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Gene: KIAA2026 |
Gene summary for KIAA2026 |
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Gene information | Species | Human | Gene symbol | KIAA2026 | Gene ID | 158358 |
Gene name | KIAA2026 | |
Gene Alias | KIAA2026 | |
Cytomap | 9p24.1 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q5HYC2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
158358 | KIAA2026 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.98e-25 | -6.81e-01 | 0.0155 |
158358 | KIAA2026 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.18e-02 | -3.61e-01 | -0.1808 |
158358 | KIAA2026 | HTA11_2951_2000001011 | Human | Colorectum | AD | 7.33e-03 | -6.86e-01 | 0.0216 |
158358 | KIAA2026 | HTA11_3361_2000001011 | Human | Colorectum | AD | 7.62e-11 | -6.84e-01 | -0.1207 |
158358 | KIAA2026 | HTA11_83_2000001011 | Human | Colorectum | SER | 3.24e-02 | -3.24e-01 | -0.1526 |
158358 | KIAA2026 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.69e-12 | -4.54e-01 | -0.1464 |
158358 | KIAA2026 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.85e-09 | -4.59e-01 | -0.1001 |
158358 | KIAA2026 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.08e-06 | -3.85e-01 | -0.059 |
158358 | KIAA2026 | HTA11_5216_2000001011 | Human | Colorectum | SER | 7.95e-03 | -5.19e-01 | -0.1462 |
158358 | KIAA2026 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.14e-04 | -4.80e-01 | -0.0842 |
158358 | KIAA2026 | HTA11_7862_2000001011 | Human | Colorectum | AD | 2.32e-02 | -5.70e-01 | -0.0179 |
158358 | KIAA2026 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.47e-18 | -6.69e-01 | 0.096 |
158358 | KIAA2026 | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.44e-03 | -5.82e-01 | 0.0528 |
158358 | KIAA2026 | HTA11_6801_2000001011 | Human | Colorectum | SER | 2.88e-02 | -6.39e-01 | 0.0171 |
158358 | KIAA2026 | HTA11_10711_2000001011 | Human | Colorectum | AD | 2.25e-08 | -5.97e-01 | 0.0338 |
158358 | KIAA2026 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.45e-13 | -5.10e-01 | 0.0674 |
158358 | KIAA2026 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.35e-07 | -5.00e-01 | 0.0588 |
158358 | KIAA2026 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.96e-15 | -4.54e-01 | 0.294 |
158358 | KIAA2026 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.69e-09 | -4.35e-01 | 0.3859 |
158358 | KIAA2026 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.67e-08 | -6.67e-01 | 0.2585 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA2026 | SNV | Missense_Mutation | novel | c.4741N>A | p.Gln1581Lys | p.Q1581K | Q5HYC2 | protein_coding | deleterious(0) | benign(0.275) | TCGA-A2-A0SX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | PD |
KIAA2026 | SNV | Missense_Mutation | novel | c.1779N>C | p.Arg593Ser | p.R593S | Q5HYC2 | protein_coding | tolerated(0.79) | benign(0) | TCGA-A7-A3IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
KIAA2026 | SNV | Missense_Mutation | novel | c.1530N>C | p.Glu510Asp | p.E510D | Q5HYC2 | protein_coding | deleterious(0.04) | probably_damaging(0.941) | TCGA-A7-A3IZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
KIAA2026 | SNV | Missense_Mutation | novel | c.6165N>T | p.Leu2055Phe | p.L2055F | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIAA2026 | SNV | Missense_Mutation | c.3854N>A | p.Arg1285Gln | p.R1285Q | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KIAA2026 | SNV | Missense_Mutation | novel | c.2498N>A | p.Arg833Lys | p.R833K | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KIAA2026 | SNV | Missense_Mutation | novel | c.766N>C | p.Glu256Gln | p.E256Q | Q5HYC2 | protein_coding | deleterious(0.01) | possibly_damaging(0.647) | TCGA-AR-A0TZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unspecific | Doxorubicin | PD |
KIAA2026 | SNV | Missense_Mutation | novel | c.3983N>T | p.Thr1328Ile | p.T1328I | Q5HYC2 | protein_coding | deleterious(0.01) | benign(0.103) | TCGA-B6-A0WY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KIAA2026 | SNV | Missense_Mutation | novel | c.1622N>G | p.Asn541Ser | p.N541S | Q5HYC2 | protein_coding | tolerated(0.76) | benign(0) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
KIAA2026 | SNV | Missense_Mutation | novel | c.5669N>A | p.Ile1890Asn | p.I1890N | Q5HYC2 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BH-A0WA-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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