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Gene: LGALS4 |
Gene summary for LGALS4 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LGALS4 | Gene ID | 3960 |
| Gene name | galectin 4 | |
| Gene Alias | GAL4 | |
| Cytomap | 19q13.2 | |
| Gene Type | protein-coding | GO ID | GO:0007155 | UniProtAcc | P56470 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3960 | LGALS4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.06e-32 | 1.06e+00 | 0.0155 |
| 3960 | LGALS4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.67e-48 | 3.32e+00 | -0.1808 |
| 3960 | LGALS4 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.19e-17 | 1.36e+00 | 0.0216 |
| 3960 | LGALS4 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.64e-40 | 2.59e+00 | -0.0811 |
| 3960 | LGALS4 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.77e-33 | 2.30e+00 | -0.1088 |
| 3960 | LGALS4 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.65e-76 | 3.38e+00 | -0.1954 |
| 3960 | LGALS4 | HTA11_411_2000001011 | Human | Colorectum | SER | 7.30e-31 | 3.82e+00 | -0.2602 |
| 3960 | LGALS4 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.79e-24 | 3.98e+00 | -0.2196 |
| 3960 | LGALS4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.33e-46 | 3.31e+00 | -0.1207 |
| 3960 | LGALS4 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.01e-48 | 3.54e+00 | -0.1526 |
| 3960 | LGALS4 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.24e-54 | 3.34e+00 | -0.1464 |
| 3960 | LGALS4 | HTA11_866_2000001011 | Human | Colorectum | AD | 5.36e-54 | 2.49e+00 | -0.1001 |
| 3960 | LGALS4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.34e-45 | 3.21e+00 | -0.059 |
| 3960 | LGALS4 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.25e-35 | 3.73e+00 | -0.1706 |
| 3960 | LGALS4 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.26e-45 | 3.47e+00 | -0.2061 |
| 3960 | LGALS4 | HTA11_5216_2000001011 | Human | Colorectum | SER | 8.44e-32 | 3.43e+00 | -0.1462 |
| 3960 | LGALS4 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.94e-35 | 2.63e+00 | -0.0842 |
| 3960 | LGALS4 | HTA11_9341_2000001011 | Human | Colorectum | SER | 2.23e-41 | 2.42e+00 | -0.00410000000000005 |
| 3960 | LGALS4 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.12e-44 | 2.45e+00 | -0.0179 |
| 3960 | LGALS4 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.01e-22 | 1.53e+00 | 0.096 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| GC |  | CAG: Chronic atrophic gastritis |
| CAG with IM: Chronic atrophic gastritis with intestinal metaplasia | ||
| CSG: Chronic superficial gastritis | ||
| GC: Gastric cancer | ||
| SIM: Severe intestinal metaplasia | ||
| WIM: Wild intestinal metaplasia | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| LGALS4 | SNV | Missense_Mutation | c.219N>T | p.Lys73Asn | p.K73N | P56470 | protein_coding | deleterious(0.01) | probably_damaging(0.923) | TCGA-BH-A0BW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | CR | |
| LGALS4 | SNV | Missense_Mutation | novel | c.571N>T | p.Pro191Ser | p.P191S | P56470 | protein_coding | tolerated(0.25) | benign(0.006) | TCGA-EW-A1P7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD |
| LGALS4 | SNV | Missense_Mutation | rs371360675 | c.719N>A | p.Arg240His | p.R240H | P56470 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| LGALS4 | SNV | Missense_Mutation | novel | c.203N>G | p.Phe68Cys | p.F68C | P56470 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-5M-AAT4-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
| LGALS4 | SNV | Missense_Mutation | rs761654023 | c.850N>T | p.Arg284Cys | p.R284C | P56470 | protein_coding | deleterious(0.04) | probably_damaging(0.992) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
| LGALS4 | SNV | Missense_Mutation | c.605N>G | p.Leu202Arg | p.L202R | P56470 | protein_coding | deleterious(0.02) | probably_damaging(0.997) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| LGALS4 | SNV | Missense_Mutation | c.819N>A | p.Phe273Leu | p.F273L | P56470 | protein_coding | deleterious(0.02) | benign(0.123) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| LGALS4 | SNV | Missense_Mutation | rs770991069 | c.115N>A | p.Ala39Thr | p.A39T | P56470 | protein_coding | tolerated(0.24) | benign(0.021) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| LGALS4 | SNV | Missense_Mutation | c.340G>C | p.Val114Leu | p.V114L | P56470 | protein_coding | deleterious(0.01) | possibly_damaging(0.706) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
| LGALS4 | SNV | Missense_Mutation | rs199814280 | c.905N>T | p.Ser302Leu | p.S302L | P56470 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-D5-6928-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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