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Gene: KISS1 |
Gene summary for KISS1 |
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Gene information | Species | Human | Gene symbol | KISS1 | Gene ID | 3814 |
Gene name | KiSS-1 metastasis suppressor | |
Gene Alias | HH13 | |
Cytomap | 1q32.1 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q15726 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3814 | KISS1 | RNA-P3T-P3T-1 | Human | Lung | IAC | 1.03e-02 | 5.69e-01 | 0.1829 |
3814 | KISS1 | RNA-P3T-P3T-2 | Human | Lung | IAC | 1.96e-03 | 5.37e-01 | 0.1835 |
3814 | KISS1 | RNA-P3T-P3T-4 | Human | Lung | IAC | 4.32e-04 | 5.77e-01 | 0.1859 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485116 | Lung | IAC | rhythmic process | 65/2061 | 298/18723 | 4.57e-08 | 5.02e-06 | 65 |
GO:00434103 | Lung | IAC | positive regulation of MAPK cascade | 78/2061 | 480/18723 | 2.72e-04 | 4.50e-03 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KISS1 | SNV | Missense_Mutation | c.64N>A | p.Leu22Ile | p.L22I | Q15726 | protein_coding | tolerated(0.47) | benign(0.294) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
KISS1 | SNV | Missense_Mutation | novel | c.69N>C | p.Glu23Asp | p.E23D | Q15726 | protein_coding | tolerated(0.23) | benign(0.011) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KISS1 | insertion | Frame_Shift_Ins | rs748815895 | c.225_226insC | p.Glu76ArgfsTer91 | p.E76Rfs*91 | Q15726 | protein_coding | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KISS1 | SNV | Missense_Mutation | novel | c.320A>C | p.Lys107Thr | p.K107T | Q15726 | protein_coding | deleterious(0) | probably_damaging(0.974) | TCGA-5C-AAPD-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KISS1 | SNV | Missense_Mutation | c.345C>A | p.Asn115Lys | p.N115K | Q15726 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-60-2719-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KISS1 | SNV | Missense_Mutation | novel | c.139G>T | p.Gly47Trp | p.G47W | Q15726 | protein_coding | tolerated(1) | benign(0) | TCGA-G9-6377-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
KISS1 | SNV | Missense_Mutation | novel | c.73G>A | p.Val25Met | p.V25M | Q15726 | protein_coding | tolerated(0.37) | benign(0.124) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3814 | KISS1 | DRUGGABLE GENOME | TAK-448 | TAK-448 |
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