Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KRT20

Gene summary for KRT20

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KRT20

Gene ID

54474

Gene namekeratin 20
Gene AliasCD20
Cytomap17q21.2
Gene Typeprotein-coding
GO ID

GO:0006810

UniProtAcc

P35900


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
54474KRT20HTA11_3410_2000001011HumanColorectumAD1.74e-03-2.19e-010.0155
54474KRT20HTA11_2487_2000001011HumanColorectumSER8.71e-172.00e+00-0.1808
54474KRT20HTA11_1938_2000001011HumanColorectumAD4.96e-099.15e-01-0.0811
54474KRT20HTA11_78_2000001011HumanColorectumAD6.56e-111.32e+00-0.1088
54474KRT20HTA11_347_2000001011HumanColorectumAD2.82e-101.46e+00-0.1954
54474KRT20HTA11_411_2000001011HumanColorectumSER1.39e-052.48e+00-0.2602
54474KRT20HTA11_2112_2000001011HumanColorectumSER3.32e-082.13e+00-0.2196
54474KRT20HTA11_83_2000001011HumanColorectumSER1.42e-111.71e+00-0.1526
54474KRT20HTA11_696_2000001011HumanColorectumAD9.60e-161.29e+00-0.1464
54474KRT20HTA11_1391_2000001011HumanColorectumAD1.94e-078.02e-01-0.059
54474KRT20HTA11_2992_2000001011HumanColorectumSER1.01e-051.73e+00-0.1706
54474KRT20HTA11_5212_2000001011HumanColorectumAD1.45e-092.16e+00-0.2061
54474KRT20HTA11_7696_3000711011HumanColorectumAD4.01e-02-1.70e-010.0674
54474KRT20HTA11_99999971662_82457HumanColorectumMSS1.72e-06-2.11e-010.3859
54474KRT20A002-C-010HumanColorectumFAP4.15e-03-1.75e-010.242
54474KRT20A015-C-203HumanColorectumFAP8.48e-03-1.02e-01-0.1294
54474KRT20A002-C-203HumanColorectumFAP1.80e-03-1.59e-010.2786
54474KRT20A002-C-205HumanColorectumFAP1.63e-02-1.77e-01-0.1236
54474KRT20A015-C-106HumanColorectumFAP3.91e-02-1.44e-01-0.0511
54474KRT20A002-C-114HumanColorectumFAP1.86e-02-1.98e-01-0.1561
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0031667ColorectumADresponse to nutrient levels138/3918474/187231.22e-052.68e-04138
GO:0050708ColorectumADregulation of protein secretion83/3918268/187236.59e-051.07e-0383
GO:0009306ColorectumADprotein secretion105/3918359/187231.05e-041.57e-03105
GO:0035592ColorectumADestablishment of protein localization to extracellular region105/3918360/187231.18e-041.73e-03105
GO:0042594ColorectumADresponse to starvation63/3918197/187231.77e-042.38e-0363
GO:0071692ColorectumADprotein localization to extracellular region106/3918368/187231.86e-042.49e-03106
GO:0071496ColorectumADcellular response to external stimulus94/3918320/187231.98e-042.64e-0394
GO:0009267ColorectumADcellular response to starvation51/3918156/187233.90e-044.44e-0351
GO:0031668ColorectumADcellular response to extracellular stimulus71/3918246/187231.86e-031.52e-0271
GO:0031669ColorectumADcellular response to nutrient levels63/3918215/187232.19e-031.73e-0263
GO:00316671ColorectumSERresponse to nutrient levels106/2897474/187233.94e-051.00e-03106
GO:00507081ColorectumSERregulation of protein secretion63/2897268/187233.42e-045.39e-0363
GO:00093061ColorectumSERprotein secretion79/2897359/187235.99e-048.19e-0379
GO:00355921ColorectumSERestablishment of protein localization to extracellular region79/2897360/187236.54e-048.77e-0379
GO:00716921ColorectumSERprotein localization to extracellular region80/2897368/187238.13e-041.01e-0280
GO:00425941ColorectumSERresponse to starvation47/2897197/187231.31e-031.45e-0247
GO:00714961ColorectumSERcellular response to external stimulus70/2897320/187231.40e-031.53e-0270
