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Gene: LAMTOR4 |
Gene summary for LAMTOR4 |
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Gene information | Species | Human | Gene symbol | LAMTOR4 | Gene ID | 389541 |
Gene name | late endosomal/lysosomal adaptor, MAPK and MTOR activator 4 | |
Gene Alias | C7orf59 | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001101 | UniProtAcc | Q0VGL1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389541 | LAMTOR4 | CA_HPV_1 | Human | Cervix | CC | 1.38e-08 | -2.33e-01 | 0.0264 |
389541 | LAMTOR4 | CA_HPV_3 | Human | Cervix | CC | 1.07e-03 | 9.05e-02 | 0.0414 |
389541 | LAMTOR4 | CCI_1 | Human | Cervix | CC | 1.28e-07 | -6.86e-01 | 0.528 |
389541 | LAMTOR4 | CCI_2 | Human | Cervix | CC | 3.01e-02 | -4.93e-01 | 0.5249 |
389541 | LAMTOR4 | CCI_3 | Human | Cervix | CC | 1.27e-10 | -7.04e-01 | 0.516 |
389541 | LAMTOR4 | CCII_1 | Human | Cervix | CC | 5.94e-28 | -8.74e-01 | 0.3249 |
389541 | LAMTOR4 | Tumor | Human | Cervix | CC | 1.60e-02 | -2.19e-01 | 0.1241 |
389541 | LAMTOR4 | sample3 | Human | Cervix | CC | 3.05e-09 | -2.51e-01 | 0.1387 |
389541 | LAMTOR4 | H2 | Human | Cervix | HSIL_HPV | 3.54e-09 | -4.20e-01 | 0.0632 |
389541 | LAMTOR4 | L1 | Human | Cervix | CC | 1.12e-12 | -2.95e-01 | 0.0802 |
389541 | LAMTOR4 | T1 | Human | Cervix | CC | 5.44e-04 | -3.71e-01 | 0.0918 |
389541 | LAMTOR4 | T3 | Human | Cervix | CC | 4.31e-10 | -2.71e-01 | 0.1389 |
389541 | LAMTOR4 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.95e-10 | 1.94e-01 | 0.0155 |
389541 | LAMTOR4 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.69e-05 | 4.68e-01 | -0.1808 |
389541 | LAMTOR4 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.21e-19 | 6.59e-01 | -0.1954 |
389541 | LAMTOR4 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.34e-02 | 8.38e-01 | -0.2602 |
389541 | LAMTOR4 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.62e-04 | 5.12e-01 | -0.1207 |
389541 | LAMTOR4 | HTA11_696_2000001011 | Human | Colorectum | AD | 5.64e-16 | 5.46e-01 | -0.1464 |
389541 | LAMTOR4 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.97e-06 | 3.26e-01 | -0.1001 |
389541 | LAMTOR4 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.12e-07 | 5.33e-01 | -0.059 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:00726655 | Cervix | CC | protein localization to vacuole | 20/2311 | 67/18723 | 1.12e-04 | 1.40e-03 | 20 |
GO:00011016 | Cervix | CC | response to acid chemical | 31/2311 | 135/18723 | 4.16e-04 | 4.22e-03 | 31 |
GO:00712292 | Cervix | CC | cellular response to acid chemical | 20/2311 | 80/18723 | 1.40e-03 | 1.10e-02 | 20 |
GO:00712301 | Cervix | CC | cellular response to amino acid stimulus | 18/2311 | 71/18723 | 2.01e-03 | 1.47e-02 | 18 |
GO:00614623 | Cervix | CC | protein localization to lysosome | 13/2311 | 46/18723 | 2.95e-03 | 1.94e-02 | 13 |
GO:00432004 | Cervix | CC | response to amino acid | 25/2311 | 116/18723 | 3.59e-03 | 2.30e-02 | 25 |
GO:003253515 | Cervix | HSIL_HPV | regulation of cellular component size | 27/737 | 383/18723 | 2.63e-03 | 2.54e-02 | 27 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:0072665 | Colorectum | AD | protein localization to vacuole | 27/3918 | 67/18723 | 2.40e-04 | 3.04e-03 | 27 |
