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Gene: KLHL28 |
Gene summary for KLHL28 |
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Gene information | Species | Human | Gene symbol | KLHL28 | Gene ID | 54813 |
Gene name | kelch like family member 28 | |
Gene Alias | BTBD5 | |
Cytomap | 14q21.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A8K1E0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54813 | KLHL28 | LZE4T | Human | Esophagus | ESCC | 1.14e-15 | 4.99e-01 | 0.0811 |
54813 | KLHL28 | LZE5T | Human | Esophagus | ESCC | 1.59e-02 | 2.88e-01 | 0.0514 |
54813 | KLHL28 | LZE7T | Human | Esophagus | ESCC | 1.99e-02 | 1.11e-01 | 0.0667 |
54813 | KLHL28 | LZE20T | Human | Esophagus | ESCC | 4.46e-03 | 1.06e-01 | 0.0662 |
54813 | KLHL28 | LZE24T | Human | Esophagus | ESCC | 5.72e-11 | 3.85e-01 | 0.0596 |
54813 | KLHL28 | P2T-E | Human | Esophagus | ESCC | 1.25e-17 | 2.27e-01 | 0.1177 |
54813 | KLHL28 | P4T-E | Human | Esophagus | ESCC | 1.10e-12 | 3.90e-01 | 0.1323 |
54813 | KLHL28 | P5T-E | Human | Esophagus | ESCC | 6.34e-14 | 2.37e-01 | 0.1327 |
54813 | KLHL28 | P8T-E | Human | Esophagus | ESCC | 1.04e-13 | 2.40e-01 | 0.0889 |
54813 | KLHL28 | P9T-E | Human | Esophagus | ESCC | 2.50e-10 | 1.28e-01 | 0.1131 |
54813 | KLHL28 | P10T-E | Human | Esophagus | ESCC | 2.30e-24 | 4.90e-01 | 0.116 |
54813 | KLHL28 | P11T-E | Human | Esophagus | ESCC | 3.65e-10 | 3.93e-01 | 0.1426 |
54813 | KLHL28 | P12T-E | Human | Esophagus | ESCC | 3.89e-32 | 6.12e-01 | 0.1122 |
54813 | KLHL28 | P15T-E | Human | Esophagus | ESCC | 2.25e-34 | 6.93e-01 | 0.1149 |
54813 | KLHL28 | P16T-E | Human | Esophagus | ESCC | 1.72e-20 | 3.84e-01 | 0.1153 |
54813 | KLHL28 | P17T-E | Human | Esophagus | ESCC | 1.55e-03 | 2.37e-01 | 0.1278 |
54813 | KLHL28 | P20T-E | Human | Esophagus | ESCC | 5.14e-10 | 2.77e-01 | 0.1124 |
54813 | KLHL28 | P21T-E | Human | Esophagus | ESCC | 1.58e-09 | 2.13e-01 | 0.1617 |
54813 | KLHL28 | P22T-E | Human | Esophagus | ESCC | 2.93e-12 | 1.50e-01 | 0.1236 |
54813 | KLHL28 | P23T-E | Human | Esophagus | ESCC | 5.05e-18 | 3.84e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL28 | SNV | Missense_Mutation | novel | c.358N>A | p.Glu120Lys | p.E120K | protein_coding | deleterious(0) | benign(0.228) | TCGA-A2-A0YD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
KLHL28 | SNV | Missense_Mutation | rs573907160 | c.776N>A | p.Arg259His | p.R259H | protein_coding | deleterious(0.03) | possibly_damaging(0.893) | TCGA-AO-A03O-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | doxorubicin | SD | |
KLHL28 | SNV | Missense_Mutation | novel | c.1357N>A | p.Gly453Ser | p.G453S | protein_coding | deleterious(0.01) | probably_damaging(1) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR | |
KLHL28 | SNV | Missense_Mutation | novel | c.1719N>A | p.Met573Ile | p.M573I | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-OL-A6VO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR | |
KLHL28 | insertion | Nonsense_Mutation | novel | c.1459_1460insAGAATCGCTAGAACCGAGATC | p.Gly487delinsGluAsnArgTerAsnArgAspArg | p.G487delinsENR*NRDR | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
KLHL28 | insertion | In_Frame_Ins | novel | c.1457_1458insACTCGGGAGGCTGAGGCA | p.Phe486delinsLeuLeuGlyArgLeuArgHis | p.F486delinsLLGRLRH | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
KLHL28 | SNV | Missense_Mutation | novel | c.1340N>C | p.Gly447Ala | p.G447A | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
KLHL28 | SNV | Missense_Mutation | rs373899846 | c.208N>A | p.Val70Ile | p.V70I | protein_coding | tolerated(0.28) | benign(0) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL28 | SNV | Missense_Mutation | c.493N>A | p.Asp165Asn | p.D165N | protein_coding | deleterious(0.04) | benign(0.302) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
KLHL28 | SNV | Missense_Mutation | c.1310N>T | p.Arg437Ile | p.R437I | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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