Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KPNA6

Gene summary for KPNA6

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KPNA6

Gene ID

23633

Gene namekaryopherin subunit alpha 6
Gene AliasIPOA7
Cytomap1p35.2
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

O60684


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
23633KPNA6HTA11_3410_2000001011HumanColorectumAD3.92e-041.33e-010.0155
23633KPNA6HTA11_1938_2000001011HumanColorectumAD8.72e-044.98e-01-0.0811
23633KPNA6HTA11_78_2000001011HumanColorectumAD2.92e-033.98e-01-0.1088
23633KPNA6HTA11_347_2000001011HumanColorectumAD5.76e-145.12e-01-0.1954
23633KPNA6HTA11_2112_2000001011HumanColorectumSER2.34e-047.04e-01-0.2196
23633KPNA6HTA11_1391_2000001011HumanColorectumAD2.71e-126.73e-01-0.059
23633KPNA6HTA11_546_2000001011HumanColorectumAD1.15e-034.86e-01-0.0842
23633KPNA6HTA11_866_3004761011HumanColorectumAD4.21e-032.57e-010.096
23633KPNA6HTA11_4255_2000001011HumanColorectumSER3.13e-034.89e-010.0446
23633KPNA6HTA11_6818_2000001021HumanColorectumAD2.16e-043.67e-010.0588
23633KPNA6HTA11_99999965104_69814HumanColorectumMSS6.54e-085.33e-010.281
23633KPNA6HTA11_99999971662_82457HumanColorectumMSS1.04e-086.84e-010.3859
23633KPNA6A002-C-010HumanColorectumFAP1.72e-02-1.04e-010.242
23633KPNA6A015-C-203HumanColorectumFAP6.62e-13-2.43e-01-0.1294
23633KPNA6A002-C-201HumanColorectumFAP1.51e-06-2.75e-010.0324
23633KPNA6A001-C-108HumanColorectumFAP6.25e-07-1.15e-01-0.0272
23633KPNA6A002-C-205HumanColorectumFAP7.30e-07-1.69e-01-0.1236
23633KPNA6A015-C-006HumanColorectumFAP4.21e-05-1.42e-01-0.0994
23633KPNA6A015-C-106HumanColorectumFAP1.55e-08-2.35e-01-0.0511
23633KPNA6A002-C-114HumanColorectumFAP4.86e-05-1.98e-01-0.1561
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0016032ColorectumADviral process168/3918415/187234.67e-203.66e-17168
GO:0019058ColorectumADviral life cycle119/3918317/187236.18e-128.23e-10119
GO:0072594ColorectumADestablishment of protein localization to organelle148/3918422/187237.95e-121.04e-09148
GO:0006913ColorectumADnucleocytoplasmic transport102/3918301/187231.00e-074.85e-06102
GO:0051169ColorectumADnuclear transport102/3918301/187231.00e-074.85e-06102
GO:0048524ColorectumADpositive regulation of viral process31/391865/187231.33e-064.23e-0531
GO:0019079ColorectumADviral genome replication51/3918131/187231.83e-065.51e-0551
GO:0034504ColorectumADprotein localization to nucleus94/3918290/187232.83e-068.09e-0594
GO:0050792ColorectumADregulation of viral process59/3918164/187235.95e-061.52e-0459
GO:0017038ColorectumADprotein import67/3918206/187236.34e-051.05e-0367
GO:1903900ColorectumADregulation of viral life cycle51/3918148/187239.01e-051.38e-0351
GO:0051170ColorectumADimport into nucleus53/3918159/187231.76e-042.38e-0353
GO:0006606ColorectumADprotein import into nucleus51/3918155/187233.29e-043.86e-0351
GO:1903902ColorectumADpositive regulation of viral life cycle14/391829/187239.40e-048.92e-0314
GO:00160321ColorectumSERviral process118/2897415/187238.36e-121.65e-09118
GO:00725941ColorectumSERestablishment of protein localization to organelle111/2897422/187234.98e-094.49e-07111
GO:00190581ColorectumSERviral life cycle87/2897317/187232.82e-081.94e-0687
GO:00069131ColorectumSERnucleocytoplasmic transport77/2897301/187233.39e-061.32e-0477
GO:00511691ColorectumSERnuclear transport77/2897301/187233.39e-061.32e-0477
GO:00345041ColorectumSERprotein localization to nucleus74/2897290/187235.74e-062.05e-0474
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05207ColorectumCRCChemical carcinogenesis - receptor activation42/1091212/84652.62e-031.75e-021.19e-0242
