Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KLF15

Gene summary for KLF15

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KLF15

Gene ID

28999

Gene nameKruppel like factor 15
Gene AliasKKLF
Cytomap3q21.3
Gene Typeprotein-coding
GO ID

GO:0001655

UniProtAcc

Q9UIH9


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
28999KLF15NAFLD1HumanLiverNAFLD2.36e-023.75e-01-0.04
28999KLF15HCC1_MengHumanLiverHCC4.58e-06-1.31e-020.0246
28999KLF15HCC1HumanLiverHCC1.09e-021.91e+000.5336
28999KLF15HCC2HumanLiverHCC1.04e-061.95e+000.5341
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:19016536LiverNAFLDcellular response to peptide71/1882359/187231.82e-082.09e-0671
GO:00434346LiverNAFLDresponse to peptide hormone76/1882414/187231.51e-071.09e-0576
GO:00328685LiverNAFLDresponse to insulin53/1882264/187236.99e-073.95e-0553
GO:00160555LiverNAFLDWnt signaling pathway74/1882444/187238.98e-062.96e-0474
GO:0018205LiverNAFLDpeptidyl-lysine modification65/1882376/187239.42e-063.02e-0465
GO:01987385LiverNAFLDcell-cell signaling by wnt74/1882446/187231.05e-053.33e-0474
GO:00301115LiverNAFLDregulation of Wnt signaling pathway57/1882328/187232.79e-057.46e-0457
GO:00463241LiverNAFLDregulation of glucose import16/188259/187231.68e-043.06e-0316
GO:0043543LiverNAFLDprotein acylation43/1882243/187231.70e-043.07e-0343
GO:00425936LiverNAFLDglucose homeostasis45/1882258/187231.71e-043.08e-0345
GO:00335006LiverNAFLDcarbohydrate homeostasis45/1882259/187231.87e-043.29e-0345
GO:0006473LiverNAFLDprotein acetylation37/1882201/187232.10e-043.61e-0337
GO:0046326LiverNAFLDpositive regulation of glucose import12/188239/187233.02e-044.75e-0312
GO:0018394LiverNAFLDpeptidyl-lysine acetylation32/1882169/187233.24e-045.00e-0332
GO:00108281LiverNAFLDpositive regulation of glucose transmembrane transport13/188246/187234.35e-046.42e-0313
GO:00108271LiverNAFLDregulation of glucose transmembrane transport18/188277/187235.06e-047.15e-0318
GO:00033001LiverNAFLDcardiac muscle hypertrophy20/188299/187231.80e-031.85e-0220
GO:00463231LiverNAFLDglucose import16/188274/187232.43e-032.27e-0216
GO:00613183LiverNAFLDrenal filtration cell differentiation7/188220/187232.44e-032.27e-027
GO:00721123LiverNAFLDglomerular visceral epithelial cell differentiation7/188220/187232.44e-032.27e-027
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
KLF15AT1LungAISZBTB16,PEBP4,NTF4, etc.7.82e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF15AT2LLungMIACZBTB16,PEBP4,NTF4, etc.6.56e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF15LUMProstateBPHCYB5D2,DTX3L,PARP14, etc.4.95e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF15MSCProstateADJMAL,SEMA3B,GPR155, etc.4.11e-02The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF15MSCProstateHealthyMAL,SEMA3B,GPR155, etc.2.38e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KLF15SNVMissense_Mutationc.1106N>Tp.Ser369Leup.S369LQ9UIH9protein_codingdeleterious(0.02)probably_damaging(0.989)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
KLF15SNVMissense_Mutationc.521N>Tp.Ser174Leup.S174LQ9UIH9protein_codingtolerated(0.14)benign(0.081)TCGA-AC-A23H-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownPD
KLF15SNVMissense_Mutationnovelc.790C>Tp.Pro264Serp.P264SQ9UIH9protein_codingdeleterious(0.03)probably_damaging(0.997)TCGA-AO-A0J3-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapycyclophosphamideSD
KLF15SNVMissense_Mutationrs775981060c.397N>Ap.Val133Ilep.V133IQ9UIH9protein_codingtolerated(0.28)benign(0.019)TCGA-AO-A128-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapydoxorubicinSD
KLF15SNVMissense_Mutationrs867343522c.904N>Ap.Gly302Serp.G302SQ9UIH9protein_codingtolerated(0.26)benign(0.051)TCGA-AR-A2LL-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapytamoxiphenSD
KLF15SNVMissense_Mutationc.832N>Cp.Phe278Leup.F278LQ9UIH9protein_codingdeleterious(0.02)possibly_damaging(0.883)TCGA-BH-A18G-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KLF15SNVMissense_Mutationc.1219N>Tp.Arg407Trpp.R407WQ9UIH9protein_codingdeleterious(0)probably_damaging(0.999)TCGA-E2-A15C-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapyarimidexSD
KLF15SNVMissense_Mutationnovelc.56N>Cp.Val19Alap.V19AQ9UIH9protein_codingtolerated_low_confidence(0.27)benign(0.011)TCGA-E2-A56Z-01Breastbreast invasive carcinomaFemale>=65I/IIHormone TherapyarimidexSD
KLF15SNVMissense_Mutationc.809N>Tp.Ser270Phep.S270FQ9UIH9protein_codingdeleterious(0.02)possibly_damaging(0.804)TCGA-EW-A1PD-01Breastbreast invasive carcinomaMale<65I/IIChemotherapydocetaxelSD
KLF15SNVMissense_Mutationc.436G>Ap.Glu146Lysp.E146KQ9UIH9protein_codingdeleterious(0)probably_damaging(0.978)TCGA-EK-A3GM-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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