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Gene: LEPROTL1 |
Gene summary for LEPROTL1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | LEPROTL1 | Gene ID | 23484 |
| Gene name | leptin receptor overlapping transcript like 1 | |
| Gene Alias | HSPC112 | |
| Cytomap | 8p12 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | O95214 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23484 | LEPROTL1 | LZE2T | Human | Esophagus | ESCC | 2.61e-05 | 6.64e-01 | 0.082 |
| 23484 | LEPROTL1 | LZE4T | Human | Esophagus | ESCC | 8.36e-25 | 6.58e-01 | 0.0811 |
| 23484 | LEPROTL1 | LZE7T | Human | Esophagus | ESCC | 1.16e-12 | 8.34e-01 | 0.0667 |
| 23484 | LEPROTL1 | LZE8T | Human | Esophagus | ESCC | 3.05e-15 | 3.85e-01 | 0.067 |
| 23484 | LEPROTL1 | LZE20T | Human | Esophagus | ESCC | 1.83e-07 | 3.05e-01 | 0.0662 |
| 23484 | LEPROTL1 | LZE22T | Human | Esophagus | ESCC | 3.82e-04 | 3.02e-01 | 0.068 |
| 23484 | LEPROTL1 | LZE24T | Human | Esophagus | ESCC | 1.46e-25 | 6.09e-01 | 0.0596 |
| 23484 | LEPROTL1 | LZE6T | Human | Esophagus | ESCC | 2.38e-23 | 1.04e+00 | 0.0845 |
| 23484 | LEPROTL1 | P1T-E | Human | Esophagus | ESCC | 1.41e-08 | 3.97e-01 | 0.0875 |
| 23484 | LEPROTL1 | P2T-E | Human | Esophagus | ESCC | 1.15e-41 | 6.80e-01 | 0.1177 |
| 23484 | LEPROTL1 | P4T-E | Human | Esophagus | ESCC | 1.15e-70 | 1.30e+00 | 0.1323 |
| 23484 | LEPROTL1 | P5T-E | Human | Esophagus | ESCC | 3.83e-20 | 3.95e-01 | 0.1327 |
| 23484 | LEPROTL1 | P8T-E | Human | Esophagus | ESCC | 3.13e-23 | 3.72e-01 | 0.0889 |
| 23484 | LEPROTL1 | P9T-E | Human | Esophagus | ESCC | 6.64e-28 | 6.03e-01 | 0.1131 |
| 23484 | LEPROTL1 | P10T-E | Human | Esophagus | ESCC | 6.19e-30 | 5.43e-01 | 0.116 |
| 23484 | LEPROTL1 | P11T-E | Human | Esophagus | ESCC | 6.35e-24 | 5.39e-01 | 0.1426 |
| 23484 | LEPROTL1 | P12T-E | Human | Esophagus | ESCC | 1.19e-24 | 4.95e-01 | 0.1122 |
| 23484 | LEPROTL1 | P15T-E | Human | Esophagus | ESCC | 1.20e-53 | 1.23e+00 | 0.1149 |
| 23484 | LEPROTL1 | P16T-E | Human | Esophagus | ESCC | 1.90e-33 | 6.81e-01 | 0.1153 |
| 23484 | LEPROTL1 | P17T-E | Human | Esophagus | ESCC | 1.60e-11 | 4.72e-01 | 0.1278 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:001619715 | Esophagus | ESCC | endosomal transport | 168/8552 | 230/18723 | 2.28e-17 | 1.93e-15 | 168 |
| GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
| GO:007198514 | Esophagus | ESCC | multivesicular body sorting pathway | 34/8552 | 37/18723 | 3.49e-09 | 7.39e-08 | 34 |
| GO:003250915 | Esophagus | ESCC | endosome transport via multivesicular body sorting pathway | 29/8552 | 31/18723 | 1.92e-08 | 3.72e-07 | 29 |
| GO:00453245 | Esophagus | ESCC | late endosome to vacuole transport | 23/8552 | 25/18723 | 1.39e-06 | 1.69e-05 | 23 |
| GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
| GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
| GO:00325113 | Esophagus | ESCC | late endosome to vacuole transport via multivesicular body sorting pathway | 16/8552 | 17/18723 | 3.46e-05 | 2.82e-04 | 16 |
| GO:007137516 | Esophagus | ESCC | cellular response to peptide hormone stimulus | 166/8552 | 290/18723 | 4.48e-05 | 3.55e-04 | 166 |
| GO:000703411 | Liver | Cirrhotic | vacuolar transport | 75/4634 | 157/18723 | 3.13e-10 | 1.53e-08 | 75 |
| GO:00325093 | Liver | Cirrhotic | endosome transport via multivesicular body sorting pathway | 24/4634 | 31/18723 | 1.06e-09 | 4.76e-08 | 24 |
| GO:00719853 | Liver | Cirrhotic | multivesicular body sorting pathway | 25/4634 | 37/18723 | 4.79e-08 | 1.52e-06 | 25 |
| GO:001619711 | Liver | Cirrhotic | endosomal transport | 93/4634 | 230/18723 | 1.01e-07 | 2.93e-06 | 93 |
| GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
| GO:007137511 | Liver | Cirrhotic | cellular response to peptide hormone stimulus | 110/4634 | 290/18723 | 3.73e-07 | 8.82e-06 | 110 |
| GO:00453242 | Liver | Cirrhotic | late endosome to vacuole transport | 18/4634 | 25/18723 | 8.88e-07 | 1.84e-05 | 18 |
| GO:190165311 | Liver | Cirrhotic | cellular response to peptide | 129/4634 | 359/18723 | 1.23e-06 | 2.49e-05 | 129 |
| GO:0032511 | Liver | Cirrhotic | late endosome to vacuole transport via multivesicular body sorting pathway | 12/4634 | 17/18723 | 8.92e-05 | 9.59e-04 | 12 |
| GO:001619721 | Liver | HCC | endosomal transport | 154/7958 | 230/18723 | 4.74e-14 | 2.95e-12 | 154 |
| GO:004343422 | Liver | HCC | response to peptide hormone | 247/7958 | 414/18723 | 9.55e-13 | 4.77e-11 | 247 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| LEPROTL1 | deletion | Frame_Shift_Del | novel | c.448delC | p.Leu150TrpfsTer9 | p.L150Wfs*9 | O95214 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
| LEPROTL1 | SNV | Missense_Mutation | c.193N>A | p.Ala65Thr | p.A65T | O95214 | protein_coding | deleterious(0.04) | possibly_damaging(0.82) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
| LEPROTL1 | SNV | Missense_Mutation | c.235G>A | p.Val79Met | p.V79M | O95214 | protein_coding | deleterious(0.02) | probably_damaging(0.989) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| LEPROTL1 | SNV | Missense_Mutation | novel | c.500N>G | p.Gln167Arg | p.Q167R | O95214 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| LEPROTL1 | SNV | Missense_Mutation | rs550518450 | c.370G>A | p.Ala124Thr | p.A124T | O95214 | protein_coding | deleterious_low_confidence(0.01) | benign(0.001) | TCGA-AG-A02N-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Chemotherapy | folinic | CR |
| LEPROTL1 | insertion | Frame_Shift_Ins | novel | c.117_118insT | p.Tyr42LeufsTer17 | p.Y42Lfs*17 | O95214 | protein_coding | TCGA-CM-6674-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
| LEPROTL1 | SNV | Missense_Mutation | novel | c.76N>A | p.Ala26Thr | p.A26T | O95214 | protein_coding | deleterious(0.02) | benign(0.306) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
| LEPROTL1 | SNV | Missense_Mutation | novel | c.470N>T | p.Ala157Val | p.A157V | O95214 | protein_coding | deleterious_low_confidence(0) | benign(0) | TCGA-EY-A1GK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| LEPROTL1 | insertion | Frame_Shift_Ins | novel | c.124dupT | p.Tyr42LeufsTer17 | p.Y42Lfs*17 | O95214 | protein_coding | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| LEPROTL1 | insertion | Frame_Shift_Ins | novel | c.92_92+1insCAAATACTGGCCCCTCTTT | p.Val38GlnfsTer27 | p.V38Qfs*27 | O95214 | protein_coding | TCGA-BB-A5HY-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
| Page: 1 2 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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