Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: LAMB4

Gene summary for LAMB4

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

LAMB4

Gene ID

22798

Gene namelaminin subunit beta 4
Gene AliasLAMB4
Cytomap7q31.1
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

A4D0S4


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
22798LAMB4P4_S8_cSCCHumanSkincSCC2.20e-387.42e-01-0.3095
22798LAMB4P1_cSCCHumanSkincSCC1.06e-155.97e-010.0292
22798LAMB4P2_cSCCHumanSkincSCC2.43e-062.45e-01-0.024
22798LAMB4P4_cSCCHumanSkincSCC1.75e-052.13e-01-0.00290000000000005
22798LAMB4cSCC_p1HumanSkincSCC1.87e-063.05e-01-0.1916
22798LAMB4cSCC_p11HumanSkincSCC9.03e-083.29e-01-0.2102
22798LAMB4cSCC_p4HumanSkincSCC6.75e-133.60e-01-0.2022
22798LAMB4cSCC_p6HumanSkincSCC2.27e-052.23e-01-0.1989
22798LAMB4cSCC_p7HumanSkincSCC1.85e-022.76e-01-0.2332
22798LAMB4cSCC_p8HumanSkincSCC4.01e-102.40e-01-0.1971
22798LAMB4cSCC_p9HumanSkincSCC1.99e-112.52e-01-0.1991
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:003158926SkincSCCcell-substrate adhesion130/4864363/187231.87e-052.23e-04130
GO:0034446110SkincSCCsubstrate adhesion-dependent cell spreading43/4864108/187231.12e-037.36e-0343
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
LAMB4SNVMissense_Mutationrs746002204c.2077N>Ap.Pro693Thrp.P693TA4D0S4protein_codingtolerated(0.26)benign(0.03)TCGA-A8-A076-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyanastrozoleSD
LAMB4SNVMissense_Mutationnovelc.3859N>Ap.Glu1287Lysp.E1287KA4D0S4protein_codingtolerated(0.1)benign(0.012)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
LAMB4SNVMissense_Mutationrs754196717c.2098G>Ap.Ala700Thrp.A700TA4D0S4protein_codingtolerated(0.33)benign(0.003)TCGA-AC-A3W5-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydocetaxelCR
LAMB4SNVMissense_Mutationnovelc.3811C>Ap.Leu1271Metp.L1271MA4D0S4protein_codingdeleterious(0.03)possibly_damaging(0.831)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
LAMB4SNVMissense_Mutationc.4228N>Ap.Gly1410Serp.G1410SA4D0S4protein_codingdeleterious(0.03)benign(0.025)TCGA-BH-A0DL-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanCR
LAMB4SNVMissense_Mutationnovelc.3452A>Gp.Glu1151Glyp.E1151GA4D0S4protein_codingtolerated(0.24)benign(0.192)TCGA-BH-A5J0-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
LAMB4SNVMissense_Mutationc.847N>Cp.Asp283Hisp.D283HA4D0S4protein_codingdeleterious(0)probably_damaging(1)TCGA-C8-A26Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
LAMB4SNVMissense_Mutationc.5135N>Ap.Arg1712Lysp.R1712KA4D0S4protein_codingtolerated(0.8)benign(0.012)TCGA-C8-A275-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
LAMB4SNVMissense_Mutationnovelc.2674N>Ap.Glu892Lysp.E892KA4D0S4protein_codingdeleterious(0)probably_damaging(0.947)TCGA-C8-A3M7-01Breastbreast invasive carcinomaFemale<65III/IVUnknownUnknownPD
LAMB4SNVMissense_Mutationnovelc.4597G>Ap.Glu1533Lysp.E1533KA4D0S4protein_codingdeleterious(0.02)possibly_damaging(0.508)TCGA-C8-A8HP-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapy5-fluorouracilCR
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
22798LAMB4DRUGGABLE GENOMECHEMBL2095222OCRIPLASMIN
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