Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KIF5B

Gene summary for KIF5B

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KIF5B

Gene ID

3799

Gene namekinesin family member 5B
Gene AliasHEL-S-61
Cytomap10p11.22
Gene Typeprotein-coding
GO ID

GO:0000902

UniProtAcc

P33176


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
3799KIF5BHTA11_3410_2000001011HumanColorectumAD1.89e-06-4.09e-010.0155
3799KIF5BHTA11_78_2000001011HumanColorectumAD1.16e-024.72e-01-0.1088
3799KIF5BHTA11_99999970781_79442HumanColorectumMSS1.82e-118.28e-010.294
3799KIF5BHTA11_99999965104_69814HumanColorectumMSS1.51e-055.90e-010.281
3799KIF5BHTA11_99999971662_82457HumanColorectumMSS1.16e-171.24e+000.3859
3799KIF5BA001-C-207HumanColorectumFAP1.46e-032.02e-010.1278
3799KIF5BA015-C-203HumanColorectumFAP7.42e-28-2.57e-01-0.1294
3799KIF5BA015-C-204HumanColorectumFAP1.98e-04-7.31e-02-0.0228
3799KIF5BA014-C-040HumanColorectumFAP4.39e-03-1.38e-01-0.1184
3799KIF5BA002-C-201HumanColorectumFAP1.67e-09-9.01e-020.0324
3799KIF5BA002-C-203HumanColorectumFAP1.21e-059.56e-020.2786
3799KIF5BA001-C-119HumanColorectumFAP8.26e-05-1.22e-01-0.1557
3799KIF5BA001-C-108HumanColorectumFAP7.72e-231.93e-01-0.0272
3799KIF5BA002-C-205HumanColorectumFAP9.29e-238.41e-03-0.1236
3799KIF5BA001-C-104HumanColorectumFAP5.82e-061.96e-010.0184
3799KIF5BA015-C-005HumanColorectumFAP2.01e-02-7.44e-02-0.0336
3799KIF5BA015-C-006HumanColorectumFAP4.40e-14-4.55e-03-0.0994
3799KIF5BA015-C-106HumanColorectumFAP7.80e-10-2.46e-02-0.0511
3799KIF5BA002-C-114HumanColorectumFAP2.98e-18-1.29e-01-0.1561
3799KIF5BA015-C-104HumanColorectumFAP4.89e-28-1.23e-01-0.1899
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:0072659ColorectumADprotein localization to plasma membrane122/3918284/187232.86e-171.49e-14122
GO:1990778ColorectumADprotein localization to cell periphery129/3918333/187235.51e-141.15e-11129
GO:1903829ColorectumADpositive regulation of cellular protein localization110/3918276/187234.58e-138.44e-11110
GO:0071826ColorectumADribonucleoprotein complex subunit organization94/3918227/187231.70e-122.87e-1094
GO:1905475ColorectumADregulation of protein localization to membrane73/3918175/187233.37e-102.93e-0873
GO:0022411ColorectumADcellular component disassembly147/3918443/187238.53e-106.76e-08147
GO:1904951ColorectumADpositive regulation of establishment of protein localization112/3918319/187232.55e-091.80e-07112
GO:0051656ColorectumADestablishment of organelle localization131/3918390/187233.00e-092.06e-07131
GO:0016482ColorectumADcytosolic transport68/3918168/187236.00e-093.72e-0768
GO:1903076ColorectumADregulation of protein localization to plasma membrane48/3918104/187237.17e-094.36e-0748
GO:0051222ColorectumADpositive regulation of protein transport106/3918303/187238.45e-095.08e-07106
GO:1904375ColorectumADregulation of protein localization to cell periphery54/3918125/187231.52e-089.00e-0754
GO:0032984ColorectumADprotein-containing complex disassembly81/3918224/187239.41e-084.65e-0681
GO:1905477ColorectumADpositive regulation of protein localization to membrane46/3918106/187231.47e-076.64e-0646
GO:0016050ColorectumADvesicle organization101/3918300/187231.65e-077.17e-06101
GO:0090316ColorectumADpositive regulation of intracellular protein transport62/3918160/187231.82e-077.79e-0662
GO:0032388ColorectumADpositive regulation of intracellular transport74/3918202/187231.83e-077.80e-0674
GO:0032386ColorectumADregulation of intracellular transport109/3918337/187235.33e-071.95e-05109
GO:0033157ColorectumADregulation of intracellular protein transport80/3918229/187235.81e-072.09e-0580