GO:00092671ColorectumSERcellular response to starvation38/2897156/187232.45e-032.32e-0238
GO:00316681ColorectumSERcellular response to extracellular stimulus54/2897246/187234.26e-033.45e-0254
GO:00316691ColorectumSERcellular response to nutrient levels48/2897215/187234.82e-033.78e-0248
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa04915ColorectumSEREstrogen signaling pathway38/1580138/84656.51e-033.68e-022.67e-0238
hsa049151ColorectumSEREstrogen signaling pathway38/1580138/84656.51e-033.68e-022.67e-0238
hsa049152ColorectumMSSEstrogen signaling pathway48/1875138/84654.23e-043.08e-031.89e-0348
hsa049153ColorectumMSSEstrogen signaling pathway48/1875138/84654.23e-043.08e-031.89e-0348
hsa0491512StomachGCEstrogen signaling pathway23/708138/84651.02e-037.44e-035.23e-0323
hsa0491513StomachGCEstrogen signaling pathway23/708138/84651.02e-037.44e-035.23e-0323
hsa0491521StomachCAG with IMEstrogen signaling pathway21/640138/84651.53e-031.01e-027.10e-0321
hsa0491531StomachCAG with IMEstrogen signaling pathway21/640138/84651.53e-031.01e-027.10e-0321
hsa049158StomachWIMEstrogen signaling pathway16/284138/84651.41e-051.72e-041.37e-0416
hsa049159StomachWIMEstrogen signaling pathway16/284138/84651.41e-051.72e-041.37e-0416
hsa0491510StomachSIMEstrogen signaling pathway20/465138/84655.98e-056.73e-045.40e-0420
hsa0491511StomachSIMEstrogen signaling pathway20/465138/84655.98e-056.73e-045.40e-0420
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KRT20SNVMissense_Mutationnovelc.484N>Ap.Glu162Lysp.E162KP35900protein_codingdeleterious(0)probably_damaging(0.912)TCGA-A2-A0YD-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
KRT20SNVMissense_Mutationc.245N>Tp.Ala82Valp.A82VP35900protein_codingdeleterious(0)probably_damaging(1)TCGA-AN-A0AK-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KRT20SNVMissense_Mutationc.1010N>Ap.Ala337Aspp.A337DP35900protein_codingtolerated(0.14)benign(0.011)TCGA-D8-A1JL-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KRT20insertionFrame_Shift_Insrs747468237c.73_74insCTGTTTATATAGGAAGGGGTp.Gly25AlafsTer36p.G25Afs*36P35900protein_codingTCGA-A2-A0CU-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
KRT20insertionFrame_Shift_Insrs747468237c.73_74insCTGTTTATATAGGAAGGGGTp.Gly25AlafsTer36p.G25Afs*36P35900protein_codingTCGA-A8-A08H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KRT20insertionFrame_Shift_Insnovelc.724_727dupATGAp.Arg243AsnfsTer6p.R243Nfs*6P35900protein_codingTCGA-BH-A0AV-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
KRT20SNVMissense_Mutationrs754776993c.118G>Ap.Gly40Argp.G40RP35900protein_codingdeleterious(0)probably_damaging(0.999)TCGA-IR-A3LH-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KRT20SNVMissense_Mutationc.373N>Ap.Glu125Lysp.E125KP35900protein_codingtolerated(0.08)benign(0.018)TCGA-Q1-A73O-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KRT20SNVMissense_Mutationc.643N>Ap.Leu215Ilep.L215IP35900protein_codingdeleterious(0.03)probably_damaging(0.998)TCGA-AA-3492-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
KRT20SNVMissense_Mutationrs371817674c.1210N>Ap.Val404Metp.V404MP35900protein_codingtolerated(0.05)probably_damaging(0.998)TCGA-CM-6674-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
54474KRT20NACISPLATINCISPLATIN15017198
54474KRT20NADOXORUBICIN HYDROCHLORIDE15017198
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