![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LAMB4 |
Gene summary for LAMB4 |
![]() |
Gene information | Species | Human | Gene symbol | LAMB4 | Gene ID | 22798 |
Gene name | laminin subunit beta 4 | |
Gene Alias | LAMB4 | |
Cytomap | 7q31.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | A4D0S4 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22798 | LAMB4 | P4_S8_cSCC | Human | Skin | cSCC | 2.20e-38 | 7.42e-01 | -0.3095 |
22798 | LAMB4 | P1_cSCC | Human | Skin | cSCC | 1.06e-15 | 5.97e-01 | 0.0292 |
22798 | LAMB4 | P2_cSCC | Human | Skin | cSCC | 2.43e-06 | 2.45e-01 | -0.024 |
22798 | LAMB4 | P4_cSCC | Human | Skin | cSCC | 1.75e-05 | 2.13e-01 | -0.00290000000000005 |
22798 | LAMB4 | cSCC_p1 | Human | Skin | cSCC | 1.87e-06 | 3.05e-01 | -0.1916 |
22798 | LAMB4 | cSCC_p11 | Human | Skin | cSCC | 9.03e-08 | 3.29e-01 | -0.2102 |
22798 | LAMB4 | cSCC_p4 | Human | Skin | cSCC | 6.75e-13 | 3.60e-01 | -0.2022 |
22798 | LAMB4 | cSCC_p6 | Human | Skin | cSCC | 2.27e-05 | 2.23e-01 | -0.1989 |
22798 | LAMB4 | cSCC_p7 | Human | Skin | cSCC | 1.85e-02 | 2.76e-01 | -0.2332 |
22798 | LAMB4 | cSCC_p8 | Human | Skin | cSCC | 4.01e-10 | 2.40e-01 | -0.1971 |
22798 | LAMB4 | cSCC_p9 | Human | Skin | cSCC | 1.99e-11 | 2.52e-01 | -0.1991 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Skin | ![]() | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma | ||
SCCIS:squamous cell carcinoma in situ |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003158926 | Skin | cSCC | cell-substrate adhesion | 130/4864 | 363/18723 | 1.87e-05 | 2.23e-04 | 130 |
GO:0034446110 | Skin | cSCC | substrate adhesion-dependent cell spreading | 43/4864 | 108/18723 | 1.12e-03 | 7.36e-03 | 43 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LAMB4 | SNV | Missense_Mutation | rs746002204 | c.2077N>A | p.Pro693Thr | p.P693T | A4D0S4 | protein_coding | tolerated(0.26) | benign(0.03) | TCGA-A8-A076-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | SD |
LAMB4 | SNV | Missense_Mutation | novel | c.3859N>A | p.Glu1287Lys | p.E1287K | A4D0S4 | protein_coding | tolerated(0.1) | benign(0.012) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
LAMB4 | SNV | Missense_Mutation | rs754196717 | c.2098G>A | p.Ala700Thr | p.A700T | A4D0S4 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-AC-A3W5-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
LAMB4 | SNV | Missense_Mutation | novel | c.3811C>A | p.Leu1271Met | p.L1271M | A4D0S4 | protein_coding | deleterious(0.03) | possibly_damaging(0.831) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LAMB4 | SNV | Missense_Mutation | c.4228N>A | p.Gly1410Ser | p.G1410S | A4D0S4 | protein_coding | deleterious(0.03) | benign(0.025) | TCGA-BH-A0DL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
LAMB4 | SNV | Missense_Mutation | novel | c.3452A>G | p.Glu1151Gly | p.E1151G | A4D0S4 | protein_coding | tolerated(0.24) | benign(0.192) | TCGA-BH-A5J0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LAMB4 | SNV | Missense_Mutation | c.847N>C | p.Asp283His | p.D283H | A4D0S4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A26Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LAMB4 | SNV | Missense_Mutation | c.5135N>A | p.Arg1712Lys | p.R1712K | A4D0S4 | protein_coding | tolerated(0.8) | benign(0.012) | TCGA-C8-A275-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LAMB4 | SNV | Missense_Mutation | novel | c.2674N>A | p.Glu892Lys | p.E892K | A4D0S4 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-C8-A3M7-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
LAMB4 | SNV | Missense_Mutation | novel | c.4597G>A | p.Glu1533Lys | p.E1533K | A4D0S4 | protein_coding | deleterious(0.02) | possibly_damaging(0.508) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
22798 | LAMB4 | DRUGGABLE GENOME | CHEMBL2095222 | OCRIPLASMIN |
Page: 1 |