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Gene: KLF8 |
Gene summary for KLF8 |
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Gene information | Species | Human | Gene symbol | KLF8 | Gene ID | 11279 |
Gene name | Kruppel like factor 8 | |
Gene Alias | BKLF3 | |
Cytomap | Xp11.21 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O95600 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11279 | KLF8 | HCC1 | Human | Liver | HCC | 4.51e-09 | 1.05e+00 | 0.5336 |
11279 | KLF8 | HCC2 | Human | Liver | HCC | 1.55e-17 | 1.02e+00 | 0.5341 |
11279 | KLF8 | HCC5 | Human | Liver | HCC | 1.00e-10 | 9.99e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLF8 | SNV | Missense_Mutation | novel | c.1042N>T | p.His348Tyr | p.H348Y | O95600 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
KLF8 | SNV | Missense_Mutation | c.1039G>C | p.Asp347His | p.D347H | O95600 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-2677-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Ancillary | leucovorin | SD | |
KLF8 | SNV | Missense_Mutation | c.1064G>A | p.Arg355His | p.R355H | O95600 | protein_coding | deleterious(0.03) | probably_damaging(0.996) | TCGA-A6-6649-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | SD | |
KLF8 | SNV | Missense_Mutation | c.1054N>T | p.His352Tyr | p.H352Y | O95600 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KLF8 | SNV | Missense_Mutation | rs745530968 | c.1034G>A | p.Arg345His | p.R345H | O95600 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KLF8 | SNV | Missense_Mutation | c.1061G>A | p.Arg354His | p.R354H | O95600 | protein_coding | deleterious(0) | probably_damaging(0.988) | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KLF8 | SNV | Missense_Mutation | c.937N>A | p.Trp313Arg | p.W313R | O95600 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KLF8 | SNV | Missense_Mutation | c.310N>A | p.Leu104Ile | p.L104I | O95600 | protein_coding | tolerated(0.06) | possibly_damaging(0.775) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KLF8 | SNV | Missense_Mutation | c.976N>T | p.Arg326Cys | p.R326C | O95600 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-CA-6719-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
KLF8 | SNV | Missense_Mutation | c.950N>A | p.Arg317His | p.R317H | O95600 | protein_coding | deleterious(0.03) | probably_damaging(0.913) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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