GO:0009743ColorectumADresponse to carbohydrate86/3918253/187238.43e-072.90e-0586
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05012ColorectumADParkinson disease147/2092266/84652.53e-278.48e-255.41e-25147
hsa05010ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa05016ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa05020ColorectumADPrion disease133/2092273/84652.47e-188.29e-175.29e-17133
hsa05014ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa05022ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa04144ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa05132ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa04728ColorectumADDopaminergic synapse46/2092132/84655.55e-032.48e-021.58e-0246
hsa050121ColorectumADParkinson disease147/2092266/84652.53e-278.48e-255.41e-25147
hsa050101ColorectumADAlzheimer disease174/2092384/84651.82e-199.26e-185.91e-18174
hsa050161ColorectumADHuntington disease147/2092306/84651.93e-199.26e-185.91e-18147
hsa050201ColorectumADPrion disease133/2092273/84652.47e-188.29e-175.29e-17133
hsa050141ColorectumADAmyotrophic lateral sclerosis164/2092364/84654.28e-181.27e-168.09e-17164
hsa050221ColorectumADPathways of neurodegeneration - multiple diseases201/2092476/84654.54e-181.27e-168.09e-17201
hsa041441ColorectumADEndocytosis111/2092251/84655.95e-121.42e-109.08e-11111
hsa051321ColorectumADSalmonella infection102/2092249/84657.65e-091.28e-078.17e-08102
hsa047281ColorectumADDopaminergic synapse46/2092132/84655.55e-032.48e-021.58e-0246
hsa050124ColorectumMSSParkinson disease140/1875266/84652.32e-287.79e-264.77e-26140
hsa050104ColorectumMSSAlzheimer disease169/1875384/84651.21e-221.01e-206.21e-21169
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KIF5BSNVMissense_Mutationnovelc.1720G>Tp.Val574Leup.V574LP33176protein_codingtolerated(0.53)benign(0)TCGA-A2-A04Y-01Breastbreast invasive carcinomaFemale<65I/IIChemotherapycytoxanSD
KIF5BSNVMissense_Mutationnovelc.156N>Ap.Phe52Leup.F52LP33176protein_codingtolerated(0.31)benign(0.17)TCGA-AC-A2BK-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapycytoxanCR
KIF5BSNVMissense_Mutationc.591G>Ap.Met197Ilep.M197IP33176protein_codingdeleterious(0)probably_damaging(0.948)TCGA-BH-A0EE-01Breastbreast invasive carcinomaFemale>=65I/IIChemotherapydocetaxelSD
KIF5BSNVMissense_Mutationc.16N>Ap.Glu6Lysp.E6KP33176protein_codingdeleterious(0)possibly_damaging(0.776)TCGA-BH-A0HP-01Breastbreast invasive carcinomaFemale>=65III/IVChemotherapydoxorubicinSD
KIF5BSNVMissense_Mutationnovelc.917C>Tp.Ser306Leup.S306LP33176protein_codingdeleterious(0.01)possibly_damaging(0.541)TCGA-D8-A73X-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
KIF5BSNVMissense_Mutationrs746242956c.1415N>Tp.Ala472Valp.A472VP33176protein_codingtolerated(0.23)benign(0.104)TCGA-EW-A6SB-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
KIF5BinsertionNonsense_Mutationnovelc.1179_1180insTTAGCTTAAAAAGAGGGGGAAGAp.Lys394LeufsTer3p.K394Lfs*3P33176protein_codingTCGA-AR-A0U0-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
KIF5BSNVMissense_Mutationnovelc.2104G>Ap.Glu702Lysp.E702KP33176protein_codingdeleterious(0.04)possibly_damaging(0.589)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KIF5BSNVMissense_Mutationnovelc.2870N>Cp.Gly957Alap.G957AP33176protein_codingdeleterious_low_confidence(0.01)probably_damaging(0.981)TCGA-C5-A8XH-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KIF5BSNVMissense_Mutationnovelc.1892N>Ap.Ala631Glup.A631EP33176protein_codingtolerated(0.9)benign(0.003)TCGA-C5-A8YQ-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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