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Gene: KLRG2 |
Gene summary for KLRG2 |
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Gene information | Species | Human | Gene symbol | KLRG2 | Gene ID | 346689 |
Gene name | killer cell lectin like receptor G2 | |
Gene Alias | CLEC15B | |
Cytomap | 7q34 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | A4D1S0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
346689 | KLRG2 | LZE24T | Human | Esophagus | ESCC | 3.01e-02 | 1.69e-01 | 0.0596 |
346689 | KLRG2 | P2T-E | Human | Esophagus | ESCC | 1.92e-07 | 1.32e-01 | 0.1177 |
346689 | KLRG2 | P4T-E | Human | Esophagus | ESCC | 8.04e-23 | 5.86e-01 | 0.1323 |
346689 | KLRG2 | P5T-E | Human | Esophagus | ESCC | 4.19e-25 | 4.86e-01 | 0.1327 |
346689 | KLRG2 | P9T-E | Human | Esophagus | ESCC | 5.26e-17 | 4.04e-01 | 0.1131 |
346689 | KLRG2 | P12T-E | Human | Esophagus | ESCC | 2.29e-22 | 5.34e-01 | 0.1122 |
346689 | KLRG2 | P15T-E | Human | Esophagus | ESCC | 1.24e-08 | 3.06e-01 | 0.1149 |
346689 | KLRG2 | P16T-E | Human | Esophagus | ESCC | 2.33e-11 | 2.93e-01 | 0.1153 |
346689 | KLRG2 | P20T-E | Human | Esophagus | ESCC | 4.00e-06 | 2.29e-01 | 0.1124 |
346689 | KLRG2 | P21T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.65e-01 | 0.1617 |
346689 | KLRG2 | P22T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.02e-01 | 0.1236 |
346689 | KLRG2 | P23T-E | Human | Esophagus | ESCC | 9.29e-07 | 2.40e-01 | 0.108 |
346689 | KLRG2 | P24T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.83e-01 | 0.1287 |
346689 | KLRG2 | P26T-E | Human | Esophagus | ESCC | 1.97e-10 | 2.13e-01 | 0.1276 |
346689 | KLRG2 | P27T-E | Human | Esophagus | ESCC | 6.62e-20 | 4.12e-01 | 0.1055 |
346689 | KLRG2 | P28T-E | Human | Esophagus | ESCC | 3.11e-50 | 9.22e-01 | 0.1149 |
346689 | KLRG2 | P30T-E | Human | Esophagus | ESCC | 1.58e-26 | 9.67e-01 | 0.137 |
346689 | KLRG2 | P31T-E | Human | Esophagus | ESCC | 9.74e-22 | 4.25e-01 | 0.1251 |
346689 | KLRG2 | P36T-E | Human | Esophagus | ESCC | 3.19e-03 | 2.18e-01 | 0.1187 |
346689 | KLRG2 | P39T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.16e-01 | 0.0894 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLRG2 | SNV | Missense_Mutation | rs752055129 | c.1058N>A | p.Arg353Gln | p.R353Q | A4D1S0 | protein_coding | deleterious(0.02) | probably_damaging(0.951) | TCGA-ZJ-AAX4-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KLRG2 | deletion | Frame_Shift_Del | c.1095delN | p.Leu366SerfsTer67 | p.L366Sfs*67 | A4D1S0 | protein_coding | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
KLRG2 | SNV | Missense_Mutation | novel | c.991C>A | p.Leu331Ile | p.L331I | A4D1S0 | protein_coding | tolerated(0.31) | possibly_damaging(0.684) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KLRG2 | SNV | Missense_Mutation | rs752055129 | c.1058G>A | p.Arg353Gln | p.R353Q | A4D1S0 | protein_coding | deleterious(0.02) | probably_damaging(0.951) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
KLRG2 | SNV | Missense_Mutation | novel | c.1005N>T | p.Gln335His | p.Q335H | A4D1S0 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-AP-A1DM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLRG2 | SNV | Missense_Mutation | novel | c.1178C>A | p.Ala393Asp | p.A393D | A4D1S0 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
KLRG2 | SNV | Missense_Mutation | novel | c.982N>A | p.Leu328Ile | p.L328I | A4D1S0 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
KLRG2 | SNV | Missense_Mutation | novel | c.740G>A | p.Arg247Gln | p.R247Q | A4D1S0 | protein_coding | tolerated(0.09) | benign(0.141) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
KLRG2 | SNV | Missense_Mutation | rs538203577 | c.1169C>T | p.Thr390Met | p.T390M | A4D1S0 | protein_coding | deleterious(0.04) | possibly_damaging(0.496) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLRG2 | SNV | Missense_Mutation | rs138023732 | c.932N>T | p.Ala311Val | p.A311V | A4D1S0 | protein_coding | tolerated(0.23) | benign(0.028) | TCGA-CC-5260-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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