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Gene: L1TD1 |
Gene summary for L1TD1 |
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Gene information | Species | Human | Gene symbol | L1TD1 | Gene ID | 54596 |
Gene name | LINE1 type transposase domain containing 1 | |
Gene Alias | ECAT11 | |
Cytomap | 1p31.3 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q5T7N2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54596 | L1TD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.21e-02 | 7.76e-02 | 0.0155 |
54596 | L1TD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.97e-04 | -4.39e-01 | -0.1808 |
54596 | L1TD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 5.86e-07 | -4.05e-01 | -0.1954 |
54596 | L1TD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.59e-02 | -5.76e-01 | -0.2061 |
54596 | L1TD1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.15e-02 | 7.94e-01 | 0.0131 |
54596 | L1TD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.85e-09 | 6.35e-01 | 0.0674 |
54596 | L1TD1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.61e-02 | -4.56e-01 | 0.0588 |
54596 | L1TD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.58e-04 | 3.83e-01 | 0.294 |
54596 | L1TD1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.93e-09 | -5.88e-01 | 0.281 |
54596 | L1TD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.93e-21 | -6.01e-01 | 0.3859 |
54596 | L1TD1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.16e-02 | -4.61e-01 | 0.2585 |
54596 | L1TD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 2.17e-24 | -6.01e-01 | 0.3005 |
54596 | L1TD1 | A015-C-203 | Human | Colorectum | FAP | 1.28e-08 | 1.94e-01 | -0.1294 |
54596 | L1TD1 | A002-C-201 | Human | Colorectum | FAP | 5.58e-14 | 6.82e-01 | 0.0324 |
54596 | L1TD1 | A002-C-205 | Human | Colorectum | FAP | 4.72e-12 | 4.15e-01 | -0.1236 |
54596 | L1TD1 | A015-C-005 | Human | Colorectum | FAP | 2.05e-04 | -3.39e-01 | -0.0336 |
54596 | L1TD1 | A015-C-006 | Human | Colorectum | FAP | 2.33e-07 | 3.59e-01 | -0.0994 |
54596 | L1TD1 | A015-C-106 | Human | Colorectum | FAP | 2.47e-05 | -3.24e-01 | -0.0511 |
54596 | L1TD1 | A002-C-114 | Human | Colorectum | FAP | 7.01e-20 | 7.52e-01 | -0.1561 |
54596 | L1TD1 | A015-C-104 | Human | Colorectum | FAP | 4.47e-07 | 8.29e-02 | -0.1899 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
L1TD1 | SNV | Missense_Mutation | c.176N>A | p.Met59Lys | p.M59K | Q5T7N2 | protein_coding | tolerated(0.12) | benign(0.284) | TCGA-BH-A0HA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
L1TD1 | SNV | Missense_Mutation | novel | c.1378N>T | p.Ile460Leu | p.I460L | Q5T7N2 | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-BH-A8FY-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
L1TD1 | SNV | Missense_Mutation | c.20N>T | p.Ser7Ile | p.S7I | Q5T7N2 | protein_coding | deleterious(0.04) | benign(0.006) | TCGA-D8-A1XJ-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | tamoxiphen | SD | |
L1TD1 | SNV | Missense_Mutation | c.907N>T | p.Ala303Ser | p.A303S | Q5T7N2 | protein_coding | tolerated(0.12) | benign(0.157) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
L1TD1 | SNV | Missense_Mutation | novel | c.11T>C | p.Val4Ala | p.V4A | Q5T7N2 | protein_coding | tolerated_low_confidence(0.06) | benign(0.006) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
L1TD1 | SNV | Missense_Mutation | c.245N>C | p.Gly82Ala | p.G82A | Q5T7N2 | protein_coding | tolerated(1) | benign(0.026) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
L1TD1 | SNV | Missense_Mutation | novel | c.1113N>A | p.Met371Ile | p.M371I | Q5T7N2 | protein_coding | tolerated(0.22) | benign(0) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
L1TD1 | SNV | Missense_Mutation | novel | c.358G>A | p.Glu120Lys | p.E120K | Q5T7N2 | protein_coding | deleterious(0.03) | probably_damaging(0.986) | TCGA-MY-A913-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
L1TD1 | SNV | Missense_Mutation | novel | c.1682N>T | p.Ser561Leu | p.S561L | Q5T7N2 | protein_coding | deleterious(0) | possibly_damaging(0.676) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
L1TD1 | SNV | Missense_Mutation | c.256N>G | p.Thr86Ala | p.T86A | Q5T7N2 | protein_coding | tolerated(0.34) | benign(0.003) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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