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Gene: KPNA5 |
Gene summary for KPNA5 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KPNA5 | Gene ID | 3841 |
| Gene name | karyopherin subunit alpha 5 | |
| Gene Alias | IPOA6 | |
| Cytomap | 6q22.1 | |
| Gene Type | protein-coding | GO ID | GO:0006606 | UniProtAcc | O15131 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 3841 | KPNA5 | male-WTA | Human | Thyroid | PTC | 1.52e-10 | 2.79e-02 | 0.1037 |
| 3841 | KPNA5 | PTC01 | Human | Thyroid | PTC | 3.30e-06 | 4.80e-02 | 0.1899 |
| 3841 | KPNA5 | PTC04 | Human | Thyroid | PTC | 5.30e-12 | 1.37e-01 | 0.1927 |
| 3841 | KPNA5 | PTC05 | Human | Thyroid | PTC | 4.69e-02 | 3.13e-01 | 0.2065 |
| 3841 | KPNA5 | PTC06 | Human | Thyroid | PTC | 2.59e-20 | 3.15e-01 | 0.2057 |
| 3841 | KPNA5 | PTC07 | Human | Thyroid | PTC | 8.91e-24 | 2.70e-01 | 0.2044 |
| 3841 | KPNA5 | ATC09 | Human | Thyroid | ATC | 3.58e-03 | 5.12e-02 | 0.2871 |
| 3841 | KPNA5 | ATC12 | Human | Thyroid | ATC | 2.99e-05 | 6.40e-02 | 0.34 |
| 3841 | KPNA5 | ATC13 | Human | Thyroid | ATC | 3.33e-27 | 4.61e-01 | 0.34 |
| 3841 | KPNA5 | ATC1 | Human | Thyroid | ATC | 4.03e-02 | 5.05e-02 | 0.2878 |
| 3841 | KPNA5 | ATC2 | Human | Thyroid | ATC | 1.26e-04 | 1.94e-01 | 0.34 |
| 3841 | KPNA5 | ATC4 | Human | Thyroid | ATC | 4.13e-05 | 1.12e-01 | 0.34 |
| 3841 | KPNA5 | ATC5 | Human | Thyroid | ATC | 6.18e-33 | 5.04e-01 | 0.34 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:0072594112 | Thyroid | PTC | establishment of protein localization to organelle | 244/5968 | 422/18723 | 1.18e-28 | 4.97e-26 | 244 |
| GO:0006913112 | Thyroid | PTC | nucleocytoplasmic transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
| GO:0051169112 | Thyroid | PTC | nuclear transport | 181/5968 | 301/18723 | 2.93e-24 | 7.69e-22 | 181 |
| GO:0034504111 | Thyroid | PTC | protein localization to nucleus | 170/5968 | 290/18723 | 3.34e-21 | 6.38e-19 | 170 |
| GO:0017038111 | Thyroid | PTC | protein import | 109/5968 | 206/18723 | 2.74e-10 | 8.96e-09 | 109 |
| GO:005117017 | Thyroid | PTC | import into nucleus | 85/5968 | 159/18723 | 1.30e-08 | 3.08e-07 | 85 |
| GO:000660616 | Thyroid | PTC | protein import into nucleus | 82/5968 | 155/18723 | 4.32e-08 | 9.27e-07 | 82 |
| GO:007259429 | Thyroid | ATC | establishment of protein localization to organelle | 247/6293 | 422/18723 | 2.88e-26 | 1.40e-23 | 247 |
| GO:003450423 | Thyroid | ATC | protein localization to nucleus | 175/6293 | 290/18723 | 6.23e-21 | 1.23e-18 | 175 |
| GO:000691326 | Thyroid | ATC | nucleocytoplasmic transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
| GO:005116926 | Thyroid | ATC | nuclear transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
| GO:001703822 | Thyroid | ATC | protein import | 110/6293 | 206/18723 | 3.49e-09 | 8.09e-08 | 110 |
| GO:005117018 | Thyroid | ATC | import into nucleus | 86/6293 | 159/18723 | 8.02e-08 | 1.40e-06 | 86 |
| GO:000660617 | Thyroid | ATC | protein import into nucleus | 83/6293 | 155/18723 | 2.38e-07 | 3.70e-06 | 83 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KPNA5 | SNV | Missense_Mutation | c.292G>A | p.Asp98Asn | p.D98N | O15131 | protein_coding | tolerated(0.47) | benign(0.005) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
| KPNA5 | SNV | Missense_Mutation | c.1235N>A | p.Gly412Asp | p.G412D | O15131 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KPNA5 | SNV | Missense_Mutation | c.1322T>C | p.Val441Ala | p.V441A | O15131 | protein_coding | deleterious(0.01) | probably_damaging(0.997) | TCGA-BH-A0E2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
| KPNA5 | SNV | Missense_Mutation | c.1016N>G | p.Ser339Cys | p.S339C | O15131 | protein_coding | deleterious(0.01) | possibly_damaging(0.765) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KPNA5 | deletion | Frame_Shift_Del | novel | c.111_112delNN | p.Gln37HisfsTer2 | p.Q37Hfs*2 | O15131 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| KPNA5 | insertion | Frame_Shift_Ins | novel | c.112_113insTATT | p.Arg39PhefsTer2 | p.R39Ffs*2 | O15131 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| KPNA5 | insertion | Nonsense_Mutation | novel | c.991_992insTGGTCACTAATT | p.Gln331delinsLeuValThrAsnTer | p.Q331delinsLVTN* | O15131 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| KPNA5 | insertion | Frame_Shift_Ins | novel | c.1349_1350insGACTATAAAATACAGACACAAACTGG | p.Asn450LysfsTer24 | p.N450Kfs*24 | O15131 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| KPNA5 | SNV | Missense_Mutation | novel | c.740C>A | p.Pro247His | p.P247H | O15131 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| KPNA5 | SNV | Missense_Mutation | novel | c.1597C>T | p.Pro533Ser | p.P533S | O15131 | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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