Missense_Mutation | rs376236224 | c.274G>A | p.Asp92Asn | p.D92N | Q9BXB1 | protein_coding | tolerated(0.24) | possibly_damaging(0.735) | TCGA-A6-5661-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
55366 | LGR4 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100589 | ||
55366 | LGR4 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100587 | ||
55366 | LGR4 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100588 | ||
55366 | LGR4 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 178100586 |
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