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Gene: LAYN |
Gene summary for LAYN |
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Gene information | Species | Human | Gene symbol | LAYN | Gene ID | 143903 |
Gene name | layilin | |
Gene Alias | LAYN | |
Cytomap | 11q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001726 | UniProtAcc | Q6UX15 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
143903 | LAYN | LZE4T | Human | Esophagus | ESCC | 3.78e-08 | 2.47e-01 | 0.0811 |
143903 | LAYN | LZE7T | Human | Esophagus | ESCC | 1.56e-14 | 7.58e-01 | 0.0667 |
143903 | LAYN | LZE20T | Human | Esophagus | ESCC | 7.18e-07 | 2.25e-01 | 0.0662 |
143903 | LAYN | LZE24T | Human | Esophagus | ESCC | 4.15e-02 | 1.74e-01 | 0.0596 |
143903 | LAYN | LZE21T | Human | Esophagus | ESCC | 1.37e-06 | 3.62e-01 | 0.0655 |
143903 | LAYN | P1T-E | Human | Esophagus | ESCC | 4.62e-03 | 1.61e-01 | 0.0875 |
143903 | LAYN | P2T-E | Human | Esophagus | ESCC | 4.44e-08 | 2.06e-01 | 0.1177 |
143903 | LAYN | P4T-E | Human | Esophagus | ESCC | 2.81e-13 | 4.82e-01 | 0.1323 |
143903 | LAYN | P5T-E | Human | Esophagus | ESCC | 7.32e-38 | 7.25e-01 | 0.1327 |
143903 | LAYN | P8T-E | Human | Esophagus | ESCC | 3.50e-02 | 8.82e-02 | 0.0889 |
143903 | LAYN | P9T-E | Human | Esophagus | ESCC | 7.05e-36 | 9.11e-01 | 0.1131 |
143903 | LAYN | P10T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.80e-01 | 0.116 |
143903 | LAYN | P11T-E | Human | Esophagus | ESCC | 9.92e-21 | 8.23e-01 | 0.1426 |
143903 | LAYN | P12T-E | Human | Esophagus | ESCC | 7.32e-38 | 6.78e-01 | 0.1122 |
143903 | LAYN | P15T-E | Human | Esophagus | ESCC | 3.26e-02 | 9.50e-02 | 0.1149 |
143903 | LAYN | P16T-E | Human | Esophagus | ESCC | 1.75e-25 | 4.59e-01 | 0.1153 |
143903 | LAYN | P20T-E | Human | Esophagus | ESCC | 4.83e-12 | 3.48e-01 | 0.1124 |
143903 | LAYN | P22T-E | Human | Esophagus | ESCC | 6.62e-20 | 3.57e-01 | 0.1236 |
143903 | LAYN | P23T-E | Human | Esophagus | ESCC | 4.97e-06 | 2.52e-01 | 0.108 |
143903 | LAYN | P24T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.49e-01 | 0.1287 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAYN | SNV | Missense_Mutation | rs768697237 | c.490N>A | p.Gly164Arg | p.G164R | Q6UX15 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LAYN | SNV | Missense_Mutation | c.220N>A | p.Asp74Asn | p.D74N | Q6UX15 | protein_coding | tolerated(0.05) | benign(0.19) | TCGA-AO-A0J4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
LAYN | SNV | Missense_Mutation | novel | c.179N>A | p.Arg60Gln | p.R60Q | Q6UX15 | protein_coding | tolerated(0.11) | benign(0.013) | TCGA-C8-A137-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LAYN | SNV | Missense_Mutation | novel | c.442N>C | p.Glu148Gln | p.E148Q | Q6UX15 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-C5-A905-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LAYN | SNV | Missense_Mutation | novel | c.601N>A | p.Glu201Lys | p.E201K | Q6UX15 | protein_coding | tolerated(0.61) | benign(0.014) | TCGA-ZJ-AAXA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LAYN | SNV | Missense_Mutation | novel | c.995N>C | p.Asp332Ala | p.D332A | Q6UX15 | protein_coding | deleterious(0) | benign(0.255) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LAYN | SNV | Missense_Mutation | c.640A>G | p.Thr214Ala | p.T214A | Q6UX15 | protein_coding | tolerated(0.61) | benign(0) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
LAYN | SNV | Missense_Mutation | rs773587902 | c.790N>T | p.Arg264Trp | p.R264W | Q6UX15 | protein_coding | deleterious(0.02) | possibly_damaging(0.549) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LAYN | SNV | Missense_Mutation | novel | c.155T>G | p.Val52Gly | p.V52G | Q6UX15 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LAYN | SNV | Missense_Mutation | novel | c.363C>G | p.Cys121Trp | p.C121W | Q6UX15 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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