![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KIR3DX1 |
Gene summary for KIR3DX1 |
![]() |
Gene information | Species | Human | Gene symbol | KIR3DX1 | Gene ID | 90011 |
Gene name | killer cell immunoglobulin like receptor, three Ig domains X1 (pseudogene) | |
Gene Alias | KIR3DL0 | |
Cytomap | 19q13.42 | |
Gene Type | pseudo | GO ID | GO:0005575 | UniProtAcc | NA |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90011 | KIR3DX1 | HCC1 | Human | Liver | HCC | 3.76e-13 | 1.47e+00 | 0.5336 |
90011 | KIR3DX1 | HCC2 | Human | Liver | HCC | 1.32e-18 | 1.63e+00 | 0.5341 |
90011 | KIR3DX1 | HCC5 | Human | Liver | HCC | 2.48e-19 | 1.63e+00 | 0.4932 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIR3DX1 | SNV | Missense_Mutation | c.727T>C | p.Phe243Leu | p.F243L | Q9H7L2 | nonsense_mediated_decay | tolerated(0.69) | benign(0.403) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
KIR3DX1 | insertion | Nonsense_Mutation | novel | c.274_275insCCGTGTGTTTGCTTGCAGGGTG | p.Tyr92SerfsTer8 | p.Y92Sfs*8 | Q9H7L2 | nonsense_mediated_decay | TCGA-B6-A0IK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
KIR3DX1 | SNV | Missense_Mutation | c.842N>A | p.Ser281Tyr | p.S281Y | Q9H7L2 | nonsense_mediated_decay | tolerated(0.09) | benign(0.137) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KIR3DX1 | SNV | Missense_Mutation | c.572G>T | p.Gly191Val | p.G191V | Q9H7L2 | nonsense_mediated_decay | deleterious(0) | probably_damaging(1) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIR3DX1 | SNV | Missense_Mutation | c.551N>A | p.Pro184His | p.P184H | Q9H7L2 | nonsense_mediated_decay | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIR3DX1 | SNV | Missense_Mutation | rs757014625 | c.526N>A | p.Val176Ile | p.V176I | Q9H7L2 | nonsense_mediated_decay | tolerated(0.3) | possibly_damaging(0.755) | TCGA-AD-6899-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
KIR3DX1 | SNV | Missense_Mutation | rs752917135 | c.265N>A | p.Ala89Thr | p.A89T | Q9H7L2 | nonsense_mediated_decay | tolerated(0.05) | probably_damaging(1) | TCGA-CM-5349-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIR3DX1 | SNV | Missense_Mutation | rs776938727 | c.68N>T | p.Ala23Val | p.A23V | Q9H7L2 | nonsense_mediated_decay | tolerated(1) | benign(0) | TCGA-CM-6162-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
KIR3DX1 | SNV | Missense_Mutation | novel | c.626N>A | p.Pro209His | p.P209H | Q9H7L2 | nonsense_mediated_decay | deleterious(0) | probably_damaging(0.999) | TCGA-AG-A032-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Targeted Molecular therapy | bevacizumab | PD |
KIR3DX1 | SNV | Missense_Mutation | novel | c.967C>A | p.Leu323Ile | p.L323I | Q9H7L2 | nonsense_mediated_decay | tolerated_low_confidence(0.08) | benign(0.088) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |