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Gene: LENG8 |
Gene summary for LENG8 |
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Gene information | Species | Human | Gene symbol | LENG8 | Gene ID | 114823 |
Gene name | leukocyte receptor cluster member 8 | |
Gene Alias | pp13842 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A0A024R4R9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114823 | LENG8 | LZE4T | Human | Esophagus | ESCC | 3.46e-06 | 1.68e-02 | 0.0811 |
114823 | LENG8 | LZE7T | Human | Esophagus | ESCC | 2.40e-07 | 4.10e-01 | 0.0667 |
114823 | LENG8 | LZE8T | Human | Esophagus | ESCC | 5.12e-08 | 3.00e-01 | 0.067 |
114823 | LENG8 | LZE20T | Human | Esophagus | ESCC | 1.76e-07 | 1.36e-01 | 0.0662 |
114823 | LENG8 | LZE22D1 | Human | Esophagus | HGIN | 2.52e-02 | 1.49e-01 | 0.0595 |
114823 | LENG8 | LZE24T | Human | Esophagus | ESCC | 5.24e-12 | 4.63e-01 | 0.0596 |
114823 | LENG8 | LZE21T | Human | Esophagus | ESCC | 1.71e-02 | 1.05e-01 | 0.0655 |
114823 | LENG8 | P1T-E | Human | Esophagus | ESCC | 2.52e-14 | 5.86e-01 | 0.0875 |
114823 | LENG8 | P2T-E | Human | Esophagus | ESCC | 2.79e-14 | 1.75e-01 | 0.1177 |
114823 | LENG8 | P4T-E | Human | Esophagus | ESCC | 3.17e-19 | 1.42e-01 | 0.1323 |
114823 | LENG8 | P5T-E | Human | Esophagus | ESCC | 1.34e-11 | 1.18e-01 | 0.1327 |
114823 | LENG8 | P8T-E | Human | Esophagus | ESCC | 1.45e-46 | 8.37e-01 | 0.0889 |
114823 | LENG8 | P9T-E | Human | Esophagus | ESCC | 5.91e-12 | 2.07e-01 | 0.1131 |
114823 | LENG8 | P10T-E | Human | Esophagus | ESCC | 7.94e-40 | 7.13e-01 | 0.116 |
114823 | LENG8 | P11T-E | Human | Esophagus | ESCC | 3.37e-06 | 5.16e-01 | 0.1426 |
114823 | LENG8 | P12T-E | Human | Esophagus | ESCC | 2.15e-22 | 2.73e-01 | 0.1122 |
114823 | LENG8 | P15T-E | Human | Esophagus | ESCC | 3.58e-16 | 2.61e-01 | 0.1149 |
114823 | LENG8 | P16T-E | Human | Esophagus | ESCC | 3.77e-14 | 9.62e-02 | 0.1153 |
114823 | LENG8 | P17T-E | Human | Esophagus | ESCC | 1.53e-02 | 4.10e-01 | 0.1278 |
114823 | LENG8 | P20T-E | Human | Esophagus | ESCC | 8.03e-26 | 5.85e-01 | 0.1124 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LENG8 | SNV | Missense_Mutation | novel | c.1561N>C | p.Ser521Pro | p.S521P | Q96PV6 | protein_coding | tolerated(0.06) | benign(0) | TCGA-AO-A0JD-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD |
LENG8 | SNV | Missense_Mutation | rs757513843 | c.2146C>T | p.Arg716Trp | p.R716W | Q96PV6 | protein_coding | deleterious(0) | benign(0.041) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
LENG8 | SNV | Missense_Mutation | c.1708N>G | p.Pro570Ala | p.P570A | Q96PV6 | protein_coding | tolerated(0.25) | possibly_damaging(0.747) | TCGA-C5-A1MK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
LENG8 | SNV | Missense_Mutation | novel | c.1228N>A | p.Asp410Asn | p.D410N | Q96PV6 | protein_coding | tolerated(0.25) | possibly_damaging(0.461) | TCGA-VS-A8QF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LENG8 | SNV | Missense_Mutation | novel | c.1516N>A | p.Glu506Lys | p.E506K | Q96PV6 | protein_coding | tolerated(0.08) | benign(0.202) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LENG8 | SNV | Missense_Mutation | novel | c.824N>C | p.Gly275Ala | p.G275A | Q96PV6 | protein_coding | tolerated(0.83) | benign(0) | TCGA-VS-A953-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
LENG8 | SNV | Missense_Mutation | rs147412771 | c.725N>A | p.Pro242His | p.P242H | Q96PV6 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VS-A9UO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LENG8 | SNV | Missense_Mutation | rs368841946 | c.533C>T | p.Thr178Met | p.T178M | Q96PV6 | protein_coding | deleterious_low_confidence(0.04) | benign(0.251) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
LENG8 | SNV | Missense_Mutation | rs749801525 | c.1034N>A | p.Arg345Gln | p.R345Q | Q96PV6 | protein_coding | tolerated(0.14) | benign(0.007) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LENG8 | SNV | Missense_Mutation | c.1388N>A | p.Arg463Gln | p.R463Q | Q96PV6 | protein_coding | deleterious(0.01) | possibly_damaging(0.818) | TCGA-A6-4107-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5 | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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