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Gene: KRTAP3-1 |
Gene summary for KRTAP3-1 |
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Gene information | Species | Human | Gene symbol | KRTAP3-1 | Gene ID | 83896 |
Gene name | keratin associated protein 3-1 | |
Gene Alias | KAP3.1 | |
Cytomap | 17q21.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BYR8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83896 | KRTAP3-1 | P4T-E | Human | Esophagus | ESCC | 1.32e-23 | 2.11e+00 | 0.1323 |
83896 | KRTAP3-1 | P5T-E | Human | Esophagus | ESCC | 5.00e-13 | 2.03e+00 | 0.1327 |
83896 | KRTAP3-1 | P8T-E | Human | Esophagus | ESCC | 1.08e-15 | 9.59e-01 | 0.0889 |
83896 | KRTAP3-1 | P12T-E | Human | Esophagus | ESCC | 3.87e-02 | 2.69e-01 | 0.1122 |
83896 | KRTAP3-1 | P15T-E | Human | Esophagus | ESCC | 5.26e-03 | 3.15e-01 | 0.1149 |
83896 | KRTAP3-1 | P26T-E | Human | Esophagus | ESCC | 3.62e-18 | 1.34e+00 | 0.1276 |
83896 | KRTAP3-1 | P61T-E | Human | Esophagus | ESCC | 2.66e-21 | 8.57e-01 | 0.099 |
83896 | KRTAP3-1 | P62T-E | Human | Esophagus | ESCC | 2.13e-09 | 8.76e-01 | 0.1302 |
83896 | KRTAP3-1 | P65T-E | Human | Esophagus | ESCC | 1.06e-02 | 1.35e-01 | 0.0978 |
83896 | KRTAP3-1 | P80T-E | Human | Esophagus | ESCC | 7.90e-04 | 4.26e-01 | 0.155 |
83896 | KRTAP3-1 | P130T-E | Human | Esophagus | ESCC | 9.17e-10 | 2.35e+00 | 0.1676 |
83896 | KRTAP3-1 | GSM5252130_BPH340PrGF_Via | Human | Prostate | BPH | 1.05e-06 | 1.72e+00 | -0.1972 |
83896 | KRTAP3-1 | GSM5252134_BPH511PrG_Fcol_3GEX | Human | Prostate | BPH | 4.94e-02 | 2.21e+00 | -0.1433 |
83896 | KRTAP3-1 | GSM5252136_BPH556PrGA1_Fcol | Human | Prostate | BPH | 3.86e-07 | 1.92e+00 | -0.23 |
83896 | KRTAP3-1 | 048752_1579-all-cells | Human | Prostate | BPH | 2.33e-07 | -3.93e-01 | 0.1008 |
83896 | KRTAP3-1 | 052095_1628-all-cells | Human | Prostate | BPH | 2.32e-04 | -4.15e-01 | 0.1032 |
83896 | KRTAP3-1 | Dong_P1 | Human | Prostate | Tumor | 7.50e-10 | -4.14e-01 | 0.035 |
83896 | KRTAP3-1 | Dong_P5 | Human | Prostate | Tumor | 3.07e-08 | -4.88e-01 | 0.053 |
83896 | KRTAP3-1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 2.18e-03 | -5.70e-01 | 0.1633 |
83896 | KRTAP3-1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 7.46e-06 | -5.70e-01 | 0.1608 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRTAP3-1 | SNV | Missense_Mutation | rs370223389 | c.218N>T | p.Pro73Leu | p.P73L | Q9BYR8 | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.999) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
KRTAP3-1 | SNV | Missense_Mutation | c.236N>T | p.Gly79Val | p.G79V | Q9BYR8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KRTAP3-1 | SNV | Missense_Mutation | rs753535111 | c.83G>A | p.Cys28Tyr | p.C28Y | Q9BYR8 | protein_coding | tolerated_low_confidence(0.07) | benign(0.191) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
KRTAP3-1 | SNV | Missense_Mutation | novel | c.4N>C | p.Tyr2His | p.Y2H | Q9BYR8 | protein_coding | tolerated_low_confidence(0.13) | benign(0.003) | TCGA-AJ-A3NE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRTAP3-1 | SNV | Missense_Mutation | c.124N>A | p.Leu42Ile | p.L42I | Q9BYR8 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.992) | TCGA-AP-A05O-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | |
KRTAP3-1 | SNV | Missense_Mutation | novel | c.74N>A | p.Ser25Asn | p.S25N | Q9BYR8 | protein_coding | deleterious_low_confidence(0.05) | benign(0.303) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRTAP3-1 | SNV | Missense_Mutation | novel | c.194N>C | p.Cys65Ser | p.C65S | Q9BYR8 | protein_coding | tolerated_low_confidence(0.07) | probably_damaging(0.991) | TCGA-44-2659-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | alimta | PD |
KRTAP3-1 | SNV | Missense_Mutation | c.236N>C | p.Gly79Ala | p.G79A | Q9BYR8 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.999) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KRTAP3-1 | SNV | Missense_Mutation | rs141325742 | c.20N>A | p.Arg7His | p.R7H | Q9BYR8 | protein_coding | tolerated_low_confidence(0.19) | benign(0.288) | TCGA-HC-7818-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD |
KRTAP3-1 | SNV | Missense_Mutation | novel | c.149N>T | p.Thr50Ile | p.T50I | Q9BYR8 | protein_coding | tolerated_low_confidence(0.15) | benign(0.042) | TCGA-BR-A4J2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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