hsa052071ColorectumCRCChemical carcinogenesis - receptor activation42/1091212/84652.62e-031.75e-021.19e-0242
hsa0301321EsophagusESCCNucleocytoplasmic transport89/4205108/84651.20e-122.37e-111.21e-1189
hsa0516425EsophagusESCCInfluenza A122/4205171/84655.01e-094.79e-082.45e-08122
hsa0301331EsophagusESCCNucleocytoplasmic transport89/4205108/84651.20e-122.37e-111.21e-1189
hsa0516435EsophagusESCCInfluenza A122/4205171/84655.01e-094.79e-082.45e-08122
hsa0516410LiverCirrhoticInfluenza A66/2530171/84658.56e-032.91e-021.79e-0266
hsa0516411LiverCirrhoticInfluenza A66/2530171/84658.56e-032.91e-021.79e-0266
hsa03013LiverHCCNucleocytoplasmic transport81/4020108/84654.28e-096.83e-083.80e-0881
hsa0516421LiverHCCInfluenza A101/4020171/84651.41e-035.07e-032.82e-03101
hsa030131LiverHCCNucleocytoplasmic transport81/4020108/84654.28e-096.83e-083.80e-0881
hsa0516431LiverHCCInfluenza A101/4020171/84651.41e-035.07e-032.82e-03101
hsa0516412LungIACInfluenza A35/1053171/84651.82e-031.00e-026.66e-0335
hsa0516413LungIACInfluenza A35/1053171/84651.82e-031.00e-026.66e-0335
hsa030136Oral cavityOSCCNucleocytoplasmic transport82/3704108/84657.93e-121.33e-106.77e-1182
hsa0516418Oral cavityOSCCInfluenza A116/3704171/84651.23e-101.78e-099.08e-10116
hsa0301311Oral cavityOSCCNucleocytoplasmic transport82/3704108/84657.93e-121.33e-106.77e-1182
hsa0516419Oral cavityOSCCInfluenza A116/3704171/84651.23e-101.78e-099.08e-10116
hsa0516424Oral cavityLPInfluenza A80/2418171/84652.56e-073.41e-062.20e-0680
hsa030132Oral cavityLPNucleocytoplasmic transport53/2418108/84654.68e-064.10e-052.64e-0553
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KPNA6SNVMissense_Mutationc.1168N>Ap.Ala390Thrp.A390TO60684protein_codingdeleterious(0.01)possibly_damaging(0.481)TCGA-A2-A0CT-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycytoxanSD
KPNA6SNVMissense_Mutationc.128G>Ap.Arg43Glnp.R43QO60684protein_codingdeleterious(0)probably_damaging(0.941)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KPNA6SNVMissense_Mutationnovelc.1153G>Ap.Glu385Lysp.E385KO60684protein_codingtolerated(0.31)benign(0.033)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KPNA6SNVMissense_Mutationnovelc.981N>Gp.Ile327Metp.I327MO60684protein_codingtolerated(0.38)benign(0.01)TCGA-S3-A6ZF-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapytaxotereCR
KPNA6insertionFrame_Shift_Insnovelc.849_850insTGGAGATp.Asn284TrpfsTer3p.N284Wfs*3O60684protein_codingTCGA-BH-A0HY-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytaxotereCR
KPNA6insertionIn_Frame_Insnovelc.851_852insAGATACAACTTCCATTTCTCCCATp.Asn284delinsLysAspThrThrSerIleSerProIlep.N284delinsKDTTSISPIO60684protein_codingTCGA-BH-A0HY-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytaxotereCR
KPNA6deletionFrame_Shift_Delnovelc.1480delGp.Ala494ProfsTer11p.A494Pfs*11O60684protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
KPNA6deletionFrame_Shift_Delnovelc.1436delNp.Ile479MetfsTer26p.I479Mfs*26O60684protein_codingTCGA-S3-AA17-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyanastrozoleSD
KPNA6SNVMissense_Mutationc.86N>Ap.Arg29Glnp.R29QO60684protein_codingdeleterious(0)probably_damaging(0.921)TCGA-A6-3810-01Colorectumcolon adenocarcinomaMale<65I/IIUnknownUnknownSD
KPNA6SNVMissense_Mutationrs201663407c.1519G>Ap.Asp507Asnp.D507NO60684protein_codingdeleterious(0.02)benign(0.009)TCGA-A6-5661-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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