GO:0008361 | Colorectum | AD | regulation of cell size | 56/3918 | 181/18723 | 9.61e-04 | 9.07e-03 | 56 |
GO:0061462 | Colorectum | AD | protein localization to lysosome | 19/3918 | 46/18723 | 1.36e-03 | 1.19e-02 | 19 |
GO:00325351 | Colorectum | SER | regulation of cellular component size | 115/2897 | 383/18723 | 3.04e-13 | 1.10e-10 | 115 |
GO:00726651 | Colorectum | SER | protein localization to vacuole | 19/2897 | 67/18723 | 5.14e-03 | 3.93e-02 | 19 |
GO:00325352 | Colorectum | MSS | regulation of cellular component size | 127/3467 | 383/18723 | 3.44e-12 | 5.79e-10 | 127 |
GO:00726652 | Colorectum | MSS | protein localization to vacuole | 23/3467 | 67/18723 | 1.51e-03 | 1.39e-02 | 23 |
GO:00083611 | Colorectum | MSS | regulation of cell size | 50/3467 | 181/18723 | 1.65e-03 | 1.49e-02 | 50 |
GO:0031929 | Colorectum | MSS | TOR signaling | 35/3467 | 126/18723 | 6.91e-03 | 4.44e-02 | 35 |
GO:003253510 | Endometrium | AEH | regulation of cellular component size | 78/2100 | 383/18723 | 1.10e-07 | 5.29e-06 | 78 |
GO:00083616 | Endometrium | AEH | regulation of cell size | 38/2100 | 181/18723 | 9.69e-05 | 1.40e-03 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04150 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041501 | Colorectum | MSS | mTOR signaling pathway | 47/1875 | 156/8465 | 1.19e-02 | 3.99e-02 | 2.44e-02 | 47 |
hsa041505 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa0415013 | Esophagus | ESCC | mTOR signaling pathway | 98/4205 | 156/8465 | 5.81e-04 | 1.95e-03 | 9.97e-04 | 98 |
hsa041502 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa0415011 | Liver | HCC | mTOR signaling pathway | 95/4020 | 156/8465 | 4.70e-04 | 1.99e-03 | 1.11e-03 | 95 |
hsa041504 | Oral cavity | OSCC | mTOR signaling pathway | 90/3704 | 156/8465 | 2.87e-04 | 9.15e-04 | 4.66e-04 | 90 |
hsa0415012 | Oral cavity | OSCC | mTOR signaling pathway | 90/3704 | 156/8465 | 2.87e-04 | 9.15e-04 | 4.66e-04 | 90 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAMTOR4 | SNV | Missense_Mutation | c.49N>C | p.Gly17Arg | p.G17R | Q0VGL1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A2LX-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | |
LAMTOR4 | SNV | Missense_Mutation | novel | c.194N>A | p.Arg65His | p.R65H | Q0VGL1 | protein_coding | tolerated(0.06) | benign(0.067) | TCGA-VS-A8EJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
LAMTOR4 | SNV | Missense_Mutation | novel | c.287N>T | p.Pro96Leu | p.P96L | Q0VGL1 | protein_coding | tolerated(0.06) | probably_damaging(0.998) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
LAMTOR4 | SNV | Missense_Mutation | c.76N>T | p.Val26Leu | p.V26L | Q0VGL1 | protein_coding | deleterious(0.03) | benign(0.269) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LAMTOR4 | SNV | Missense_Mutation | novel | c.203N>G | p.Val68Gly | p.V68G | Q0VGL1 | protein_coding | deleterious(0.01) | benign(0.022) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
LAMTOR4 | SNV | Missense_Mutation | c.248N>T | p.Arg83Met | p.R83M | Q0VGL1 | protein_coding | deleterious(0) | benign(0.416) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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