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Gene: KIF2C |
Gene summary for KIF2C |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | KIF2C | Gene ID | 11004 |
| Gene name | kinesin family member 2C | |
| Gene Alias | CT139 | |
| Cytomap | 1p34.1 | |
| Gene Type | protein-coding | GO ID | GO:0000070 | UniProtAcc | B7Z6Q6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 11004 | KIF2C | LZE2T | Human | Esophagus | ESCC | 2.18e-04 | 7.78e-01 | 0.082 |
| 11004 | KIF2C | LZE22T | Human | Esophagus | ESCC | 1.57e-02 | 3.08e-01 | 0.068 |
| 11004 | KIF2C | P2T-E | Human | Esophagus | ESCC | 9.53e-09 | 3.71e-01 | 0.1177 |
| 11004 | KIF2C | P5T-E | Human | Esophagus | ESCC | 3.60e-13 | 3.65e-01 | 0.1327 |
| 11004 | KIF2C | P10T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.47e-01 | 0.116 |
| 11004 | KIF2C | P15T-E | Human | Esophagus | ESCC | 2.11e-03 | 1.81e-01 | 0.1149 |
| 11004 | KIF2C | P16T-E | Human | Esophagus | ESCC | 1.66e-02 | 6.58e-02 | 0.1153 |
| 11004 | KIF2C | P17T-E | Human | Esophagus | ESCC | 4.48e-07 | 4.69e-01 | 0.1278 |
| 11004 | KIF2C | P20T-E | Human | Esophagus | ESCC | 2.18e-03 | 1.53e-01 | 0.1124 |
| 11004 | KIF2C | P21T-E | Human | Esophagus | ESCC | 2.02e-06 | 2.47e-01 | 0.1617 |
| 11004 | KIF2C | P24T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.82e-01 | 0.1287 |
| 11004 | KIF2C | P28T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.16e-01 | 0.1149 |
| 11004 | KIF2C | P31T-E | Human | Esophagus | ESCC | 4.17e-05 | 2.23e-01 | 0.1251 |
| 11004 | KIF2C | P32T-E | Human | Esophagus | ESCC | 9.02e-11 | 3.11e-01 | 0.1666 |
| 11004 | KIF2C | P36T-E | Human | Esophagus | ESCC | 2.82e-02 | 1.18e-01 | 0.1187 |
| 11004 | KIF2C | P37T-E | Human | Esophagus | ESCC | 6.05e-08 | 2.52e-01 | 0.1371 |
| 11004 | KIF2C | P38T-E | Human | Esophagus | ESCC | 5.18e-03 | 1.45e-01 | 0.127 |
| 11004 | KIF2C | P44T-E | Human | Esophagus | ESCC | 7.53e-03 | 1.47e-01 | 0.1096 |
| 11004 | KIF2C | P52T-E | Human | Esophagus | ESCC | 9.44e-07 | 2.49e-01 | 0.1555 |
| 11004 | KIF2C | P62T-E | Human | Esophagus | ESCC | 1.20e-02 | 1.38e-01 | 0.1302 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
| GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
| GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
| GO:000007011 | Esophagus | ESCC | mitotic sister chromatid segregation | 138/8552 | 168/18723 | 1.37e-22 | 2.63e-20 | 138 |
| GO:00008194 | Esophagus | ESCC | sister chromatid segregation | 157/8552 | 202/18723 | 8.41e-21 | 1.33e-18 | 157 |
| GO:000705911 | Esophagus | ESCC | chromosome segregation | 238/8552 | 346/18723 | 1.72e-18 | 1.82e-16 | 238 |
| GO:005131011 | Esophagus | ESCC | metaphase plate congression | 58/8552 | 65/18723 | 1.81e-13 | 8.63e-12 | 58 |
| GO:000708011 | Esophagus | ESCC | mitotic metaphase plate congression | 47/8552 | 50/18723 | 3.15e-13 | 1.47e-11 | 47 |
| GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
| GO:00988133 | Esophagus | ESCC | nuclear chromosome segregation | 187/8552 | 281/18723 | 1.00e-12 | 4.36e-11 | 187 |
| GO:005130311 | Esophagus | ESCC | establishment of chromosome localization | 67/8552 | 80/18723 | 1.92e-12 | 8.09e-11 | 67 |
| GO:005000011 | Esophagus | ESCC | chromosome localization | 68/8552 | 82/18723 | 3.37e-12 | 1.32e-10 | 68 |
| GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
| GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
| GO:000716320 | Esophagus | ESCC | establishment or maintenance of cell polarity | 143/8552 | 218/18723 | 2.05e-09 | 4.65e-08 | 143 |
| GO:00519833 | Esophagus | ESCC | regulation of chromosome segregation | 67/8552 | 91/18723 | 5.42e-08 | 9.66e-07 | 67 |
| GO:00086081 | Esophagus | ESCC | attachment of spindle microtubules to kinetochore | 29/8552 | 35/18723 | 6.61e-06 | 6.75e-05 | 29 |
| GO:00513151 | Esophagus | ESCC | attachment of mitotic spindle microtubules to kinetochore | 15/8552 | 15/18723 | 7.81e-06 | 7.69e-05 | 15 |
| GO:00311094 | Esophagus | ESCC | microtubule polymerization or depolymerization | 77/8552 | 122/18723 | 7.60e-05 | 5.68e-04 | 77 |
| GO:00436245 | Esophagus | ESCC | cellular protein complex disassembly | 78/8552 | 136/18723 | 4.00e-03 | 1.62e-02 | 78 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| KIF2C | SNV | Missense_Mutation | c.1739G>C | p.Arg580Thr | p.R580T | Q99661 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
| KIF2C | SNV | Missense_Mutation | rs760237957 | c.278N>A | p.Arg93Gln | p.R93Q | Q99661 | protein_coding | deleterious(0.01) | benign(0.011) | TCGA-AR-A0U3-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
| KIF2C | SNV | Missense_Mutation | c.1270G>A | p.Asp424Asn | p.D424N | Q99661 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-C8-A12K-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| KIF2C | SNV | Missense_Mutation | novel | c.835G>C | p.Asp279His | p.D279H | Q99661 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EW-A6SB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| KIF2C | insertion | Frame_Shift_Ins | novel | c.1211_1212insGG | p.Ile404MetfsTer46 | p.I404Mfs*46 | Q99661 | protein_coding | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| KIF2C | insertion | Nonsense_Mutation | novel | c.1212_1213insCCATCCTTGAGTGGATACTGAATGAGGTATCACCCGT | p.Tyr405ProfsTer7 | p.Y405Pfs*7 | Q99661 | protein_coding | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
| KIF2C | insertion | Frame_Shift_Ins | novel | c.1313_1314insCTATGCCATGGCCTGTAAGTACTGTGTACTGCTGCTTCAG | p.Val439TyrfsTer15 | p.V439Yfs*15 | Q99661 | protein_coding | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | ||
| KIF2C | insertion | Frame_Shift_Ins | novel | c.1321_1322insCG | p.Ala442LeufsTer8 | p.A442Lfs*8 | Q99661 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| KIF2C | insertion | Nonsense_Mutation | novel | c.1323_1324insTTCCTTAGAGTGGGATCTAGATAATAAAAATA | p.Ala442PhefsTer8 | p.A442Ffs*8 | Q99661 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| KIF2C | deletion | Frame_Shift_Del | novel | c.364delA | p.Ile122SerfsTer41 | p.I122Sfs*41 | Q99661 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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