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Gene: KRBOX4 |
Gene summary for KRBOX4 |
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Gene information | Species | Human | Gene symbol | KRBOX4 | Gene ID | 55634 |
Gene name | KRAB box domain containing 4 | |
Gene Alias | ZNF673 | |
Cytomap | Xp11.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5JUW0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55634 | KRBOX4 | LZE4T | Human | Esophagus | ESCC | 1.44e-07 | 2.52e-01 | 0.0811 |
55634 | KRBOX4 | LZE7T | Human | Esophagus | ESCC | 1.53e-07 | 3.13e-01 | 0.0667 |
55634 | KRBOX4 | LZE24T | Human | Esophagus | ESCC | 5.19e-05 | 1.33e-01 | 0.0596 |
55634 | KRBOX4 | P1T-E | Human | Esophagus | ESCC | 2.33e-04 | 2.03e-01 | 0.0875 |
55634 | KRBOX4 | P2T-E | Human | Esophagus | ESCC | 2.39e-24 | 3.64e-01 | 0.1177 |
55634 | KRBOX4 | P4T-E | Human | Esophagus | ESCC | 4.02e-14 | 2.29e-01 | 0.1323 |
55634 | KRBOX4 | P5T-E | Human | Esophagus | ESCC | 1.59e-30 | 4.34e-01 | 0.1327 |
55634 | KRBOX4 | P8T-E | Human | Esophagus | ESCC | 5.79e-16 | 2.48e-01 | 0.0889 |
55634 | KRBOX4 | P9T-E | Human | Esophagus | ESCC | 1.13e-09 | 1.96e-01 | 0.1131 |
55634 | KRBOX4 | P10T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.02e-01 | 0.116 |
55634 | KRBOX4 | P11T-E | Human | Esophagus | ESCC | 7.64e-10 | 3.64e-01 | 0.1426 |
55634 | KRBOX4 | P12T-E | Human | Esophagus | ESCC | 9.02e-11 | 1.83e-01 | 0.1122 |
55634 | KRBOX4 | P15T-E | Human | Esophagus | ESCC | 8.18e-10 | 1.65e-01 | 0.1149 |
55634 | KRBOX4 | P16T-E | Human | Esophagus | ESCC | 1.59e-30 | 4.02e-01 | 0.1153 |
55634 | KRBOX4 | P20T-E | Human | Esophagus | ESCC | 3.50e-09 | 1.52e-01 | 0.1124 |
55634 | KRBOX4 | P21T-E | Human | Esophagus | ESCC | 8.40e-04 | 8.10e-02 | 0.1617 |
55634 | KRBOX4 | P22T-E | Human | Esophagus | ESCC | 5.17e-27 | 3.93e-01 | 0.1236 |
55634 | KRBOX4 | P23T-E | Human | Esophagus | ESCC | 2.36e-16 | 2.66e-01 | 0.108 |
55634 | KRBOX4 | P24T-E | Human | Esophagus | ESCC | 1.82e-09 | 8.85e-02 | 0.1287 |
55634 | KRBOX4 | P26T-E | Human | Esophagus | ESCC | 4.24e-18 | 3.13e-01 | 0.1276 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRBOX4 | SNV | Missense_Mutation | c.58G>C | p.Glu20Gln | p.E20Q | Q5JUW0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KRBOX4 | SNV | Missense_Mutation | c.508N>C | p.Glu170Gln | p.E170Q | Q5JUW0 | protein_coding | deleterious_low_confidence(0.04) | benign(0.007) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KRBOX4 | SNV | Missense_Mutation | c.208N>C | p.Asp70His | p.D70H | Q5JUW0 | protein_coding | tolerated(0.05) | benign(0.003) | TCGA-D8-A27M-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate+5 | SD | |
KRBOX4 | insertion | Frame_Shift_Ins | novel | c.111_112insTGCACCTCACGCT | p.Leu38CysfsTer6 | p.L38Cfs*6 | Q5JUW0 | protein_coding | TCGA-A2-A0CP-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | ||
KRBOX4 | SNV | Missense_Mutation | c.504N>C | p.Lys168Asn | p.K168N | Q5JUW0 | protein_coding | deleterious_low_confidence(0.02) | benign(0.124) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
KRBOX4 | SNV | Missense_Mutation | novel | c.107N>C | p.Val36Ala | p.V36A | Q5JUW0 | protein_coding | deleterious(0) | possibly_damaging(0.551) | TCGA-VS-A9UJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
KRBOX4 | SNV | Missense_Mutation | c.34N>T | p.Asp12Tyr | p.D12Y | Q5JUW0 | protein_coding | deleterious(0) | possibly_damaging(0.77) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
KRBOX4 | SNV | Missense_Mutation | rs760154730 | c.358G>A | p.Gly120Ser | p.G120S | Q5JUW0 | protein_coding | tolerated(0.08) | probably_damaging(0.997) | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRBOX4 | SNV | Missense_Mutation | c.364N>A | p.Glu122Lys | p.E122K | Q5JUW0 | protein_coding | deleterious(0.02) | benign(0.303) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
KRBOX4 | SNV | Missense_Mutation | novel | c.218N>T | p.Thr73Ile | p.T73I | Q5JUW0 | protein_coding | tolerated(0.24) | benign(0.001) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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