Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

Home

Download

Statistics

Help

Contact
Center for Computational Systems Medicine
leaf

Gene summary

leaf

Malignant transformation analysis

leaf

Malignant transformation related pathway analysis

leaf

Cell-cell communication analysis

leaf

Single-cell gene regulatory network inference analysis

leaf

Somatic mutation of malignant transformation related genes

leaf

Related drugs of malignant transformation related genes

Gene: KMO

Gene summary for KMO

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KMO

Gene ID

8564

Gene namekynurenine 3-monooxygenase
Gene AliasdJ317G22.1
Cytomap1q43
Gene Typeprotein-coding
GO ID

GO:0001505

UniProtAcc

A8K693


Top

Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8564KMOEEC-subject2HumanEndometriumEEC3.87e-05-9.87e-02-0.2607
8564KMOEEC-subject3HumanEndometriumEEC1.42e-02-7.74e-02-0.2525
8564KMOEEC-subject5HumanEndometriumEEC2.59e-02-8.98e-02-0.249
8564KMOGSM5276934HumanEndometriumEEC1.82e-05-1.07e-01-0.0913
8564KMOGSM6177621_NYU_UCEC2_lib1_lib1HumanEndometriumEEC5.81e-03-9.36e-02-0.1934
8564KMOGSM6177622_NYU_UCEC3_lib1_lib1HumanEndometriumEEC1.82e-05-1.07e-01-0.1917
8564KMOGSM6177622_NYU_UCEC3_lib2_lib2HumanEndometriumEEC3.49e-02-1.07e-01-0.1916
8564KMOGSM6177623_NYU_UCEC3_VisHumanEndometriumEEC2.54e-02-9.89e-02-0.1269
Page: 1 

check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

Top

Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
Page: 1 2 3 4 5 6 7 8 9 

check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:190121617EndometriumEECpositive regulation of neuron death28/216897/187233.08e-068.48e-0528
GO:004427013EndometriumEECcellular nitrogen compound catabolic process83/2168451/187231.17e-052.43e-0483
GO:004670013EndometriumEECheterocycle catabolic process82/2168445/187231.26e-052.55e-0482
GO:000756815EndometriumEECaging66/2168339/187231.46e-052.87e-0466
GO:000223714EndometriumEECresponse to molecule of bacterial origin68/2168363/187233.96e-056.64e-0468
GO:003249614EndometriumEECresponse to lipopolysaccharide65/2168343/187234.04e-056.75e-0465
GO:001943913EndometriumEECaromatic compound catabolic process83/2168467/187234.32e-057.10e-0483
GO:190136113EndometriumEECorganic cyclic compound catabolic process86/2168495/187237.31e-051.07e-0386
GO:000911716EndometriumEECnucleotide metabolic process80/2168489/187238.65e-047.95e-0380
GO:007122213EndometriumEECcellular response to lipopolysaccharide40/2168209/187239.31e-048.37e-0340
GO:007121613EndometriumEECcellular response to biotic stimulus45/2168246/187231.24e-031.03e-0245
GO:000675315EndometriumEECnucleoside phosphate metabolic process80/2168497/187231.39e-031.14e-0280
GO:007099717EndometriumEECneuron death60/2168361/187232.49e-031.83e-0260
GO:190121417EndometriumEECregulation of neuron death54/2168319/187232.67e-031.93e-0254
GO:007121913EndometriumEECcellular response to molecule of bacterial origin40/2168221/187232.73e-031.97e-0240
GO:000697012EndometriumEECresponse to osmotic stress19/216884/187232.98e-032.10e-0219
GO:00091656EndometriumEECnucleotide biosynthetic process43/2168254/187236.79e-033.95e-0243
GO:007055511EndometriumEECresponse to interleukin-127/2168143/187236.99e-034.01e-0227
GO:19012936EndometriumEECnucleoside phosphate biosynthetic process43/2168256/187237.79e-034.34e-0243
Page: 1 

check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
Page: 1 

Top

Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
Page: 1 

Top

Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
Page: 1 

Top

Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KMOSNVMissense_Mutationc.1359N>Cp.Leu453Phep.L453FO15229protein_codingtolerated_low_confidence(0.18)benign(0.003)TCGA-A2-A0CM-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapyadriamycinPD
KMOSNVMissense_Mutationc.763G>Cp.Asp255Hisp.D255HO15229protein_codingtolerated(0.06)possibly_damaging(0.701)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
KMOSNVMissense_Mutationnovelc.334G>Cp.Glu112Glnp.E112QO15229protein_codingtolerated(0.14)benign(0.403)TCGA-AC-A3W6-01Breastbreast invasive carcinomaFemale>=65III/IVUnknownUnknownSD
KMOSNVMissense_Mutationnovelc.947G>Ap.Gly316Glup.G316EO15229protein_codingdeleterious(0)probably_damaging(1)TCGA-AC-A5EH-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KMOSNVMissense_Mutationnovelc.308C>Ap.Ser103Tyrp.S103YO15229protein_codingdeleterious(0)benign(0.3)TCGA-AN-A046-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KMOSNVMissense_Mutationrs771245652c.1391G>Ap.Arg464Glnp.R464QO15229protein_codingtolerated_low_confidence(0.56)benign(0)TCGA-D8-A1XQ-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KMOSNVMissense_Mutationc.982N>Cp.Asp328Hisp.D328HO15229protein_codingtolerated(0.08)benign(0.377)TCGA-E2-A14P-01Breastbreast invasive carcinomaFemale>=65III/IVTargeted Molecular therapytrastuzumabSD
KMOinsertionFrame_Shift_Insnovelc.601_602insAGGATTTTp.Pro201GlnfsTer25p.P201Qfs*25O15229protein_codingTCGA-AR-A0TU-01Breastbreast invasive carcinomaFemale<65I/IIUnspecificDoxorubicinSD
KMOdeletionFrame_Shift_Delnovelc.30delAp.Val11Terp.V11*O15229protein_codingTCGA-D8-A27V-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
KMOSNVMissense_Mutationnovelc.586N>Ap.Glu196Lysp.E196KO15229protein_codingdeleterious(0)probably_damaging(1)TCGA-VS-A8EI-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
Page: 1 2 3 4 5 6 7 8 

Top

Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
8564KMODRUGGABLE GENOME, ENZYMEPyrimidine benzenesulfonamide derivative 2
8564KMODRUGGABLE GENOME, ENZYMEIsoxazoles and isoxazoline derivative 6
8564KMODRUGGABLE GENOME, ENZYMECyclopropane 1-carboxylic acid derivative 1
8564KMODRUGGABLE GENOME, ENZYMEIsoxazoles and isoxazoline derivative 2
8564KMODRUGGABLE GENOME, ENZYMEPMID27172114-Compound-49
8564KMODRUGGABLE GENOME, ENZYMECyclopropane 1-carboxylic acid derivative 8
8564KMODRUGGABLE GENOME, ENZYMECyclopropane 1-carboxylic acid derivative 2
8564KMODRUGGABLE GENOME, ENZYMEAryl pyrimidine derivative 9
8564KMODRUGGABLE GENOME, ENZYMEIsoxazoles and isoxazoline derivative 1
8564KMODRUGGABLE GENOME, ENZYMEBenzene sulfonamide derivative 2
Page: 1 2 3 4